Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19

The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2

(2021) Shagufta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

(2021) Jingxin Qiao et al.   SCIENCE

COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention

(2021) Anshika Sharma et al.   Viruses-Basel

Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

(2021) Chun-Hui Zhang et al.   ACS Central Science

Potential drug targets of SARS-CoV-2: From genomics to therapeutics

(2021) Anas Shamsi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

(2021) Chang Liu et al.   CELL

The origins and potential future of SARS-CoV-2 variants of concern in the evolving COVID-19 pandemic

(2021) Sarah P. Otto et al.   CURRENT BIOLOGY

Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening

(2021) Yuan Xiong et al.   FITOTERAPIA

Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms

(2021) Yuan Xiong et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro)

(2021) Sang Hoon Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies

(2021) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

How the coronavirus infects cells — and why Delta is so dangerous

(2021) Megan Scudellari   NATURE

SARS-CoV-2 variants of concern are emerging in India

(2021) Jasdeep Singh et al.   NATURE MEDICINE

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant

(2021) Jamie Lopez Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

(2021) Maya G. Deshmukh et al.   STRUCTURE

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

(2021) Haixia Su et al.   Nature Communications

Original Hosts, Clinical Features, Transmission Routes, and Vaccine Development for Coronavirus Disease (COVID-19)

(2021) Ting Wu et al.   Frontiers in Medicine

Forecasting fully vaccinated people against COVID-19 and examining future vaccination rate for herd immunity in the US, Asia, Europe, Africa, South America, and the World

(2021) Pınar Cihan   APPLIED SOFT COMPUTING

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C–H Activation and Relay Diels–Alder Reaction

(2020) Dingding Gao et al.   ORGANIC LETTERS

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy

(2020) Bhupesh Goyal et al.   ACS Combinatorial Science

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

(2020) Chunlong Ma et al.   CELL RESEARCH

The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020

(2020) Yuzhi Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genomic and proteomic mutation landscapes of SARS‐CoV‐2

(2020) Christian Luke D. C. Badua et al.   JOURNAL OF MEDICAL VIROLOGY

Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease

(2020) Qingxin Li et al.   Microorganisms

Design, synthesis and biological evaluation of indanone–chalcone hybrids as potent and selective hCES2A inhibitors

(2020) Peng-Chao Huo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

10 years into the resurgence of covalent drugs

(2020) Elena De Vita   Future Medicinal Chemistry

Proton-Coupled Conformational Activation of SARS Coronavirus Main Proteases and Opportunity for Designing Small-Molecule Broad-Spectrum Targeted Covalent Inhibitors

(2020) Neha Verma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism

(2019) Yun-Qing Song et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

(2018) Miloš Erak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Halo carbonyls enable meta selective primary, secondary and tertiary C–H alkylations by ruthenium catalysis

(2017) Andrew J. Paterson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Modular synthesis of simple cycloruthenated complexes with state-of-the-art performance in p-type DSCs

(2016) Felix Brunner et al.   Journal of Materials Chemistry C