Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters

Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models

(2021) Gabriel Gonzalez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triphenylphosphonium Analogues of Betulin and Betulinic Acid with Biological Activity: A Comprehensive Review

(2019) Mirosława Grymel et al.   JOURNAL OF NATURAL PRODUCTS

2-Deoxyglycoside Conjugates of Lupane Triterpenoids with High Cytotoxic Activity—Synthesis, Activity, and Pharmacokinetic Profile

(2019) Pavla Perlikova et al.   BIOCONJUGATE CHEMISTRY

Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research

(2019) Jiri Hodon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid

(2019) Lucie Borková et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic applications of betulinic acid nanoformulations

(2018) Ankit Saneja et al.   Annals of the New York Academy of Sciences

Effect of betulinic acid and its ionic derivatives on M-MuLV replication

(2018) Jasmine Phillips et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution

(2018) Sona Krajcovicova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis

(2018) Uladzimir Bildziukevich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM

(2018) Jan Pokorny et al.   Future Medicinal Chemistry

Triterpenoids

(2018) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Prodrugs of triterpenoids and their derivatives

(2017) Meng Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations

(2017) Sven Sommerwerk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016)

(2017) Hidayat Hussain et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors

(2017) Elmira F. Khusnutdinova et al.   MEDICINAL CHEMISTRY RESEARCH

New Pharmacological Opportunities for Betulinic Acid

(2017) José Ríos et al.   PLANTA MEDICA

Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas

(2017) Annemarie Ackermann et al.   Oncotarget

Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity

(2016) Jizhen Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

Synthesis and biological evaluation of novel pentacyclic triterpene α -cyclodextrin conjugates as HCV entry inhibitors

(2016) Sulong Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oleanolic acid derivatives for pharmaceutical use: a patent review

(2016) Chao Lin et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Betulinic acid and the pharmacological effects of tumor suppression

(2016) Xia Zhang et al.   Molecular Medicine Reports

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases

(2016) MURTALA BINDAWA ISAH et al.   PARASITOLOGY

Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin

(2015) Miroslav Soural et al.   BIOCONJUGATE CHEMISTRY

Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds

(2015) Jana Wiemann et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Betulinic acid and its derivatives: a patent review (2008 – 2013)

(2014) René Csuk   EXPERT OPINION ON THERAPEUTIC PATENTS

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

(2014) Lin Dai et al.   Polymer Chemistry

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

(2014) Xiannu Jin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Betulin-Betulinic Acid Natural Product Based Analogs as Anti-Cancer Agents

(2013) Subash Jonnalagadda et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis of selectively deuterated and tritiated lupane derivatives with cytotoxic activity

(2013) Martin Vlk et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry

(2012) Ibrahim D. Bori et al.   TETRAHEDRON LETTERS

Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines

(2011) Aurelie Bourderioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiprotozoal activity of Betulinic acid derivatives

(2009) D.B. Domínguez-Carmona et al.   PHYTOMEDICINE