c-Src facilitates tumorigenesis by phosphorylating and activating G6PD

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

(2020) Huanhuan Ma et al.   Cell Reports

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

(2018) Eunae Sandra Cho et al.   Biomolecules & Therapeutics

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

(2017) H-Q Ju et al.   ONCOGENE

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

(2017) Jia Zhang et al.   Nature Communications

Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells

(2016) Zishui Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

(2016) Terytty Yang Li et al.   MOLECULAR CELL

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance

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6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

(2015) Ruiting Lin et al.   NATURE CELL BIOLOGY

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

(2015) Xiongjian Rao et al.   Nature Communications

Glucose-6-phosphate Dehydrogenase: a Biomarker and Potential Therapeutic Target for Cancer

(2014) Chunhua Zhang et al.   Anti-Cancer Agents in Medicinal Chemistry

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Regulation of the pentose phosphate pathway in cancer

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Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth

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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

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An update on dual Src/Abl inhibitors

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Phase II Trial of Saracatinib (AZD0530), an Oral SRC-inhibitor for the Treatment of Patients with Hormone Receptor-negative Metastatic Breast Cancer

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Glucose 6-Phosphate Dehydrogenase Is Regulated Through c-Src–Mediated Tyrosine Phosphorylation in Endothelial Cells

(2009) Shi Pan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic Cancer

(2009) N.V. Rajeshkumar et al.   CLINICAL CANCER RESEARCH

Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver

(2009) Rakhee S. Gupte et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Reactive oxygen species: A double-edged sword in oncogenesis

(2009) Jin-Shui Pan et al.   WORLD JOURNAL OF GASTROENTEROLOGY