Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease

(2021) Chun Chen et al.   EMBO JOURNAL

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

(2020) Ada Ndoja et al.   CELL

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

(2020) Chun Chen et al.   Science Advances

A close look at pentose metabolism of gut bacteria

(2020) Mirko Basen et al.   FEBS Journal

Delta-secretase triggers Alzheimer’s disease pathologies in wild-type hAPP/hMAPT double transgenic mice

(2020) Zhourui Wu et al.   Cell Death & Disease

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in islet β-cells

(2019) Abass M. Conteh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

(2019) Ping Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Dopamine and Dopamine Receptors in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

(2019) Xiongfeng Pan et al.   Frontiers in Aging Neuroscience

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

(2018) C. Bäuerl et al.   LETTERS IN APPLIED MICROBIOLOGY

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

(2018) Zhi-Hao Wang et al.   Nature Communications

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

(2018) Hualong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia

(2017) Simona Adesso et al.   Frontiers in Pharmacology

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

(2016) Audrey Rivière et al.   Frontiers in Microbiology

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

(2014) Yang Yu et al.   JOURNAL OF NEURAL TRANSMISSION

CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development

(2014) Yiting Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Altered arginine metabolism in Alzheimer's disease brains

(2014) Ping Liu et al.   NEUROBIOLOGY OF AGING

CCAAT-Enhancer Binding Protein-β Expression and Elevation in Alzheimer’s Disease and Microglial Cell Cultures

(2014) Ron Strohmeyer et al.   PLoS One

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease

(2013) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

CCAAT/Enhancer binding protein β regulates prostaglandin E synthase expression and prostaglandin E2production in activated microglial cells

(2013) Marco Straccia et al.   GLIA

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Metabolic profiling of Alzheimer's disease brains

(2013) Koichi Inoue et al.   Scientific Reports

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β

(2011) Marco Straccia et al.   Journal of Neuroinflammation

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight

(2011) Zareen Amtul et al.   NEUROBIOLOGY OF AGING

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase A2 and arachidonic acid in Alzheimer's disease

(2010) Rene O. Sanchez-Mejia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

(2010) Y Ikeda-Matsuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

(2010) Reza M. Salek et al.   NEUROCHEMISTRY INTERNATIONAL

Insulin Regulates TRB3 and Other Stress-Responsive Gene Expression through Induction of C/EBPβ

(2009) Keyong Du et al.   MOLECULAR ENDOCRINOLOGY

Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ-dependent pathway

(2008) Zachary R. Healy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cyclooxygenase-2 in Synaptic Signaling

(2008) Hongwei Yang et al.   CURRENT PHARMACEUTICAL DESIGN

CCAAT/enhancer binding protein   deficiency provides cerebral protection following excitotoxic injury

(2008) M. Cortes-Canteli et al.   JOURNAL OF CELL SCIENCE

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

Differential processing and secretion of Aβ peptides and sAPPα in human platelets is regulated by thrombin and prostaglandine 2

(2008) A. Smirnov et al.   NEUROBIOLOGY OF AGING

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL