Journal
FOOD CHEMISTRY
Volume 360, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129999
Keywords
Prunus avium; Sweet cherries; Petioles; LC-MS; Phenols; Antiangiogenic
Funding
- Fondi di Ateneo, University of Pisa [PRA_2017_30]
- Regional Council of Campania Region, entitled Campania OncoTerapieCombattere la resistenza tumorale: piattaforma integrate multidisciplinare per un approccio tecnologico innovativo alle oncoterapie
Ask authors/readers for more resources
This study compared the chemical composition and antiangiogenic activity of cherry fruits and petioles from six ancient Italian Prunus avium L. varieties. It was found that high levels of phenolic compounds were present in both fruits and petioles, with petiole extracts showing stronger radical scavenging activity due to their higher polyphenolic content. Certain varieties exhibited the best antiangiogenic response, with rutin and cyanidin 3-O-rutinoside identified as the most promising bioactive compounds through bioinformatic studies. Sweet cherry varieties were confirmed as valuable sources of phenols with potential angiomodulator properties.
In this study, cherry fruits and petioles from six ancient Italian Prunus avium L. varieties (Ferrovia, Capellina, Morellina, Ciambellana, Napoletana, and Bianca), were compared by chemical and bioinformatic analyses and evaluated for their antiangiogenic activity. The highest levels of total phenols and flavonoids were found in Napoletana petioles, and Morellina and Capellina fruits. HPLC-PDA-MS analyses showed similar phenolic profiles for all fruit extracts, with cyanidin-3-O-rutinoside, flavonols glycosides, and quinic acid derivatives as major components. Flavonoid glycosides were found in all petiole extracts, while proanthocyanidins B type were predominant in Capellina, Napoletana and Bianca. Accordingly to their higher polyphenolic content, petiole extracts exhibited stronger radical scavenging activity compared to the fruits. The best antiangiogenic response was exhibited by Morellina, Ferrovia, and Ciambellana petiole extracts, and by Ferrovia, Morellina, and Capellina fruit extracts; by bioinformatic studies rutin and cyanidin 3-O-rutinoside were recognised as the best candidate bioactive compounds. In conclusion, sweet cherry varietes were confirmed as valuable sources of phenols, showing also potential angiomodulator properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
