The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome

(2021) Sebastião Freitas de Medeiros et al.   HUMAN REPRODUCTION UPDATE

Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

(2020) Chenghu Zhang et al.   CIRCULATION RESEARCH

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis

(2020) Liping Chen et al.   HEPATOLOGY

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway

(2019) Jie Wang et al.   Cells

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

(2019) Wenshan Wang et al.   Cell Metabolism

Reduced adiponectin:leptin ratio associated with inhalation exposure to vinyl chloride monomer

(2019) Ching-Chang Lee et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial–Mesenchymal Transition

(2019) Yun Deng et al.   Cancer Management and Research

Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis

(2018) Yutaka Hasegawa et al.   Cell Metabolism

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

(2018) S Becerril et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation

(2018) Petra Kotzbeck et al.   JOURNAL OF LIPID RESEARCH

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling

(2018) Heejin Jun et al.   NATURE MEDICINE

Leptin and brain–adipose crosstalks

(2018) Alexandre Caron et al.   NATURE REVIEWS NEUROSCIENCE

Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis

(2017) Lina Xu et al.   FOOD AND CHEMICAL TOXICOLOGY

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage functions in lean and obese adipose tissue

(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis

(2017) Matthew Decker et al.   NATURE CELL BIOLOGY

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

Differences in Adipose Tissue and Lean Mass Distribution in Patients with Collagen VI Related Myopathies Are Associated with Disease Severity and Physical Ability

(2017) M. A. Rodríguez et al.   Frontiers in Aging Neuroscience

Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

(2017) Emmanuel C. Patin et al.   Frontiers in Immunology

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

(2017) Liang Xu et al.   EBioMedicine

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Cannabidiol promotes browning in 3T3-L1 adipocytes

(2016) Hilal Ahmad Parray et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease

(2016) Weilin Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer

(2016) Weiqi Zheng et al.   OncoTargets and Therapy

JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice

(2015) Sally Yu Shi et al.   DIABETOLOGIA

COL6A3 Is Regulated by Leptin in Human Adipose Tissue and Reduced in Obesity

(2015) Laura J. McCulloch et al.   ENDOCRINOLOGY

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Adipocytokines and hepatic fibrosis

(2015) Neeraj K. Saxena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Discovery and Characterization of the First Genuine Avian Leptin Gene in the Rock Dove (Columba livia)

(2014) Miriam Friedman-Einat et al.   ENDOCRINOLOGY

Hypoxia Preconditioned Mesenchymal Stem Cells Prevent Cardiac Fibroblast Activation and Collagen Production via Leptin

(2014) Panpan Chen et al.   PLoS One

Direct and indirect effects of leptin on adipocyte metabolism

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibrosis and Adipose Tissue Dysfunction

(2013) Kai Sun et al.   Cell Metabolism

Peptide-based activation of alpha5 integrin for promoting osteogenesis

(2012) Olivia Fromigué et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Selective Inhibition of Hypoxia-Inducible Factor 1  Ameliorates Adipose Tissue Dysfunction

(2012) K. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function

(2008) Eran Elinav et al.   HEPATOLOGY