Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation

(2020) Patricia Richard et al.   Autophagy

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

(2020) Alexy Promonet et al.   Nature Communications

R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1

(2019) Jia-Yu Chen et al.   Nature Protocols

Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription

(2019) Artem K Velichko et al.   NUCLEIC ACIDS RESEARCH

Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

R-Loops Promote Antisense Transcription across the Mammalian Genome

(2019) Sue Mei Tan-Wong et al.   MOLECULAR CELL

lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures

(2018) Zhongliang Zhao et al.   GENES & DEVELOPMENT

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

(2018) Christopher Grunseich et al.   MOLECULAR CELL

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

R Loops and Links to Human Disease

(2017) Patricia Richard et al.   JOURNAL OF MOLECULAR BIOLOGY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

(2017) Luis Toledo et al.   MOLECULAR CELL

R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters

(2017) Liang Chen et al.   MOLECULAR CELL

Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops

(2017) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly

(2017) Shaofeng Liu et al.   SCIENCE

Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

(2016) Lionel A. Sanz et al.   MOLECULAR CELL

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning

(2016) Zhongliang Zhao et al.   NUCLEIC ACIDS RESEARCH

lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress

(2016) Zhongliang Zhao et al.   Cell Reports

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

(2016) Caroline Townsend Stork et al.   eLife

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

(2015) Miiko Sokka et al.   NUCLEIC ACIDS RESEARCH

Nucleolar responses to DNA double-strand breaks

(2015) Dorthe Helena Larsen et al.   NUCLEIC ACIDS RESEARCH

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

Recent studies implicate the nucleolus as the major site of nuclear translation

(2014) Tina McLeod et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs

(2014) Nataša Savić et al.   Cell Stem Cell

Nucleolus and nuclear periphery: Velcro for heterochromatin

(2014) Jan Padeken et al.   CURRENT OPINION IN CELL BIOLOGY

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

pRNA

(2014) Stefanie Wehner et al.   RNA Biology

Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip

(2014) Yujia A. Chan et al.   PLoS Genetics

Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria

(2014) Aziz El Hage et al.   PLoS Genetics

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states

(2013) F. Pontvianne et al.   GENES & DEVELOPMENT

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

(2013) P. Richard et al.   GENES & DEVELOPMENT

Histone 3 S10 Phosphorylation: “Caught in the R Loop!”

(2013) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

(2013) Jessica Marinello et al.   NUCLEIC ACIDS RESEARCH

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

Epigenetic control of RNA polymerase I transcription in mammalian cells

(2012) Ingrid Grummt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription

(2012) Rong Cong et al.   NUCLEIC ACIDS RESEARCH

Repair-specific Functions of Replication Protein A

(2011) Cathy S. Hass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sub1 and RPA Associate with RNA Polymerase II at Different Stages of Transcription

(2011) Timothy W. Sikorski et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Wisely chosen paths - regulation of rRNA synthesis

(2010) Ingrid Grummt   FEBS Journal

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

(2010) K.-M. Schmitz et al.   GENES & DEVELOPMENT

Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation

(2009) Amila Suraweera et al.   HUMAN MOLECULAR GENETICS

The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus

(2008) Christine Mayer et al.   EMBO REPORTS

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS