Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

Combretastatin A4-derived payloads for antibody-drug conjugates

(2021) Rong Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

(2019) Ilhem Khelifi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1

(2019) Shan Pan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Divergent and Orthogonal Approach to Carbazoles and Pyridoindoles from Oxindoles via Indole Intermediates

(2018) Tirtha Mandal et al.   ORGANIC LETTERS

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

(2018) Timothée Naret et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anticancer properties of Iso CombretaQuinolines as potent tubulin assembly inhibitors

(2017) Ilhem Khelifi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents

(2017) Zaki S. Seddigi et al.   MedChemComm

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer

(2016) Tourin Bzeih et al.   CHEMICAL COMMUNICATIONS

Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization

(2016) Christine A. Herdman et al.   MedChemComm

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity

(2015) Mohamed Ali Soussi et al.   ChemMedChem

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents

(2015) Dolor Renko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

(2015) Carmen Jiménez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transition-Metal-Free Hydration of Nitriles Using Potassium tert-Butoxide under Anhydrous Conditions

(2015) Ganesh Chandra Midya et al.   JOURNAL OF ORGANIC CHEMISTRY

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

(2014) Andrei Maksimenko et al.   ACS Nano

Discovery of azaisoerianin derivatives as potential antitumors agents

(2014) Mohamed Ali Soussi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization

(2013) Olivier Provot et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted iso combretastatin A-4 analogs

(2013) Evelia Rasolofonjatovo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity

(2012) Evelia Rasolofonjatovo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An amino-benzosuberene analogue that inhibits tubulin assembly and demonstrates remarkable cytotoxicity

(2012) Rajendra P. Tanpure et al.   MedChemComm

The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites

(2011) Mohamed Ali Soussi et al.   ChemMedChem

Discovery of Isoerianin Analogues as Promising Anticancer Agents

(2011) Samir Messaoudi et al.   ChemMedChem

B-Ring-Modified isoCombretastatin A-4 Analogues Endowed with Interesting Anticancer Activities

(2011) Abdallah Hamze et al.   ChemMedChem

Developments of Combretastatin A-4 Derivatives as Anticancer Agents

(2011) Y. Shan Shan et al.   CURRENT MEDICINAL CHEMISTRY

Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model

(2010) Cheng-Huang Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficient and general synthesis of oxazino[4,3-a]indoles by cascade addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl sulfonium salts

(2010) Jing An et al.   CHEMICAL COMMUNICATIONS

Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

(2009) Raquel Álvarez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation of 1,1-Diarylethylenes as a Novel Class of Antimitotic Agents

(2009) Abdallah Hamze et al.   ChemMedChem

Isocombretastatins A versus Combretastatins A: The ForgottenisoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent

(2009) Samir Messaoudi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy

(2008) Madhavi Sriram et al.   BIOORGANIC & MEDICINAL CHEMISTRY

One-pot hydrosilylation–protodesilylation of functionalized diarylalkynes: a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4

(2007) Anne Giraud et al.   TETRAHEDRON LETTERS