Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds

A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology

(2021) Jinhong Wie et al.   NATURE

Parkinson’s Disease-Related Genes and Lipid Alteration

(2021) Milena Fais et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

(2021) Noémie Cresto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model

(2021) Jing Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rare Variants in Specific Lysosomal Genes Are Associated with Parkinson's Disease

(2020) Franziska Hopfner et al.   MOVEMENT DISORDERS

Direct trafficking pathways from the Golgi apparatus to the plasma membrane

(2020) Danièle Stalder et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glucocerebrosidase Defects as a Major Risk Factor for Parkinson’s Disease

(2020) Micol Avenali et al.   Frontiers in Aging Neuroscience

Structural basis for ion selectivity in TMEM175 K+ channels

(2020) Janine D Brunner et al.   eLife

Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

(2020) SeCheol Oh et al.   eLife

“LRRK2: Autophagy and Lysosomal Activity”

(2020) Marta Madureira et al.   Frontiers in Neuroscience

Potassium channels and their emerging role in parkinson's disease

(2020) Linlin Zhang et al.   BRAIN RESEARCH BULLETIN

Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease

(2020) Shani Blumenreich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KCND3-Related Neurological Disorders: From Old to Emerging Clinical Phenotypes

(2020) Luca Pollini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Predictors of Conversion to α-Synucleinopathy Diseases in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

(2020) Guanyu Ye et al.   Journal of Parkinsons Disease

TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion

(2020) Mengling Zhang et al.   Molecular Brain

Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms

(2020) Norelle C. Wildburger et al.   Frontiers in Cell and Developmental Biology

Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

(2019) Cornelis Blauwendraat et al.   MOVEMENT DISORDERS

Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease

(2019) Sarah Jinn et al.   HUMAN MOLECULAR GENETICS

GBA1-associated parkinsonism

(2019) Emory Ryan et al.   CURRENT OPINION IN NEUROLOGY

Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies

(2019) Lynne Krohn et al.   ANNALS OF NEUROLOGY

Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics

(2019) Konstantin Senkevich et al.   PARKINSONISM & RELATED DISORDERS

Lysosomal Dysfunction at the Centre of Parkinson’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis

(2019) Rebecca L. Wallings et al.   TRENDS IN NEUROSCIENCES

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

(2019) Daniel Ysselstein et al.   Nature Communications

Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration

(2018) Ru-Yi Chao et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

(2017) Changkeun Lee et al.   NATURE

Effect of lysosomotropic molecules on cellular homeostasis

(2017) Omer F. Kuzu et al.   PHARMACOLOGICAL RESEARCH

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

(2017) Sarah Jinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

(2017) Andrea L. Marat et al.   SCIENCE

The Hyperpolarization-Activated Current Determines Synaptic Excitability, Calcium Activity and Specific Viability of Substantia Nigra Dopaminergic Neurons

(2017) Carmen Carbone et al.   Frontiers in Cellular Neuroscience

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Covalent-Allosteric Kinase Inhibitors

(2015) Jörn Weisner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

Dynasore - not just a dynamin inhibitor

(2015) Giulio Preta et al.   Cell Communication and Signaling

Up-Regulation of Voltage Gated K+ Channels Kv1.3 and Kv1.5 by Protein Kinase PKB/Akt

(2015) Jamshed Warsi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Impact of Parkinson's disease risk loci on age at onset

(2015) Christina M. Lill et al.   MOVEMENT DISORDERS

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors

(2013) R. J. Park et al.   JOURNAL OF CELL SCIENCE

Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

(2013) Adam McCluskey et al.   TRAFFIC

Up-Regulation of the Inwardly Rectifying K+ Channel Kir2.1 (KCNJ2) by Protein Kinase B (PKB/Akt) and PIKfyve

(2012) Carlos Munoz et al.   JOURNAL OF MEMBRANE BIOLOGY

PI3-kinase/Akt Pathway-Regulated Membrane Insertion of Acid-Sensing Ion Channel 1a Underlies BDNF-Induced Pain Hypersensitivity

(2012) B. Duan et al.   JOURNAL OF NEUROSCIENCE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulum

(2009) Marie-Paule Muriel et al.   JOURNAL OF NEUROCHEMISTRY

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

(2008) Nathan Pankratz et al.   HUMAN GENETICS