The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann–Pick C1-Like 1

Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo

(2018) Suwen Liu et al.   FOOD RESEARCH INTERNATIONAL

Luteolin alleviates cardiac ischemia/reperfusion injury in the hypercholesterolemic rat via activating Akt/Nrf2 signaling

(2018) Jin-Ting Yang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols

(2018) Lijun Wang et al.   PHYTOMEDICINE

Luteolin decreases atherosclerosis in LDL receptor‑deficient mice via a mechanism including decreasing AMPK‑SIRT1 signaling in macrophages

(2018) Jiang Li et al.   Experimental and Therapeutic Medicine

Luteolin Prevents Cardiometabolic Alterations and Vascular Dysfunction in Mice With HFD-Induced Obesity

(2018) Daniela Gentile et al.   Frontiers in Pharmacology

Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review

(2017) CS Paththinige et al.   Lipids in Health and Disease

Effect of luteolin on the expression of intestinal cholesterol transporters

(2017) Mana Ogawa et al.   Journal of Functional Foods

The Flavone Luteolin Inhibits Liver X Receptor Activation

(2016) Vera Francisco et al.   JOURNAL OF NATURAL PRODUCTS

Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte Nuclear Factor 4α

(2015) Juan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

(2015) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells

(2015) Tsz Yan Wong et al.   PLoS One

NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy

(2015) Tappei Takada et al.   Science Translational Medicine

Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice

(2014) Gaigai Liu et al.   JOURNAL OF NUTRITION

Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann–Pick C1-Like 1 in Caco-2 Cells and Rats

(2014) Mari Nekohashi et al.   PLoS One

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

(2013) Pei-Shan Li et al.   NATURE MEDICINE

Chrysin and Luteolin Attenuate Diabetes-Induced Impairment in Endothelial-Dependent Relaxation: Effect on Lipid Profile, AGEs and NO Generation

(2013) Hany M. El-Bassossy et al.   PHYTOTHERAPY RESEARCH

Dietary Patterns in Asian Indians in the United States: An Analysis of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Study

(2013) Meghana D. Gadgil et al.   Journal of the Academy of Nutrition and Dietetics

Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet

(2012) Yintong Liang et al.   EUROPEAN JOURNAL OF NUTRITION

Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes

(2012) Xuefeng Xia et al.   HEPATOLOGY

Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy

(2012) Guoguang Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression

(2012) Dan Feng et al.   Lipids in Health and Disease

Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes

(2012) Bolin Qin et al.   NUTRITION

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

(2011) Lin Jia et al.   Annual Review of Physiology

The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake

(2011) Jin-Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75

(2011) Diane M. Harris et al.   Metabolomics

Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT

(2010) Fadi Annaba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NPC1L1 and cholesterol transport

(2010) Jenna L. Betters et al.   FEBS LETTERS

Black-Tea Polyphenols Decrease Micellar Solubility of Cholesterol in Vitro and Intestinal Absorption of Cholesterol in Rats

(2010) Ikuo Ikeda et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Human NPC1L1 Expression is Positively Regulated by PPARα

(2010) Yuki Iwayanagi et al.   PHARMACEUTICAL RESEARCH

Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3

(2010) Marisa F. Azevedo et al.   PHYTOTHERAPY RESEARCH

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

(2010) L. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niemann–Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter

(2009) Harry R. Davis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

(2008) Liang Ge et al.   Cell Metabolism

Niemann-Pick C1-Like 1 Mediates  -Tocopherol Transport

(2008) K. Narushima et al.   MOLECULAR PHARMACOLOGY

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

(2008) A. B. Weinglass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA