How to Use and Interpret the Results of a Platform Trial

Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID-19

(2021) Gilmar Reis et al.   JAMA Network Open

Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances

(2021) Aaron M. Orkin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

(2021) Ly-Mee Yu et al.   LANCET

An Overview of Platform Trials with a Checklist for Clinical Readers

(2020) Jay J.H. Park et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks

(2020) Natalie E. Dean et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic and External Controls in Clinical Trials – A Primer for Researchers

(2020) Kristian Thorlund et al.   Clinical Epidemiology

Including non-concurrent control patients in the analysis of platform trials: is it worth it?

(2020) Kim May Lee et al.   BMC Medical Research Methodology

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

(2020) Munyaradzi Dimairo et al.   Trials

The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

(2020) Munyaradzi Dimairo et al.   BMJ-British Medical Journal

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Simulation Practices For Adaptive Trial Designs In Drug And Device Development

(2019) C. Mayer et al.   Statistics in Biopharmaceutical Research

This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols

(2019) Francesca Schiavone et al.   Trials

Adaptive platform trials: definition, design, conduct and reporting considerations

(2019)   NATURE REVIEWS DRUG DISCOVERY

RoB 2: a revised tool for assessing risk of bias in randomised trials

(2019) Jonathan A C Sterne et al.   BMJ-British Medical Journal

Comparison of methods for control allocation in multiple arm studies using response adaptive randomization

(2019) Kert Viele et al.   Clinical Trials

Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols

(2019) Jay J. H Park et al.   Trials

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol

(2018) M R Sydes et al.   ANNALS OF ONCOLOGY

Key design considerations for adaptive clinical trials: a primer for clinicians

(2018) Kristian Thorlund et al.   BMJ-British Medical Journal

Key design considerations for adaptive clinical trials: a primer for clinicians

(2018) Kristian Thorlund et al.   BMJ-British Medical Journal

Time for Clinicians to Embrace Their Inner Bayesian?

(2018) Roger J. Lewis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bayesian Hierarchical Models

(2018) Anna E. McGlothlin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials

(2017) Melanie Quintana et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

(2017) Janet Woodcock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficiencies of platform clinical trials: A vision of the future

(2016) Benjamin R Saville et al.   Clinical Trials

Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations

(2016) Sander Greenland et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Interpretation of Clinical Trials That Stopped Early

(2016) Kert Viele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adaptive Designs for Clinical Trials

(2016) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unknown

(2016)   STATISTICS IN MEDICINE

Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer

(2016) Nicholas D. James et al.   JAMA Oncology

The Platform Trial

(2015) Scott M. Berry et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The utility of Bayesian predictive probabilities for interim monitoring of clinical trials

(2014) Benjamin R Saville et al.   Clinical Trials

More multiarm randomised trials of superiority are needed

(2014) Mahesh K B Parmar et al.   LANCET

Use of historical control data for assessing treatment effects in clinical trials

(2013) Kert Viele et al.   PHARMACEUTICAL STATISTICS

Response-adaptive designs for continuous treatment responses in phase III clinical trials: A review

(2012) Atanu Biswas et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

(2012) Matthew R Sydes et al.   Trials

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

(2009) AD Barker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS