TNAP: A New Multitask Enzyme in Energy Metabolism

Tissue Nonspecific Alkaline Phosphatase Function in Bone and Muscle Progenitor Cells: Control of Mitochondrial Respiration and ATP Production

(2021) Zhi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism

(2021) Stephanie Graser et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Creatine kinase B controls futile creatine cycling in thermogenic fat

(2021) Janane F. Rahbani et al.   NATURE

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine

(2021) Yizhi Sun et al.   NATURE

Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels

(2020) Cheng Jun Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD)

(2020) Anika Nier et al.   Nutrients

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes

(2020) Kenji Ikeda et al.   Frontiers in Endocrinology

TNAP as a therapeutic target for cardiovascular calcification – a discussion of its pleiotropic functions in the body

(2020) Goettsch Claudia et al.   CARDIOVASCULAR RESEARCH

Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet

(2020) Reyes Gámez-Belmonte et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

(2020) Marlies Schippers et al.   Cells

Cholangiocyte pathobiology

(2019) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases

(2019) Shi-Hui Law et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Choline transport for phospholipid synthesis: An emerging role of choline transporter-like protein 1

(2019) Vera Hedtke et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD)

(2019) Robin C. Su et al.   PLoS One

Intestinal alkaline phosphatase ameliorates experimental colitis via toll-like receptor 4-dependent pathway

(2018) Sung Wook Hwang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

(2018) Jan F. C. Glatz et al.   JOURNAL OF LIPID RESEARCH

Loss of intestinal alkaline phosphatase leads to distinct chronic changes in bone phenotype

(2018) Florian Kuehn et al.   JOURNAL OF SURGICAL RESEARCH

The Common and Distinct Features of Brown and Beige Adipocytes

(2018) Kenji Ikeda et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genetic engineering a large animal model of human hypophosphatasia in sheep

(2018) Diarra K. Williams et al.   Scientific Reports

The role of alkaline phosphatase in intracellular lipid accumulation in the human hepatocarcinoma cell line, HepG2

(2017) George M Chirambo et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Specific knock-down of tissue non-specific alkaline phosphatase mRNA levels inhibits intracellular lipid accumulation in 3T3-L1 and HepG2 cells

(2017) George Chirambo et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Recurrent infection progressively disables host protection against intestinal inflammation

(2017) Won Ho Yang et al.   SCIENCE

Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis

(2017) Matthew Pettengill et al.   PLoS One

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypophosphatasia — aetiology, nosology, pathogenesis, diagnosis and treatment

(2016) Michael P. Whyte   Nature Reviews Endocrinology

Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells

(2016) David Estève et al.   Stem Cells International

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

(2016) Junko Morita et al.   Scientific Reports

Tissue alkaline phosphatase is involved in lipid metabolism and gene expression and secretion of adipokines in adipocytes

(2015) Claudia Hernández-Mosqueira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Liver alkaline phosphatase: A missing link between choleresis and biliary inflammation

(2015) Raoul Poupon   HEPATOLOGY

Human White and Brite Adipogenesis is Supported by MSCA1 and is Impaired by Immune Cells

(2015) David Estève et al.   STEM CELLS

Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study

(2014) Willem J. Lammers et al.   GASTROENTEROLOGY

Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

(2014) Tina Kiffer-Moreira et al.   PLoS One

Alkaline Phosphatase, Serum Phosphate, and Incident Cardiovascular Disease and Total Mortality in Older Men

(2013) Sasiwarang Goya Wannamethee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Isozyme profile and tissue-origin of alkaline phosphatases in mouse serum

(2013) Cecilia Halling Linder et al.   BONE

Acute intake of a high-fructose diet alters the balance of adipokine concentrations and induces neutrophil influx in the liver

(2013) Débora Fernandes Rodrigues et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High-fat meal induced postprandial inflammation

(2013) Mohammed Herieka et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal alkaline phosphatase prevents metabolic syndrome in mice

(2013) K. Kaliannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Associations of Serum Skeletal Alkaline Phosphatase with Elevated C-Reactive Protein and Mortality

(2012) R. Filipowicz et al.   Clinical Journal of the American Society of Nephrology

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia

(2012) Michael P. Whyte et al.   NEW ENGLAND JOURNAL OF MEDICINE

Associations of Serum Alkaline Phosphatase with Metabolic Syndrome and Mortality

(2011) Vidya Raj Krishnamurthy et al.   AMERICAN JOURNAL OF MEDICINE

Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet

(2011) Matthew Lynes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Physiological role of alkaline phosphatase explored in hypophosphatasia

(2010) Michael P. Whyte   Annals of the New York Academy of Sciences

Serum Alkaline Phosphatase and Phosphate and Risk of Mortality and Hospitalization

(2010) M. Abramowitz et al.   Clinical Journal of the American Society of Nephrology

The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

(2010) Ulrich Beuers et al.   HEPATOLOGY

Tissue-nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation

(2010) Rocío López-Posadas et al.   INFLAMMATORY BOWEL DISEASES

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet

(2010) Matthew D. Lynes et al.   LIFE SCIENCES

Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms

(2009) Cecilia Halling Linder et al.   BONE

Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality

(2009) Marcello Tonelli et al.   CIRCULATION

Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

(2009) Misa Mizumori et al.   JOURNAL OF PHYSIOLOGY-LONDON

The gut–liver-axis: Endotoxemia, inflammation, insulin resistance and NASH

(2008) Jürgen Siebler et al.   JOURNAL OF HEPATOLOGY

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH

Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl−transport in biliary epithelial cells through a PKCζ-dependent pathway

(2008) Kangmee Woo et al.   JOURNAL OF PHYSIOLOGY-LONDON