Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold

Application of MM-PBSA Methods in Virtual Screening

(2020) Giulio Poli et al.   MOLECULES

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

(2020) Carlotta Granchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2018) Mojgan Aghazadeh Tabrizi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

(2018) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors

(2018) Jumpei Aida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

(2017) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2016) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

(2014) Gloria Hernández-Torres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and characterization of a new reversible MAGL inhibitor

(2014) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

(2012) Sudeshna Ghosh et al.   LIFE SCIENCES

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay

(2008) Giulio G. Muccioli et al.   CHEMBIOCHEM

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review

(2008) I SVIZENSKA et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR