Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 88, Pages 13027-13030Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07666a
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Funding
- Lebanese University
- CNRS
- University Paris-Sud
- La Ligue Contre le Cancer'' throughout an Equipe Labellisee grant
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A convergent and effective synthesis of 3-aryl-indoles, 2,3-diaryl indoles, and (1-arylvinyl) carbazoles from a one-pot sequence involving the coupling of N-tosylhydrazones with ortho-nitro-haloarenes followed by a cyclization has been developed. Compound 5i exhibits excellent antiproliferative activity in the low nM range against colon cancer cell lines.
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