Article
Food Science & Technology
Mrunmai Tapadia, Stuart Johnson, Ranjeet Utikar, Philip Newsholme, Rodrigo Carlessi
Summary: The gamma-conglutin peptides showed a potential insulin-mimetic action in muscle cells by activating insulin signaling pathways and also effectively inhibited DPP4 activity, indicating their potential to prolong the half-life of incretin hormones in circulation. These results support the health benefits of consuming lupin seeds and suggest a shift in the market towards lupin-based food products for human consumption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Mariusz Dabrowski
Summary: Cancer has become the leading cause of death in the European Union population under 65 in the last decade, with diabetes considered as a factor increasing cancer risk. Antidiabetic medications can affect cancer risk through various mechanisms, with some medications having beneficial effects while others may potentially be harmful. The use of inhibitors of the sodium-glucose cotransporter-2 (SGLT-2) in type 2 diabetes treatment and their association with cancer risk requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
S. Abdelgani, C. Puckett, J. Adams, C. Triplitt, R. A. DeFronzo, M. Abdul-Ghani
Summary: The study demonstrated that beta cell function plays a vital role in predicting response to glucose lowering medications in newly diagnosed T2DM patients. The C-Pep(120)/C-Pep(0) ratio is a practical tool for guiding the choice of glucose lowering agent.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cell Biology
Desh Deepak Singh, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K. Yadav
Summary: There are common molecular mechanisms and underlying pathology, such as insulin resistance and impaired synaptic plasticity, between type 2 diabetes mellitus and dementia. Analyzing risk factors is crucial for disease development and clinical management.
Review
Chemistry, Medicinal
Huei-Ping Tzeng, Shing-Hwa Liu, Meng-Tsan Chiang
Summary: Chitosan and its derivatives have shown potential in alleviating diabetic hyperglycemia through various mechanisms such as inhibiting hepatic gluconeogenesis, increasing muscle glucose uptake, and reducing insulin resistance. Clinical trials demonstrate that chitosan can increase insulin sensitivity and reduce body weight in obese patients.
Article
Geriatrics & Gerontology
Kristen DeCarlo, Amisha Wallia, Raymond H. Kang, Andrew Cooper, Manisha Cherupally, Sterling A. Harris, Cassandra Aikman, David T. Liss, Ronald T. Ackermann, Matthew J. O'Brien
Summary: Despite clinical consensus to use caution in prescribing certain antidiabetic medications among older adults in poor health, these medications remain commonly used in this population.
Review
Endocrinology & Metabolism
Ebrahim Abbasi, Iraj Khodadadi
Summary: Studies have shown that soybean and isoflavones can reduce the risk of diabetes. Genistein, an isoflavone, has been found to inhibit hepatic glucose production, increase β-cell proliferation, reduce β-cell apoptosis, and exhibit potential antioxidant and anti-diabetic effects, making it useful in managing diabetes.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Sarah I. Othman, Asma M. Alturki, Gasem Mohammad Abu-Taweel, Naif Ghazi Altoom, Ahmed A. Allam, Rehab Abdelmonem
Summary: Chitosan, with its excellent pharmacokinetic and chemical properties, is an attractive and promising carbohydrate biopolymer in biomedical applications, particularly in the treatment of diabetes mellitus. Its potential benefits lie in delivering antidiabetic drugs through nanocarriers to reduce blood glucose levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Mahmoud Elsabahy, Yue Song, Noura G. Eissa, Sarosh Khan, Mostafa A. Hamad, Karen L. Wooley
Summary: Zwitterionic polymer nanoparticles were designed to extend the pharmacological activities of insulin peptides, aiming to reduce administration frequency and improve patient compliance. These nanoparticles showed high biocompatibility and extended hypoglycemic activities of short-acting insulin and long-acting insulin glargine in rat models of diabetes, demonstrating their potential for further development in diabetes management.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Endocrinology & Metabolism
Thiago M. Batista, Nida Haider, C. Ronald Kahn
Summary: Insulin resistance plays a critical role in the pathogenesis of type 2 diabetes, with defects in glucose, lipid, and protein metabolism. Research has shown that insulin receptors not only function in classic target tissues, but also play important roles in non-classical target tissues, providing insights into the mechanisms of insulin resistance.
Article
Endocrinology & Metabolism
Vishal Musale, R. Charlotte Moffett, Bosede Owolabi, J. Michael Conlon, Peter R. Flatt, Yasser H. A. Abdel-Wahab
Summary: The study investigated the antidiabetic effects and mechanisms of action of [S4K]CPF-AM1 peptide in db/db mice, showing significant improvements in blood glucose, HbA1c levels, plasma insulin concentration, insulin sensitivity, and insulin secretion and action. Additionally, the peptide treatment also led to a reduction in abnormal biomarkers associated with liver and kidney function in the db/db mice.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
David de Paulo Farias, Fabio Fernandes de Araujo, Iramaia Angelica Neri-Numa, Glaucia Maria Pastore
Summary: The study found that phenolic compounds have the potential to play a fundamental role in managing diabetes by reducing blood glucose levels, inhibiting oxidative stress, protein glycation, and activating biochemical pathways to improve pancreatic beta-cell functions, increase insulin secretion, and improve insulin resistance. These compounds could be considered as a potential strategy in the development of pharmaceutical approaches to reduce complications resulting from the progression of this metabolic pathology.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Wei-Ren Lin, Kuan-Hung Liu, Tsai-Chieh Ling, Ming-Cheng Wang, Wei-Hung Lin
Summary: Insulin resistance is a condition where target tissues have a diminished response to insulin, resulting in impaired glucose uptake and elevated blood sugar levels. This can lead to beta cell dysfunction and ultimately the development of type 2 diabetes mellitus. Insulin resistance is also associated with cardiovascular disease and is common in patients with chronic kidney disease. The mechanisms of insulin resistance in CKD are complex and include factors such as physical inactivity, inflammation, metabolic acidosis, and vitamin D deficiency. Various anti-diabetic medications have different effects on insulin resistance. This review discusses the potential mechanisms of insulin resistance in CKD patients and the interaction of current anti-diabetic medications with insulin resistance.
WORLD JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Alexandre A. da Silva, John E. Hall, Xuemei Dai, Zhen Wang, Mateus C. Salgado, Jussara M. do Carmo
Summary: The study revealed that the CNS-mediated antidiabetic effects of Leptin involve the release of factors stimulated by Leptin that enhance glucose utilization and reduce liver gluconeogenesis.
Article
Microbiology
Biagio Pinchera, Nicola Schiano Moriello, Antonio Riccardo Buonomo, Isabella Di Filippo, Anastasia Tanzillo, Giorgio Buzzo, Riccardo Villari, Ivan Gentile
Summary: Diabetes mellitus is a common comorbidity in COVID-19 patients and is associated with a worse prognosis. However, the underlying mechanism for this negative outcome is still not completely understood. Our study aimed to investigate the potential role of antidiabetic therapy in the progression of COVID-19.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)