Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise

Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform

(2021) Louise Conilh et al.   Pharmaceuticals

Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer

(2020) Yuki Tsuchihashi et al.   MOLECULAR PHARMACEUTICS

Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy

(2020) David M. Goldenberg et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Passive and active targeting strategies for the delivery of the camptothecin anticancer drug: a review

(2020) Anindita Behera et al.   Environmental Chemistry Letters

F10, a new camptothecin derivative, was identified as a new orally–bioavailable, potent antitumor agent

(2020) Shu Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Machine Learning Method for Drug Combination Prediction

(2020) Jiang Li et al.   Frontiers in Genetics

Antibody–Drug Conjugates: The Last Decade

(2020) Nicolas Joubert et al.   Pharmaceuticals

Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents

(2019) Zi-Long Song et al.   NATURAL PRODUCT RESEARCH

Prediction of irinotecan toxicity in metastatic colorectal cancer patients based on machine learning models with pharmacokinetic parameters

(2019) Esther Oyaga-Iriarte et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Synthesis and antitumor activity of pyrano[3,2-i]-fused camptothecin derivatives

(2019) Bihong Hong et al.   MEDICINAL CHEMISTRY RESEARCH

A Bayesian machine learning approach for drug target identification using diverse data types

(2019) Neel S. Madhukar et al.   Nature Communications

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin

(2019) Cheng-Jie Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on camptothecin analogs with promising cytotoxic profile

(2018) Sk. Abdul Amin et al.   Anti-Cancer Agents in Medicinal Chemistry

A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo

(2018) Jianling Zou et al.   Cell Death & Disease

Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents

(2018) Cheng-Ting Zi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fungicidal activities of camptothecin semisynthetic derivatives against Colletotrichum gloeosporioides in vitro and in mango fruit

(2018) Gang Feng et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

DNA Topoisomerase 1 Structure-BASED Design, Synthesis, Activity Evaluation and Molecular Simulations Study of New 7-Amide Camptothecin Derivatives Against Spodoptera frugiperda

(2018) Zhiyan Jiang et al.   Frontiers in Chemistry

Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

(2017) Di-Zao Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy

(2017) Nicolas Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives

(2017) Chao Zheng et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

(2017) Pablo Botella et al.   JOURNAL OF CONTROLLED RELEASE

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

(2017) Yanru Xin et al.   Cancer Biology & Medicine

Camptothecin-based nanodrug delivery systems

(2017) Wen Yan et al.   Cancer Biology & Medicine

Impact of Chemotherapy Dose Intensity on Cancer Patient Outcomes

(2017) Gary H. Lyman   Journal of the National Comprehensive Cancer Network

Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205

(2016) Di Wu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Low toxic and high soluble camptothecin derivative 2–47 effectively induces apoptosis of tumor cells in vitro

(2016) Yao Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytoskeletal interference – A new mode of action for the anticancer drugs camptothecin and topotecan

(2016) Xiaojuan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel 20(S)-sulfonylamidine derivatives of camptothecin and the use thereof as a potent antitumor agent: a patent evaluation of WO2015048365 (A1)

(2016) Giovanni Luca Beretta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The safety and efficacy of Onivyde (irinotecan liposome injection) for the treatment of metastatic pancreatic cancer following gemcitabine-based therapy

(2016) Frank C. Passero et al.   Expert Review of Anticancer Therapy

Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine

(2016) Alfredo Garcia et al.   ORGANIC LETTERS

Mitigating exacerbation of Irinotecan-induced gastrointestinal toxicity in combination with an ATM inhibitor in the rat

(2016) A. Cronin et al.   TOXICOLOGY LETTERS

Biotin decorated PLGA nanoparticles containing SN-38 designed for cancer therapy

(2016) Mozhdeh Mehdizadeh et al.   Artificial Cells Nanomedicine and Biotechnology

Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments

(2016) Rachel M. McQuade et al.   Frontiers in Pharmacology

Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids

(2015) Gregory S. Hamilton   BIOLOGICALS

Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor

(2015) Hanyi Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents

(2015) Lei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Perspectives on Biologically Active Camptothecin Derivatives

(2015) Ying-Qian Liu et al.   MEDICINAL RESEARCH REVIEWS

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

(2015) David Westover et al.   Molecular Cancer

Camptothecin-7-yl-methanthiole: Semisynthesis and Biological Evaluation

(2012) Michael S. Christodoulou et al.   ChemMedChem

CoMFA QSAR models of camptothecin analogues based on the distinctive SAR features of combined ABC, CD and E ring substitutions

(2012) Bastikar Virupaksha et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Cancer Therapies Utilizing the Camptothecins: A Review of thein VivoLiterature

(2010) Vincent J. Venditto et al.   MOLECULAR PHARMACEUTICS

Review role of topotecan in gynaecological cancers: Current indications and perspectives

(2009) Domenica Lorusso et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents

(2008) Ying-Qian Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants

(2008) S. Sirikantaramas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA