Article
Pharmacology & Pharmacy
Jianfei Lai, Qianyu Qian, Qinchao Ding, Li Zhou, Ai Fu, Zhongyan Du, Cui Wang, Zhenyuan Song, Songtao Li, Xiaobing Dou
Summary: Sal A treatment attenuated weight gain and lipid accumulation in obese mice by inducing UCP-1 expression and reversing HFD-induced AMPK and SIRT1 downregulation, suggesting potential therapeutic effects for obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuelei Zhao, Xuexin Li, Ye Tian, Jindi Zhao, Wensai Yu, Lifan Zhang, Wei Wei, Jie Chen
Summary: This study found that nonivamide can induce browning of porcine adipocytes, inhibit adipogenesis and promote lipolysis, as well as up-regulate thermogenesis gene markers and mitochondrial biogenesis-related genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Yuwei Zhang, Yi Chu, Xuemei Zhao, Liufeng Mao, Shiting Zhao, Shaoqiang Lin, Xiaoyan Hui, Ping Gu, Yong Xu, Kerry Loomes, Shibing Tang, Tao Nie, Donghai Wu
Summary: Rutaecarpine, a small molecule, induces adipocyte browning and regulates the AMPK signaling pathway, presenting a potential drug candidate for obesity treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Shaofeng Xiong, Shumin Yu, Kun Wang, Xiaowei Xiong, Min Xia, Guohua Zeng, Qiren Huang
Summary: In this study, the effects of AP on glycolipid metabolism, browning, and autophagy were investigated using a mouse obesity model and a preadipocyte induction model in vitro. The results showed that AP treatment alleviated body weight, glycolipid metabolic disorder, and insulin resistance through autophagy inhibition and promotion of fat-browning. These findings suggest that autophagy inhibition promotes browning of white adipocytes and highlight the potential of AP in preventing and treating obesity and associated metabolic disorders.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Yu, Jiabing Zhu, Jian Deng, Jing Shen, Fukuan Du, Xu Wu, Yu Chen, Mingxing Li, Qinglian Wen, Zhangang Xiao, Yueshui Zhao
Summary: The study demonstrates that activation of DRD1 signaling can promote lipolysis and browning of adipocytes, reducing adipocyte size and increasing the release of fatty acids, providing new strategies for obesity treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Vinu Vijayan, Fathe Singh, Manu Sudhakar, Rachita Lakra, Purna Sai Korrapati, Manikantan Syamala Kiran
Summary: This study evaluated the impact of an angiogenic modulator on the metabolism of white adipose cells and found that Apigenin has a proangiogenic effect. Apigenin promotes the conversion of white adipose cells into a brown-like phenotype and triggers the expression of Vascular endothelial growth factor A to change the metabolism of adipose cells. This study provides new insights into using angiogenesis modulation to treat obesity.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Lugen Zuo, Zhijun Geng, Xue Song, Jing Li, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Lian Wang, Guangyong Liu, Lele Zhang, Mengyu Xu, Yajing Zhao, Li Shen, Yuanyuan Ge, Rong Wu, Jianguo Hu
Summary: In this study, it was found that white adipocyte browning occurs in hypertrophic mesenteric adipose tissue (htMAT) of Crohn's disease (CD) patients and has anti-inflammatory and lipid-depleting effects. Browning can be induced in both human htMAT and primary mesenteric adipocytes from CD patients and controls, and this induction increases their anti-inflammatory and lipid-depleting activities. Inducing MAT browning can ameliorate mesenteric hypertrophy, inflammation, and colitis in mice, suggesting that it could be a potential therapeutic target for CD.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Shenzhen Gao, Baixue Lu, Rong Zhou, Weicheng Gao
Summary: Autologous fat grafting is a common surgical procedure in plastic and cosmetic surgery, but complications such as fat necrosis, calcification, and fat embolism are challenging areas of current research. Fat necrosis, a common complication after fat grafting, directly affects both surgical outcomes and survival rates. In recent years, researchers from various countries have made significant progress in understanding the mechanisms of fat necrosis through clinical and basic studies. We summarize recent research advancements on fat necrosis to provide a theoretical basis for reducing its occurrence.
Article
Food Science & Technology
Se-Jun Park, Dong-Hyun Shon, Yang-Hwan Ryu, Yong Ko
Summary: Herbal extracts from Ephedra sinica show dual effects on adipocytes, inhibiting adipogenesis in immature cells and promoting browning in mature cells.
Article
Chemistry, Medicinal
Wenyu Gou, Hua Wei, Lindsay Swaby, Erica Green, Hongjun Wang
Summary: This study revealed the critical role of SPL in the browning of visceral white adipose tissue (vWAT). SPL knockout (KO) mice exhibited higher expression of classic browning-related genes and mtDNA levels in vWAT compared to wild type (WT) mice. Furthermore, treatment with rosiglitazone induced browning in vWAT of SPL KO mice, resulting in weight loss.
Review
Medicine, Research & Experimental
Min Jia, Tongcheng Xu, Yong-Jiang Xu, Yuanfa Liu
Summary: Brown adipose tissue (BAT) and beige fat have the potential to fight obesity and chronic diseases by rapidly consuming fatty acids and dissipating energy. This review summarizes the effects of dietary fatty acids on thermogenic adipose tissue, including activation and deactivation of BAT and beige fat.
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Article
Oncology
Hongtao Zhu, Dan Liu, Ming Sui, Meiling Zhou, Beibei Wang, Qinqin Qi, Ting Wang, Guo Zhang, Feng Wan, Bin Zhang
Summary: In this study, a novel CRISPR-based myokines activation strategy was used to evaluate its therapeutic potential in obesity treatments. The activation of FGF21 and Irisin in skeletal muscles promoted the browning of adipocytes and resulted in reduced body weight and fat mass, improved glucose tolerance and insulin sensitivity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Markus Hartmann, Sofia-Iris Bibli, Daniel Tews, Xiaomin Ni, Theresa Kircher, Jan S. Kramer, Whitney Kilu, Jan Heering, Victor Hernandez-Olmos, Lilia Weizel, Gerhard K. E. Scriba, Sulaiman Krait, Stefan Knapp, Apirat Chaikuad, Daniel Merk, Ingrid Fleming, Pamela Fischer-Posovszky, Ewgenij Proschak
Summary: Metabolic syndrome is a group of cardiovascular and metabolic symptoms, and patients often require polypharmaceutical treatment. PPAR gamma agonists show potential in treating MetS but are restricted by cardiovascular adverse events. Research has shown that RB394 can improve all risk factors of MetS and exhibits exciting potential in treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
