Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers

Plastic Additives in Ambient Fine Particulate Matter in the Pearl River Delta, China: High-Throughput Characterization and Health Implications

(2021) Xiaotu Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

(2021) Jördis Klose et al.   CELL BIOLOGY AND TOXICOLOGY

Pregnancy exposure to organophosphate esters and the risk of attention-deficit hyperactivity disorder in the Norwegian mother, father and child cohort study

(2021) Giehae Choi et al.   ENVIRONMENT INTERNATIONAL

Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro

(2020) Xiali Zhong et al.   ARCHIVES OF TOXICOLOGY

Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China

(2020) Dan Luo et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparing the use of silicone wristbands, hand wipes, and dust to evaluate children's exposure to flame retardants and plasticizers

(2020) Stephanie C Hammel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Elevated Concentrations of Semivolatile Organic Compounds in Social Housing Multiunit Residential Building Apartments

(2020) Yuchao Wan et al.   Environmental Science & Technology Letters

Multi-exposures to suspected endocrine disruptors in electronic waste recycling workers: Associations with thyroid and reproductive hormones

(2020) Sabrina Gravel et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain

(2020) Kylie D Rock et al.   TOXICOLOGICAL SCIENCES

Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain

(2020) Xiaoshan Liu et al.   CHEMOSPHERE

Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure

(2020) Minmin Hou et al.   ENVIRONMENT INTERNATIONAL

Maternal exposure to organophosphate flame retardants alters locomotor and anxiety-like behavior in male and female adult offspring

(2020) K.R. Wiersielis et al.   HORMONES AND BEHAVIOR

Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression

(2020) Samantha Adams et al.   REPRODUCTIVE TOXICOLOGY

Global responses to tris(1-chloro-2-propyl)phosphate (TCPP) in rockfish Sebastes schlegeli using integrated proteomic and metabolomic approach

(2020) Chenglong Ji et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model

(2020) Helena T. Hogberg et al.   ARCHIVES OF TOXICOLOGY

Organophosphate Flame Retardants Excite Arcuate Melanocortin Circuitry and Increase Neuronal Sensitivity to Ghrelin in Adult Mice

(2020) Gwyndolin M Vail et al.   ENDOCRINOLOGY

Young infants’ exposure to organophosphate esters: Breast milk as a potential source of exposure

(2020) Stephanie C. Hammel et al.   ENVIRONMENT INTERNATIONAL

Brominated and phosphate flame retardants from interior and surface dust of personal computers: insights into sources for human dermal exposure

(2020) Lehuan Yu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice

(2020) Sabrina N. Walley et al.   JOURNAL OF APPLIED TOXICOLOGY

Shifting Developmental Trajectories During Critical Periods of Brain Formation

(2020) Nathalie Dehorter et al.   Frontiers in Cellular Neuroscience

Exposure to organophosphate ester flame retardants and plasticizers during pregnancy: Thyroid endocrine disruption and mediation role of oxidative stress

(2020) Yiming Yao et al.   ENVIRONMENT INTERNATIONAL

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

(2020) Samia Selmi-Ruby et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Organophosphate Esters in the Canadian Arctic Ocean

(2020) Roxana Sühring et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The potential connections of adverse outcome pathways with the hazard identifications of typical organophosphate esters based on toxicity mechanisms

(2020) Zhenfei Yan et al.   CHEMOSPHERE

Tris (1-chloro-2-propyl) phosphate exposure to zebrafish causes neurodevelopmental toxicity and abnormal locomotor behavior

(2020) Min Xia et al.   SCIENCE OF THE TOTAL ENVIRONMENT

In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants

(2020) Qipeng Shi et al.   JOURNAL OF HAZARDOUS MATERIALS

Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays

(2019) Timothy J Shafer et al.   TOXICOLOGICAL SCIENCES

Identification of Photoinitiators, Including Novel Phosphine Oxides, and Their Transformation Products in Food Packaging Materials and Indoor Dust in Canada

(2019) Runzeng Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Polyurethane heat preservation materials: The significant sources of organophosphorus flame retardants

(2019) Yan Wang et al.   CHEMOSPHERE

Associations between urinary organophosphate ester metabolites and measures of adiposity among U.S. children and adults: NHANES 2013–2014

(2019) M. Boyle et al.   ENVIRONMENT INTERNATIONAL

A Review of a Class of Emerging Contaminants: The Classification, Distribution, Intensity of Consumption, Synthesis Routes, Environmental Effects and Expectation of Pollution Abatement to Organophosphate Flame Retardants (OPFRs)

(2019) Jiawen Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity

(2019) Jinpeng Li et al.   NEUROTOXICOLOGY

Prenatal exposure to organophosphate esters and behavioral development in young children in the Pregnancy, Infection, and Nutrition Study

(2019) Brett T Doherty et al.   NEUROTOXICOLOGY

Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models

(2019) Angelica Rocha et al.   NEUROTOXICOLOGY

Development and analysis of an adverse outcome pathway network for human neurotoxicity

(2019) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Organophosphorus Flame Retardants and Plasticizers in Breast Milk from the United States

(2019) Jing Ma et al.   Environmental Science & Technology Letters

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

(2019) Michele A. La Merrill et al.   Nature Reviews Endocrinology

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

(2019) Sagi Enicole A. Gillera et al.   NEUROTOXICOLOGY AND TERATOLOGY

Organophosphate Ester Flame Retardants: Are They a Regrettable Substitution for Polybrominated Diphenyl Ethers?

(2019) Arlene Blum et al.   Environmental Science & Technology Letters

Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish

(2019) Ruiwen Li et al.   ENVIRONMENT INTERNATIONAL

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

(2019) Michelle Leemans et al.   Frontiers in Endocrinology

1 H-nuclear magnetic resonance metabolomics revealing the intrinsic relationships between neurochemical alterations and neurobehavioral and neuropathological abnormalities in rats exposed to tris(2-chloroethyl)phosphate

(2018) Weiqun Yang et al.   CHEMOSPHERE

Urinary metabolites of organophosphate esters: Concentrations and age trends in Australian children

(2018) Chang He et al.   ENVIRONMENT INTERNATIONAL

Exposure to organophosphate flame retardant chemicals in the U.S. general population: Data from the 2013–2014 National Health and Nutrition Examination Survey

(2018) Maria Ospina et al.   ENVIRONMENT INTERNATIONAL

Brominated Flame Retardants and Organophosphate Esters in Preschool Dust and Children’s Hand Wipes

(2018) Kristin Larsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain

(2018) Margaret M. McCarthy et al.   PHYSIOLOGY & BEHAVIOR

Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish

(2018) Lilah Glazer et al.   TOXICOLOGICAL SCIENCES

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N -methyl- d -aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

(2018) Magdalini Sachana et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

(2018) Ellen Fritsche et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain

(2018) Kylie D Rock et al.   Endocrine Connections

Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae

(2018) Qipeng Shi et al.   AQUATIC TOXICOLOGY

NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK-3β via calcineurin in cultured immature hippocampal neurons

(2018) Ying Wang et al.   EXPERIMENTAL CELL RESEARCH

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Are cell phones an indicator of personal exposure to organophosphate flame retardants and plasticizers?

(2018) Congqiao Yang et al.   ENVIRONMENT INTERNATIONAL

Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior

(2018) Andrea C. Gore et al.   HORMONES AND BEHAVIOR

White matter damage, neuroinflammation, and neuronal integrity in HAND

(2018) Aljoharah Alakkas et al.   JOURNAL OF NEUROVIROLOGY

Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance

(2018) Ainhoa Alzualde et al.   NEUROTOXICOLOGY AND TERATOLOGY

Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study

(2018) Brett T. Doherty et al.   ENVIRONMENTAL RESEARCH

Differential exposure to organophosphate flame retardants in mother-child pairs

(2018) Elizabeth A. Gibson et al.   CHEMOSPHERE

Organophosphate flame retardants in the indoor and outdoor dust and gas-phase of Alexandria, Egypt

(2018) Mohammed A. Khairy et al.   CHEMOSPHERE

Cross-sectional study of social behaviors in preschool children and exposure to flame retardants

