Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury

Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord

(2020) Tasuku Nishihara et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

(2020) Jason R. Plemel et al.   Science Advances

Qualitative sex differences in pain processing: emerging evidence of a biased literature

(2020) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer

(2020) Shannon E. Gilchrist et al.   Frontiers in Cellular Neuroscience

The phagocytic state of brain myeloid cells after ischemia revealed by superresolution structured illumination microscopy

(2019) Stefano Fumagalli et al.   Journal of Neuroinflammation

Brain Microglial Activation in Chronic Pain-Associated Affective Disorder

(2019) Ellane Eda Barcelon et al.   Frontiers in Neuroscience

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

(2019) Nicholas N. Jarjour et al.   NATURE IMMUNOLOGY

Peripheral Nerve Injury Triggers Neuroinflammation in the Medial Prefrontal Cortex and Ventral Hippocampus in a Subgroup of Rats with Coincident Affective Behavioural Changes

(2019) Nathan T. Fiore et al.   NEUROSCIENCE

Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination

(2019) Li-Wen Chu et al.   PHYTOMEDICINE

Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice

(2018) Lang-Yue Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Glial-cytokine-neuronal Adaptations in the Ventral Hippocampus of Rats with Affective Behavioral Changes Following Peripheral Nerve Injury

(2018) Nathan T. Fiore et al.   NEUROSCIENCE

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy

(2017) Justin G. Lees et al.   EUROPEAN JOURNAL OF CANCER

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine

(2017) Hillary H. Doyle et al.   JOURNAL OF NEUROSCIENCE

Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy

(2017) Preet G. S. Makker et al.   PLoS One

Sex differences in peripheral not central immune responses to pain-inducing injury

(2017) Douglas M. Lopes et al.   Scientific Reports

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

(2016) Nan Gu et al.   BRAIN BEHAVIOR AND IMMUNITY

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

(2016) Yong Liu et al.   JOURNAL OF NEUROSCIENCE

Topography of microglial activation in sensory- and affect-related brain regions in chronic pain

(2016) Anna M.W. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury

(2016) Heejin Jeong et al.   PAIN

Neuropathic pain

(2016) Nanna B. Finnerup et al.   PAIN

eIF2α phosphorylation controls thermal nociception

(2016) Arkady Khoutorsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain

(2016) Franziska Denk et al.   Cell Reports

Galectin-3 Inhibition Is Associated with Neuropathic Pain Attenuation after Peripheral Nerve Injury

(2016) Zhicong Ma et al.   PLoS One

Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes

(2015) Lude Franke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Role for microglia in sex differences after ischemic stroke: importance of M2

(2015) Sheetal Bodhankar et al.   METABOLIC BRAIN DISEASE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Gait analysis and the cumulative gait index (CGI): Translational tools to assess impairments exhibited by rats with olivocerebellar ataxia

(2014) C.S. Lambert et al.   BEHAVIOURAL BRAIN RESEARCH

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Involvement of the Chemokine CCL3 and the Purinoceptor P2×7 in the Spinal Cord in Paclitaxel-Induced Mechanical Allodynia

(2014) Ryutaro Ochi-Ishi et al.   Molecular Pain

Role of Spinal P2Y6 and P2Y11 Receptors in Neuropathic Pain in Rats: Possible Involvement of Glial Cells

(2014) Paulino Barragán-Iglesias et al.   Molecular Pain

Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

(2014) C.R. Robinson et al.   NEUROSCIENCE

Chemotherapy-induced peripheral neuropathy and its association with quality of life: a systematic review

(2014) Floortje Mols et al.   SUPPORTIVE CARE IN CANCER

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Morphologic Features and Glial Activation in Rat Oxaliplatin-Dependent Neuropathic Pain

(2013) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF PAIN

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Cognitive and emotional control of pain and its disruption in chronic pain

(2013) M. Catherine Bushnell et al.   NATURE REVIEWS NEUROSCIENCE

The ε4 Allele of the APOE Gene Is Associated With More Severe Peripheral Neuropathy in Type 2 Diabetic Patients

(2012) C. Monastiriotis et al.   ANGIOLOGY

State of the art paper APOE gene polymorphisms and diabetic peripheral neuropathy

(2012) Christodoulos Monastiriotis et al.   Archives of Medical Science

The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy

(2012) J. Blackbeard et al.   EUROPEAN JOURNAL OF PAIN

Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain

(2012) L. Sun et al.   JOURNAL OF NEUROSCIENCE

Evidence That Spinal Astrocytes but Not Microglia Contribute to the Pathogenesis of Paclitaxel-Induced Painful Neuropathy

(2012) Haijun Zhang et al.   JOURNAL OF PAIN

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice

(2011) Hee-Young Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination

(2011) Jianmei Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries

(2011) F.Y. Zheng et al.   NEUROSCIENCE

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

(2010) Amelia A. Staniland et al.   JOURNAL OF NEUROCHEMISTRY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve

(2010) D. Mor et al.   NEUROSCIENCE

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain

(2007) Stefania Echeverry et al.   PAIN