Article
Biochemistry & Molecular Biology
Laura S. Garschagen, Thomas Franke, Uwe Deppenmeier
Summary: This study reveals the importance of microbial degradation of pentoses in the human gut, identifies a novel pathway for pentose metabolism, and demonstrates the widespread distribution of this pathway in important gut bacteria.
Article
Chemistry, Applied
Jia-Jia Wen, Ming-Zhi Li, Jie-Lun Hu, Jiang Wang, Zhi-Qiang Wang, Chun-Hua Chen, Jing-Rui Yang, Xiao-Jun Huang, Ming-Yong Xie, Shao-Ping Nie
Summary: This study investigated the effects of different bioactive dietary fibers on obesity using a rat model. Ten types of fibers were evaluated and it was found that beta-glucan, arabinoxylan, xanthan gum, guar gum, apple pectin, carrageenan, inulin, and xylan were effective in reducing body weight and dyslipidemia. The fibers also improved biomarkers related to obesity and promoted the growth of beneficial bacteria in the gut. These findings suggest that dietary fiber can have a significant impact on obesity and gut microbiota.
FOOD HYDROCOLLOIDS
(2023)
Article
Ecology
Hongbin Liu, Chen Liao, Lu Wu, Jinhui Tang, Junyu Chen, Chaobi Lei, Linggang Zheng, Chenhong Zhang, Yang-Yu Liu, Joao Xavier, Lei Dai
Summary: Dietary fibers have varying effects on the gut microbiome depending on individual differences. This study observed the long-term dynamics of the gut microbiome and short-chain fatty acids in mice with different baseline microbiomes when fed with fermentable fiber inulin and resistant starch. The researchers found that the response to inulin was rapid and dependent on the baseline microbiome composition. They also developed an ecology model to explain the dynamics of the microbiome during fiber intake. The study highlights the importance of ecological modeling in understanding the microbiome's response to dietary changes.
Article
Biochemical Research Methods
LeNaiya Kydd, Priyanka Shiveshwarkar, Justyn Jaworski
Summary: Introducing metabolic pathways to the gut is important for regulating the biochemical components absorbed by the host. Different gut bacteria can lead to distinct health outcomes, and engineering bacteria to produce enzymes can achieve artificial metabolism of isoflavones.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chang Liu, Xingming Li, Jiayi Li, Fangwei Yang, Yahui Guo, Weirong Yao, He Qian, Yuliang Cheng
Summary: This study explored the regulation and interaction of torularhodin on gut microbiota and metabolites using bioinformatics methods. The results showed that torularhodin inhibited the growth of pathogenic bacteria and promoted the growth of beneficial bacteria, thereby affecting the composition and function of the gut microbiota. Additionally, torularhodin regulated the activity of key enzymes in specific pathways, resulting in changes in metabolites. These findings provide a theoretical basis for optimizing the regulation of gut microecology by a torularhodin-rich diet.
Editorial Material
Multidisciplinary Sciences
Patricia M. Nunes, Dimitrios Anastasiou
Summary: Feeding mice high-fructose corn syrup has been found to increase gut surface area, enhancing absorption of dietary nutrients and resulting in weight gain.
Review
Food Science & Technology
Mostafa H. Baky, Mohamed Salah, Nada Ezzelarab, Ping Shao, Mostafa S. Elshahed, Mohamed A. Farag
Summary: This review provides a comprehensive overview of the beneficial effects of dietary fibers on human gut health, including their impact on gut microbiota, immune function, and health-related functionalities. Various types of dietary fibers, such as cellulose, hemicellulose, resistant starch, and lignin, were found to have positive effects on human health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Microbiology
Ceylan Tanes, Kyle Bittinger, Yuan Gao, Elliot S. Friedman, Lisa Nessel, Unmesha Roy Paladhi, Lillian Chau, Erika Panfen, Michael A. Fischbach, Jonathan Braun, Ramnik J. Xavier, Clary B. Clish, Hongzhe Li, Frederic D. Bushman, James D. Lewis, Gary D. Wu
Summary: The study found that omnivore and vegan diets altered fecal amino acid levels, while a synthetic enteral nutrition lacking fiber did not have this effect. The impact on the plasma metabolome was modest, but the diets influenced broad classes of metabolites that may modify health by affecting the human microbiome.
CELL HOST & MICROBE
(2021)
Review
Nutrition & Dietetics
Peter Cronin, Susan A. Joyce, Paul W. O'Toole, Eibhlis M. O'Connor
Summary: Dietary fiber is crucial for nutrition and health, but modern dietary practices have led to a decrease in fiber consumption, potentially contributing to the rise of gut diseases. Changes in gut microbiota composition and function due to different types of dietary fiber could alter glucose and lipid metabolism.
Review
Gastroenterology & Hepatology
Maria Esteban-Torres, Lorena Ruiz, Valerio Rossini, Ken Nally, Douwe van Sinderen
Summary: The human gut microbiota plays a crucial role in host metabolism and physiology, impacting host health in various ways. This complex microbial community has developed metabolic strategies to survive and thrive in the gut environment. Glycogen accumulation, specifically in gut commensals, has been associated with important physiological functions, and understanding its role can provide insights into the composition and functionality of the gut microbiota.
Article
Agriculture, Multidisciplinary
Carlos E. Iglesias-Aguirre, Rocio Garcia-Villalba, David Beltran, Maria Dolores Frutos-Lison, Juan C. Espin, Francisco A. Tomas-Barberan, Maria V. Selma
Summary: We discovered a new bacterium in the feces of a healthy woman that can produce urolithins A and B as well as intermediate metabolites. Additionally, we developed co-culture systems that reproduced the production of urolithins upon fermentation of UM-A and UM-B. This finding demonstrates the potential of these urolithin-producing bacteria for use as probiotics and in the production of bioactive urolithins for various applications.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Francesca De Filippis, Alessia Esposito, Danilo Ercolini
Summary: Currently available probiotics are limited in microbial species, but recent research suggests that the gut microbiome holds potential for beneficial microbes. Researchers are focusing on identifying and testing new gut-origin microbial strains for the development of next-generation probiotics. While some of these strains show promise for preventing and treating chronic diseases, human studies are lacking and regulatory approval is rare. Furthermore, challenges remain in cultivation and storage methods for oxygen-sensitive bacteria before wide market application.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Alba Tamargo, Natalia Molinero, Julian J. Reinosa, Victor Alcolea-Rodriguez, Raquel Portela, Miguel A. Banares, Jose F. Fernandez, M. Victoria Moreno-Arribas
Summary: Microplastics are a recognized global problem due to their presence in natural environments and the food chain. This study found that microplastics not only have an impact on human microbiota, but also undergo biotransformation in the gastrointestinal tract. The researchers observed that microplastics alter the composition of the human colonic microbial community, and hypothesized that some members of the microbiota adhere to the surface of microplastics, promoting the formation of biofilms. Considering the increasing exposure to microplastics in consumer products, it is important to investigate the effects of plastics on gut microbiome functionality and their potential degradation by intestinal bacteria.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Carmen Tatiana Kalinowski, Monica B. Betancor, Silvia Torrecillas, Matthew Sprague, Laurence Larroquet, Vincent Veron, Stephane Panserat, Maria Soledad Izquierdo, Sadasivam J. Kaushik, Stephanie Fontagne-Dicharry
Summary: This study investigated the influence of dietary astaxanthin (AX) on glucose and lipid metabolism in rainbow trout liver. The results showed that dietary AX had a significant impact on neutral and polar lipids in the liver, hepatocyte size, cytoplasm vacuolization, and gene expression related to TAG turnover, beta-oxidation, PL and cholesterol synthesis. Overall, dietary AX modulates the oxidative phase of the pentose phosphate pathway and the last step of glycolysis, affecting various aspects of lipid metabolism in rainbow trout liver.
Review
Food Science & Technology
Ravindra Pal Singh, Raja Bhaiyya, Kiran Khandare, Jagan Mohan Rao Tingirikari
Summary: Recent advances suggest that macroalgal derived glycans have great potential in maintaining gut microbiome and immune system. Human gut bacteria can utilize macroalgal glycans to produce oligosaccharides, which interact with immune cell receptors and are available for microbial fermentation, playing important roles in balancing gut homeostasis. However, further research is needed to understand the molecular interactions between glycans and bacteria/cells.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Israel M. Scott, Gabe M. Rubinstein, Gina L. Lipscomb, Mirko Basen, Gerrit J. Schut, Amanda M. Rhaesa, W. Andrew Lancaster, Farris L. Poole, Robert M. Kelly, Michael W. W. Adams
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Mirko Basen, Volker Mueller
Article
Biotechnology & Applied Microbiology
Diep M. N. Nguyen, Gina L. Lipscomb, Gerrit J. Schut, Brian J. Vaccaro, Mirko Basen, Robert M. Kelly, Michael W. W. Adams
METABOLIC ENGINEERING
(2016)
Article
Biotechnology & Applied Microbiology
Lisa Hitschler, Michelle Kuntz, Felix Langschied, Mirko Basen
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2018)
Article
Agricultural Engineering
Mirko Basen, Amanda M. Rhaesa, Irina Kataeva, Cameron J. Prybol, Israel M. Scott, Farris L. Poole, Michael W. W. Adams
BIORESOURCE TECHNOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Irina Kataeva, Marcus B. Foston, Sung-Jae Yang, Sivakumar Pattathil, Ajaya K. Biswal, Farris L. Poole, Mirko Basen, Amanda M. Rhaesa, Tina P. Thomas, Parastoo Azadi, Victor Olman, Trina D. Saffold, Kyle E. Mohler, Derrick L. Lewis, Crissa Doeppke, Yining Zeng, Timothy J. Tschaplinski, William S. York, Mark Davis, Debra Mohnen, Ying Xu, Art J. Ragauskas, Shi-You Ding, Robert M. Kelly, Michael G. Hahn, Michael W. W. Adams
ENERGY & ENVIRONMENTAL SCIENCE
(2013)
Article
Multidisciplinary Sciences
Mirko Basen, Gerrit J. Schut, Diep M. Nguyen, Gina L. Lipscomb, Robert A. Benn, Cameron J. Prybol, Brian J. Vaccaro, Farris L. Poole, Robert M. Kelly, Michael W. W. Adams
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Energy & Fuels
Matthew Keller, Andrew Loder, Mirko Basen, Javier Izquierdo, Robert M. Kelly, Michael W. W. Adams
Article
Microbiology
Jimyung Moon, Laura Henke, Nadine Merz, Mirko Basen
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Laura Sofie Nissen, Mirko Basen
JOURNAL OF BIOTECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Alexander Katsyv, Marie Charlotte Schoelmerich, Mirko Basen, Volker Mueller
Summary: The researchers successfully isolated PFOR enzyme from Thermoanaerobacter kivui cells grown on glucose and identified the encoding gene as pfor1. This enzyme, using pyruvate as electron donor, can be used as an auxiliary enzyme in enzymatic assays, providing the ability to supply reduced Fd.
Article
Biotechnology & Applied Microbiology
Lisa Hitschler, Laura Sofie Nissen, Michelle Kuntz, Mirko Basen
Summary: By studying enzymes in Thermoanaerobacter, it was found that AdhE and AdhB play important roles in alcohol production from sugar and reduction of organic acids, while the functions of AdhA-type enzymes are less clear. Future research is needed to elucidate the role of aldehyde:ferredoxin oxidoreductase in bio-alcohol formation.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Ecology
Benjamin Zeldes, Anja Poehlein, Surbhi Jain, Christoph Baum, Rolf Daniel, Volker Mueller, Mirko Basen
Summary: DNA uptake is a common mechanism in microorganisms for rapid adaptation to new environments. This study found that a thermophilic bacterium, Thermoanaerobacter kivui, adapted to high concentrations of carbon monoxide through a horizontal gene transfer event with another thermophile, Thermoanaerobacter sp. strain X514, within the laboratory. This transfer also led to the deletion of a native operon for thiamine biosynthesis, explaining why the adapted strain required added vitamins for growth.
ISME COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Mirko Basen, Irina Geiger, Laura Henke, Volker Mueller
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
