Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists

The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics

(2021) Elizabeth Cash et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

(2020) Lalgudi S. Harikrishnan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Opportunities for Small Molecules in Cancer Immunotherapy

(2020) Sabina Y. van der Zanden et al.   TRENDS IN IMMUNOLOGY

Design, Synthesis, and Biological Evaluation of Retinoic-Acid-Related Orphan Receptor γt (RORγt) Agonist -Structure-based functionality switching approach from in house RORγt inverse agonist to RORγt agonist-

(2019) Tomoya Yukawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase 1 Open-Label, Multicenter Study of First-in-Class RORγ Agonist LYC-55716: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity

(2019) Devalingam Mahalingam et al.   CLINICAL CANCER RESEARCH

Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists

(2019) Yan Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases

(2019) Nannan Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy

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Beyond death and dying: how Chinese spouses navigate the final days with their loved ones suffering from terminal cancer

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Synthetic RORγt Agonists Enhance Protective Immunity

(2016) Mi Ra Chang et al.   ACS Chemical Biology

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

(2016) Christelle Doebelin et al.   ChemMedChem

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

(2016) Douglas J. Marcotte et al.   BMC STRUCTURAL BIOLOGY

Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

(2014) Benjamin P. Fauber et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc)

(2014) Benjamin P. Fauber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

(2014) Olivier René et al.   ACS Medicinal Chemistry Letters

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY