TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas

(2020) Kuo-Hao Ho et al.   Neurotherapeutics

Tumor antigens in glioma

(2020) Takahide Nejo et al.   SEMINARS IN IMMUNOLOGY

MicroRNA-518-3p suppresses cell proliferation, invasion and migration in colorectal cancer via targeting TRIP4

(2020) Heng Yang et al.   Biochemistry and Cell Biology

DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia

(2020) Zhi-Feng Miao et al.   GASTROENTEROLOGY

Investigating Glioblastoma Response to Hypoxia

(2020) Agathe L. Chédeville et al.   Biomedicines

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma

(2019) Martha Foltyn et al.   BRITISH JOURNAL OF CANCER

TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling

(2019) Yilin Che et al.   CANCER LETTERS

A novel rapamycin analog is highly selective for mTORC1 in vivo

(2019) Katherine H. Schreiber et al.   Nature Communications

Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment

(2018) Ching-Ann Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Tumor-Promoting Role of TRIP4 in Melanoma Progression and its Involvement in Response to BRAF-Targeted Therapy

(2018) Jiaojiao Hao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

(2018) Indira Tirado-Hurtado et al.   Frontiers in Oncology

Novel ASCC1 mutations causing prenatal-onset muscle weakness with arthrogryposis and congenital bone fractures

(2018) Johann Böhm et al.   JOURNAL OF MEDICAL GENETICS

An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms

(2017) Mohd Rehan   JOURNAL OF CELLULAR BIOCHEMISTRY

Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer

(2017) Michael A. Gordon et al.   MOLECULAR CANCER THERAPEUTICS

The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies

(2017) Changbin Zhu et al.   NEURO-ONCOLOGY

In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies

(2017) Joseph A. Pinto et al.   Scientific Reports

Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures

(2016) Ellen Knierim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

REDD1/DDIT4-Independent mTORC1 Inhibition and Apoptosis by Glucocorticoids in Thymocytes

(2014) Nicholas C. Wolff et al.   MOLECULAR CANCER RESEARCH

Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development

(2014) Hee Min Yoo et al.   MOLECULAR CELL

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells

(2011) Bin Chang et al.   CELL CYCLE

REDD1, a new Ras oncogenic effector

(2011) Elizabeth R. Smith et al.   CELL CYCLE

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1

(2009) Lianqin Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT