Transcriptional Control of Trpm6 by the Nuclear Receptor FXR

Genetic and drug-induced hypomagnesemia: different cause, same mechanism

(2021) Willem Bosman et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Artificial‐intelligence‐driven discovery of prognostic biomarker for sarcopenia

(2021) Heewon Chung et al.   Journal of Cachexia Sarcopenia and Muscle

Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study

(2021) Mary E. Rinella et al.   JOURNAL OF HEPATOLOGY

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

(2020) Katrin Panzitt et al.   JOURNAL OF HEPATOLOGY

The Association between Excess Body Mass and Disturbances in Somatic Mineral Levels

(2020) Weronika Banach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

(2020) Man Liu et al.   Antioxidants

Cyanidin Increases the Expression of Mg2+ Transport Carriers Mediated by the Activation of PPARα in Colonic Epithelial MCE301 Cells

(2019) Yui Takashina et al.   Nutrients

TRPM7, Magnesium, and Signaling

(2019) Zhi-Guo Zou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Update on FXR Biology: Promising Therapeutic Target?

(2018) Chang Han   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

(2016) Natalia Gomez-Ospina et al.   Nature Communications

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

(2016) Vladimir Chubanov et al.   eLife

Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?

(2015) Lisanne M.M. Gommers et al.   DIABETES

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

The TRPM6 Kinase Domain Determines the Mg·ATP Sensitivity of TRPM7/M6 Heteromeric Ion Channels

(2014) Zheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

(2013) B. Chaigne-Delalande et al.   SCIENCE

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

(2012) Jeroen H. F. de Baaij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

(2012) A. V. Nair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human gene SLC41A1 encodes for the Na+/Mg2+ exchanger

(2011) Martin Kolisek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Farnesoid X receptor represses hepatic human APOA gene expression

(2011) Indumathi Chennamsetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

(2011) Feng-Yen Li et al.   NATURE

Newly Developed Mg2+–Selective Fluorescent Probe Enables Visualization of Mg2+ Dynamics in Mitochondria

(2011) Yutaka Shindo et al.   PLoS One

Transient Receptor Potential Melastatin 6 Knockout Mice Are Lethal whereas Heterozygous Deletion Results in Mild Hypomagnesemia

(2010) Titia E. Woudenberg-Vrenken et al.   NEPHRON PHYSIOLOGY

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

(2009) Alexandra Milona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Mice defective in Trpm6 show embryonic mortality and neural tube defects

(2009) R. Y. Walder et al.   HUMAN MOLECULAR GENETICS

Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis

(2008) S. Modica et al.   CANCER RESEARCH

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

SLC41A1 Is a Novel Mammalian Mg2+Carrier

(2008) Martin Kolisek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGF Increases TRPM6 Activity and Surface Expression

(2008) S. Thebault et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY