Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 19, Pages 4957-4966Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201706093
Keywords
cytotoxicity; dyes/pigments; fluorescence microscopy; solid-phase synthesis; terpenoids
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Funding
- Czech Science Foundation [15-05620S]
- Technology Agency of the Czech Republic [TE01020028]
- Czech Ministry of Education, Youth and Sports [LO1304, LM2015063]
- Palacky University [IGA_PrF_2017_009, IGA_LF_2017_026, IGA_LF_2017_028]
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A solid-phase synthetic (SPS) method was developed for the preparation of BODIPY-labeled bioactive compounds that allows for fast and simple synthesis of conjugates for use in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.
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