The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression

The Impact of Disease Comorbidities in Alzheimer's Disease

(2021) Jose A. Santiago et al.   Frontiers in Aging Neuroscience

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

(2021) Michele Rossi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses

(2020) Agnieszka Brzezińska et al.   Current Alzheimer Research

The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer’s Disease: A Preclinical Study in APP/PS1 Transgenic Mice

(2020) Hao Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial

(2018) Davangere P. Devanand et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer’s Disease Agents

(2018) Yixiang Xu et al.   ACS Chemical Neuroscience

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

(2018) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity

(2017) Baoli Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo

(2017) Shuaishuai Ni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study

(2017) Jorge Browne et al.   BMJ Open

The role of 5-HT receptors in depression

(2017) Christine N. Yohn et al.   Molecular Brain

Psychotropic Drug Development Strategies that Target Neuropsychiatric Etiologies in Alzheimer's and Parkinson's Diseases

(2016) Cornelis J. Van der Schyf   DRUG DEVELOPMENT RESEARCH

Multi-target therapeutics for neuropsychiatric and neurodegenerative disorders

(2016) Priya Bawa et al.   DRUG DISCOVERY TODAY

The 5-HT1A receptor in Major Depressive Disorder

(2016) Joshua Kaufman et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

(2016) Qing-Fei Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents

(2016) Xiaokang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer´s Disease associated with Psychiatric Comorbidities

(2015) Michelle L. Garcez et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

The Prevalence of Depression in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Song Chi et al.   Current Alzheimer Research

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

(2015) Christophe Rochais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Depression associated with dementia

(2015) H. Gutzmann et al.   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Antipsychotics, Other Psychotropics, and the Risk of Death in Patients With Dementia

(2015) Donovan T. Maust et al.   JAMA Psychiatry

Behavioral and Psychological Symptoms in Alzheimer’s Disease

(2014) Xiao-Ling Li et al.   Biomed Research International

The Epidemiological Modelling of Major Depressive Disorder: Application for the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLoS One

Behavioral and Psychological Symptoms of Dementia

(2012) J. Cerejeira et al.   Frontiers in Neurology

Depression and risk of developing dementia

(2011) Amy L. Byers et al.   Nature Reviews Neurology

5-HT1A receptor-regulated signal transduction pathways in brain

(2010) Abigail M. Polter et al.   CELLULAR SIGNALLING

Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

(2010) Narihiro Toda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies

(2010) Inge Klinkenberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vilazodone: A 5-HT1AReceptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders

(2009) Lee A. Dawson et al.   CNS Neuroscience & Therapeutics

Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression

(2009) Arif Khan   EXPERT OPINION ON INVESTIGATIONAL DRUGS

5-HT1A receptor function in major depressive disorder

(2009) Jonathan Savitz et al.   PROGRESS IN NEUROBIOLOGY

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY