Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents

Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis

(2021) Zhaoxing Chu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model

(2020) Zhou Zeng et al.   Aging-US

A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists

(2020) Wenwu Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

(2020) Dennis W. Choi   Frontiers in Neuroscience

Hypoxic preconditioning relieved ischemic cerebral injury by promoting immunomodulation and microglia polarization after middle cerebral artery occlusion in rats

(2019) Lu Huang et al.   BRAIN RESEARCH

Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model

(2019) Masahiro Fuwa et al.   Scientific Reports

Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1- b ]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents

(2018) Linkui Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Global Burden of Stroke

(2018) Mira Katan et al.   SEMINARS IN NEUROLOGY

N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression

(2018) Ling-Er Huang et al.   Scientific Reports

Targeting NMDA receptors in stroke: new hope in neuroprotection

(2018) Qiu Jing Wu et al.   Molecular Brain

Current advances in ischemic stroke research and therapies

(2018) Derek Barthels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Left-right asymmetry influenced the infarct volume and neurological dysfunction following focal middle cerebral artery occlusion in rats

(2018) Zhiyong Zhai et al.   Brain and Behavior

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors

(2017) Brice Mullier et al.   NEUROPHARMACOLOGY

MRI Guiding of the Middle Cerebral Artery Occlusion in Rats Aimed to Improve Stroke Modeling

(2017) Ilya L. Gubskiy et al.   Translational Stroke Research

Reversible Disruption of Neuronal Mitochondria by Ischemic and Traumatic Injury Revealed by Quantitative Two-Photon Imaging in the Neocortex of Anesthetized Mice

(2016) Mikhail Kislin et al.   JOURNAL OF NEUROSCIENCE

Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents

(2015) Joe S. Matarlo et al.   BIOCHEMISTRY

Safety Surveillance of Traditional Chinese Medicine: Current and Future

(2015) Shwu-Huey Liu et al.   DRUG SAFETY

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

(2015) Hongjie Yuan et al.   NEURON

3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia

(2014) Hanqin Wang et al.   Neural Regeneration Research

N-Methyl D-Aspartate (NMDA) Receptor Antagonists and Memantine Treatment for Alzheimer’s Disease, Vascular Dementia and Parkinson’s Disease

(2013) David Olivares et al.   Current Alzheimer Research

Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

(2012) Jian Li et al.   Evidence-based Complementary and Alternative Medicine

A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder

(2012) Lobna Ibrahim et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Synthesis and Biological Characterization of 3-Substituted 1H-Indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate Receptors. Part 2

(2012) Rosaria Gitto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Characterization of 3-Substituted-1H-indoles as Ligands of GluN2B-ContainingN-Methyl-d-aspartate Receptors

(2011) Rosaria Gitto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes

(2008) Mathew J Reeves et al.   LANCET NEUROLOGY