Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR

MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma

(2021) Jun Yan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents

(2020) Abdallah Hamze et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system

(2020) Jichun Yang et al.   BIOMATERIALS

Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors

(2020) Haleema Sadia Malik et al.   JOURNAL OF NATURAL PRODUCTS

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation

(2020) Shannon Pecnard et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains

(2019) Fatima Naaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of thioredoxin system in cancer: strategy for cancer therapy

(2019) Jin-Jing Jia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

(2019) Yanqing Pang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic

(2018) Xiaoyuan Ren et al.   FREE RADICAL BIOLOGY AND MEDICINE

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

(2018) Jianhong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents

(2018) Baijiao An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microtubule dynamics: an interplay of biochemistry and mechanics

(2018) Gary J. Brouhard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Indole–Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

(2018) Hui Cong et al.   MOLECULAR PHARMACEUTICS

Towards further understanding the structural requirements of combretastatin-like chalcones as inhibitors of microtubule polymerization

(2018) Naveen Dhingra et al.   Current Computer-Aided Drug Design

Microtubules: From understanding their dynamics to using them as potential therapeutic targets

(2018) Yaron Ilan   JOURNAL OF CELLULAR PHYSIOLOGY

Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization

(2017) Jun Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

(2017) Yanqing Pang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents

(2017) Shun Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors

(2017) Baijiao An et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thioredoxin reductase inhibitors: a patent review

(2016) Baoxin Zhang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo

(2016) Jun Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

(2016) María-Jesús Pérez-Pérez et al.   JOURNAL OF MEDICINAL CHEMISTRY

The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

(2016) Shun Zhang et al.   RSC Advances

A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells

(2015) Jun Yan et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents

(2015) Jun Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

(2015) Jinhui Hu et al.   MedChemComm

Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents

(2015) Jun Yan et al.   RSC Advances

The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents

(2014) Jianfei Sheng et al.   RSC Advances

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue

(2011) Xiaojie Zhu et al.   ORAL ONCOLOGY

Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones

(2009) Sylvie Ducki et al.   BIOORGANIC & MEDICINAL CHEMISTRY