Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

What coronavirus 3C‐like protease tells us: From structure, substrate selectivity, to inhibitor design

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Considerations for the Discovery and Development of 3-Chymotrypsin-Like Cysteine Protease Inhibitors Targeting SARS-CoV-2 Infection

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MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**

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Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

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Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2

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Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

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MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway

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Discovery of M Protease inhibitors encoded by SARS-CoV-2

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MG-132 attenuates cardiac deterioration of viral myocarditis via AMPK pathway

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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

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Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

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Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

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Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

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Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

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Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

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OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

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Status of the crystallography beamlines at Elettra

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Why is Tanimoto index an appropriate choice for fingerprint-based similarity calculations?

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

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Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific

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Docking Covalent Inhibitors: A Parameter Free Approach To Pose Prediction and Scoring

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How good are my data and what is the resolution?

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MG132, a proteasome inhibitor, induces apoptosis in tumor cells

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Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain

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Overview of theCCP4 suite and current developments

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Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

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XDS

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Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

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Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors

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Dipeptidyl nitrile inhibitors of Cathepsin L

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Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus

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Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues

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Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

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