Article
Chemistry, Multidisciplinary
Jinzhong Hu, Zhiguo Gao, Kai Sun, Min Liu, Zining Wang, Jiaying Yu, Wanying Wei, Xiaofan He, Senlin Wang, Yaojia Li, Baiwang Sun
Summary: A redox-triggered PTX liposome system (PTX-SS-CP) based on PTX disulfide CP conjugates (PTX-SS-CP) has been developed. This system exhibits rapid release, high cellular uptake capacity, and improved anticancer efficiency under reductive conditions (GSH). It shows strong tumor targeting efficacy and growth inhibition in in vivo studies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yujin Lee, Nanhee Song, Nuri Kim, Manseok Yang, Gayoung Kwon, Hyejin Hyeon, Eunkyeong Jung, Seong-Cheol Park, Chunho Kim, Dongwon Lee
Summary: A ROS-generating polyprodrug of cinnamaldehyde (CA) has been developed, which serves as a drug carrier and synergizes with drug payloads. The polyprodrug can self-assemble with a tumor-targeting lipopeptide and encapsulate doxorubicin to exert synergistic anticancer actions.
Article
Chemistry, Multidisciplinary
Jinzhong Hu, Zhiguo Gao, Kai Sun, Min Liu, Zining Wang, Jiaying Yu, Wanying Wei, Xiaofan He, Senlin Wang, Yaojia Li, Baiwang Sun
Summary: A new PTX liposome system based on PTX disulfide CP conjugates has been studied, which exhibits rapid release, high cellular uptake capacity, and improved anticancer efficiency. In vivo studies showed significantly stronger tumor targeting efficacy and growth inhibition compared to other PTX-SS-CP groups.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Engineering, Biomedical
Sarah J. Shepherd, David Issadore, Michael J. Mitchell
Summary: Nanomedicine has advanced significantly in clinical applications, with microfluidic devices showing potential for generating reproducible nanoparticle formulations. These formulations enhance biomedical applications with controlled physical properties, pointing towards future production scale-independent formulations through parallelization and multi-step reactions.
Review
Pharmacology & Pharmacy
Seong-Bin Yang, Nipa Banik, Bomin Han, Dong-Nyeong Lee, Jooho Park
Summary: With advancements in bioinformatics, amino acid-based drug-design strategies have become increasingly important in pharmaceutics. Despite previous limitations of low selectivity and rapid degradation, peptide-based therapeutics combined with drug-delivery systems have emerged, particularly in anticancer therapy.
Article
Chemistry, Multidisciplinary
Wenjuan Jin, Zelong Chen, Senyu Yang, Yun Qu, Yuxin Pei, Zhichao Pei
Summary: A disulfide-induced supra-amphiphilic co-assembly strategy was proposed for co-delivery of hydrophobic drugs in combination therapies, enhancing anti-tumor efficiency significantly in specific tumors through targeted therapy and phototherapy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Tiantian Guo, Haiping Zhong, Xingwei Li, Jingqing Mu, Tao Liu, Na Yu, Yang Zhao, Xing-Jie Liang, Shutao Guo
Summary: In this study, we synthesized four dextran-paclitaxel (PTX) conjugates with different drug contents and used them to construct self-assembled nanoparticles. We investigated how PTX content influenced the performance and antitumor efficacy of the nanoparticles. The results showed that nanoparticles with lower PTX content exhibited faster drug release, increased tumor accumulation, and enhanced antitumor efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Yong Huang, Yi Lin, Bowen Li, Fu Zhang, Chenyue Zhan, Xin Xie, Zhuo Yao, Chongzhi Wu, Yuan Ping, Jianliang Shen
Summary: The study presents a biomimetic self-assembly nano-prodrug system for the co-delivery of gefitinib, ferrocene, and dihydroartemisinin. This system enables the combined therapy of ferroptosis and apoptosis, leading to significant inhibition of tumor growth.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
De-Chao Yang, Lin-Feng Wen, Liyang Du, Cheng-Miao Luo, Zi-Yao Lu, Jian-Yong Liu, Zhonghui Lin
Summary: In this study, a multifunctional therapeutic BAC prodrug was designed and synthesized, which connected the chemotherapeutic drug and the fluorescent photothermal agent. The prodrug showed excellent biosafety and could perform chemotherapy in hypoxic cancer cells. Additionally, it could achieve irreversible cancer cell death through oxygen-independent photothermal therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Hanhee Cho, Seong Ik Jeon, Cheol-Hee Ahn, Man Kyu Shim, Kwangmeyung Kim
Summary: Albumin has the potential to improve the delivery of anticancer drugs by acting as a natural carrier. It can enhance the circulation time of the drugs and passively target tumors through enhanced permeability and retention. However, the delivery efficiency of exogenous albumin formulations is low, which increases the risk of systemic toxicity. Prodrugs that bind endogenous albumin have been investigated as a safer and more effective drug delivery option.
Article
Biochemistry & Molecular Biology
Fanjie Meng, Feng Li, Jin-Xing Liu, Junliang Shang, Xikui Liu, Yan Li
Summary: Compared to single-drug therapy, drug combinations have great potential in cancer treatment. This study proposes a network-embedding-based prediction model, NEXGB, which integrates protein interaction network information to predict the synergistic relationship between drug combinations and cancer cell lines. Experimental results show that NEXGB outperforms current methods and improves the predictive power in discovering relationships between drugs and cancer cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Mujeeb Ur-Rehman, Franceline Reynaud, Sinda Lepetre, Sonia Abreu, Pierre Chaminade, Elias Fattal, Nicolas Tsapis
Summary: In this study, lipid-drug conjugates (LDCs) of dexamethasone (DXM) with different lipid-drug linkages were synthesized and turned into nanoscale particles. The encapsulation efficacy of LDCs was above 95%, with good stability and no recrystallization observed. Ester and carbonate LDC nanoparticles exerted anti-inflammatory activity, while the carbamate LDC nanoparticles were toxic to macrophages and discarded. The release rate of DXM from ester particles was faster than that from carbonate particles, leading to a lower exposure to DXM from carbonate LDC nanoparticles in pharmacokinetics and biodistribution studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Chongzhi Wu, Fu Zhang, Bowen Li, Zhiyao Li, Xin Xie, Yong Huang, Zhuo Yao, Yuan Chen, Yuan Ping, Weidong Pan
Summary: A new strategy for eradicating triple-negative breast cancer stem cells (TNBCSCs) is reported using a disulfide-mediated self-assembly nano-prodrug that co-delivers ferroptosis drug, differentiation-inducing agent, and chemotherapeutics for simultaneous treatment of TNBCSCs and TNBC.
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang
Summary: A new activatable polymeric nanoprobe (APN(SO)) for real-time in vivo near-infrared fluorescence imaging and urinalysis of hepatic ischemia-reperfusion injury (IRI) is reported, which can detect IRI at least 7 hours earlier than typical clinical assays in a mouse model.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Xinting Han, Lulu Ren, Yan Ma, Xiao Gong, Hangxiang Wang
Summary: In this study, a self-repairing superhydrophobic coating with good anti-corrosion and photothermal properties was fabricated by the spaying method. The coating exhibited excellent corrosion resistance and was capable of self-repairing under sunlight. This research provides a new idea for the application of superhydrophobic coatings.
Article
Chemistry, Physical
Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu
Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.
Article
Nanoscience & Nanotechnology
X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Summary: STAT3 is a key converging point of multiple oncogenic pathways and is constitutively activated in various cancer cells. Stattic, a selective inhibitor of STAT3, has shown promising potential for targeted cancer therapy and has been formulated in nanoparticles to enhance its therapeutic effects against tumor growth and metastasis.
MATERIALS TODAY NANO
(2022)
Correction
Chemistry, Multidisciplinary
Qiong Bian, Lingling Huang, Yihua Xu, Ruxuan Wang, Yueting Gu, Anran Yuan, Xiaolu Ma, Jingyi Hu, Yuefeng Rao, Donghang Xu, Hangxiang Wang, Jianqing Gao
Article
Nanoscience & Nanotechnology
Xiao Gong, Zheng Xiong, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: A facile method is reported to prepare multifunctional cotton fabrics with high flame retardancy, high electrical conductivity, superamphiphobicity, and high electromagnetic shielding. This was achieved by modifying the cotton fabric surface with phytic acid, coating with tannic acid and 3-aminopropyltriethoxysilane, and reducing the surface energy with fluorine-containing molecules. The resulting composite cotton fabric exhibited excellent properties in all these aspects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Summary: This study describes a novel therapeutic strategy that utilizes polymeric prodrug design and cell membrane cloaking to create a highly effective and low-toxicity treatment. In animal model experiments, this biomimetic therapy exhibited a higher level of tumor accumulation and effectively suppressed tumor growth and metastasis.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Xiao Gong, Qingqing Xu, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: This paper reports the synthesis of carbon nanodots that can efficiently absorb UV and high-energy blue light. These carbon nanodots can be easily synthesized in large scale and embedded in cellulose films, resulting in ultrahigh efficient UV and blue light shielding with guaranteed visible light transmission rate.
Article
Pharmacology & Pharmacy
Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song, Hangxiang Wang
Summary: This study developed an oral liposome called budsomes to deliver the anti-inflammatory drug budesonide for the treatment of inflammatory bowel disease (IBD). The budsomes showed high stability in the stomach and released active budesonide after accumulation in inflamed intestinal tissues. Compared to free budesonide treatment, budsomes exhibited higher therapeutic efficiency and induced remission of acute colitis without adverse side effects.
Article
Multidisciplinary Sciences
Jianqin Wan, Lulu Ren, Xiaoyan Li, Shasha He, Yang Fu, Peirong Xu, Fanchao Meng, Shiyun Xian, Kanyi Pu, Hangxiang Wang
Summary: A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist system is developed to induce near-infrared light-induced immunogenic cell death (ICD) in dying tumor cells and release a potent immunoadjuvant. In mouse models, this system effectively eliminates tumors, suppresses tumor recurrence and metastasis, and activates tumor-specific T cells. This study provides a simple and cost-effective approach to generate in situ cancer vaccines for the photodynamic immunotherapy of metastatic cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Summary: Immune checkpoint blockade therapies have made a significant impact on cancer treatment, but many patients do not respond to these therapies. Researchers have developed a combination chemoimmunotherapy nanosystem that includes a gemcitabine prodrug nanoparticle decorated with an anti-PD-L1 antibody and a STING agonist. This nanosystem enhances drug delivery to ICB-refractory tumors, activates CD8+ T cell responses, and transforms low-immunogenic tumors into inflamed tumors. In multiple mouse tumor models, the triple-combination nanovesicles induce a strong antitumor immune response and result in regression of large tumors and reduction in metastatic burden. These findings provide a basis for developing chemoimmunotherapeutic strategies for treating ICB-nonresponsive tumors.
Article
Multidisciplinary Sciences
Xiaona Chen, Fanchao Meng, Yiting Xu, Tongyu Li, Xiaolong Chen, Hangxiang Wang
Summary: The authors developed esterase-activatable pro-drugs based on STING agonist MSA-2 that are incorporated into liposomal vesicles for targeted intravenous administration. These pro-drugs, delivered via liposomes (SAProsomes), show enhanced pharmacokinetic properties and immune stimulatory capacity. The best candidate, SAProsome-3, effectively stimulates secretion of inflammatory cytokines and creates a tumoricidal immune landscape, leading to durable remission and decreased metastatic burden in breast cancer and melanoma mouse models.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Medicine, General & Internal
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Summary: A nanotherapeutic strategy was developed to deliver rapamycin and 7-ethyl-10-hydroxycamptothecin in a nanoparticle, which exhibited synergistic effects against hepatocellular carcinoma and alleviated drug resistance.
Article
Engineering, Biomedical
Tongyu Li, Weiwei Shi, Jie Yao, Jingyun Hu, Qiong Sun, Jing Meng, Jian Wan, Haihan Song, Hangxiang Wang
Summary: This study presents a strategy to integrate multiple structurally disparate drugs into a self-assembling nanococktail platform. In vitro and in vivo assays demonstrate that this nanococktail therapy can effectively mitigate chemoresistance and improve the therapeutic efficacy in lung cancer. The findings suggest the potential of this approach in synergistically treating chemoresistant cancers.
BIOMATERIALS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)