(2017) Shannon T. Lipscomb et al.   Environmental Health

Organophosphate Ester Flame Retardants and Plasticizers in Ocean Sediments from the North Pacific to the Arctic Ocean

(2017) Yuxin Ma et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Firemaster® 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Pparγ) on the adipocyte protein 2 (aP2) promoter

(2017) Emily W. Y. Tung et al.   PLoS One

Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα

(2017) Elizabeth A Krumm et al.   TOXICOLOGICAL SCIENCES

Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells

(2017) Theodore A. Slotkin et al.   TOXICOLOGY

Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats

(2017) Kylie R. Baldwin et al.   Scientific Reports

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes

(2016) Ying Pei et al.   BRAIN RESEARCH

Novel flame retardants: Estimating the physical–chemical properties and environmental fate of 94 halogenated and organophosphate PBDE replacements

(2016) Xianming Zhang et al.   CHEMOSPHERE

Regional comparison of organophosphate flame retardant (PFR) urinary metabolites and tetrabromobenzoic acid (TBBA) in mother-toddler pairs from California and New Jersey

(2016) Craig M. Butt et al.   ENVIRONMENT INTERNATIONAL

From Clothing to Laundry Water: Investigating the Fate of Phthalates, Brominated Flame Retardants, and Organophosphate Esters

(2016) Amandeep Saini et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Measuring Personal Exposure to Organophosphate Flame Retardants Using Silicone Wristbands and Hand Wipes

(2016) Stephanie C. Hammel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comprehensive Study of Human External Exposure to Organophosphate Flame Retardants via Air, Dust, and Hand Wipes: The Importance of Sampling and Assessment Strategy

(2016) Fuchao Xu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Organophosphate Esters in Canadian Arctic Air: Occurrence, Levels and Trends

(2016) Roxana Sühring et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Organophosphate ester flame retardant concentrations and distributions in serum from inhabitants of Shandong, China, and changes between 2011 and 2015

(2016) Yulong Ma et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Exposure to non-persistent pesticides and thyroid function: A systematic review of epidemiological evidence

(2016) Élida Campos et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity

(2016) Kristen R. Ryan et al.   NEUROTOXICOLOGY

Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity

(2016) Liwei Sun et al.   NEUROTOXICOLOGY AND TERATOLOGY

Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China

(2016) Jinjian Ding et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Editor’s Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats

(2016) Allison L. Phillips et al.   TOXICOLOGICAL SCIENCES

Placental, Matrilineal, and Epigenetic Mechanisms Promoting Environmentally Adaptive Development of the Mammalian Brain

(2016) Kevin D. Broad et al.   NEURAL PLASTICITY

Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines

(2015) Sujin Kim et al.   AQUATIC TOXICOLOGY

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

(2015) A. C. Gore et al.   ENDOCRINE REVIEWS

High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products

(2015) Kate Hoffman et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-Dichloro-2-propyl Phosphate Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae

(2015) Qiangwei Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust

(2015) Mingliang Fang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

TBBPA induces developmental toxicity, oxidative stress, and apoptosis in embryos and zebrafish larvae (Danio rerio)

(2015) Shengmin Wu et al.   ENVIRONMENTAL TOXICOLOGY

Multi-contaminant analysis of organophosphate and halogenated flame retardants in food matrices using ultrasonication and vacuum assisted extraction, multi-stage cleanup and gas chromatography–mass spectrometry

(2015) Fuchao Xu et al.   JOURNAL OF CHROMATOGRAPHY A

Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish

(2015) A.N. Oliveri et al.   NEUROTOXICOLOGY AND TERATOLOGY

Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish

(2015) Kimberly A. Jarema et al.   NEUROTOXICOLOGY AND TERATOLOGY

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity

(2015) Mamta Behl et al.   NEUROTOXICOLOGY AND TERATOLOGY

Exposures, mechanisms, and impacts of endocrine-active flame retardants

(2014) Laura V Dishaw et al.   CURRENT OPINION IN PHARMACOLOGY

Implications of Prenatal Steroid Perturbations for Neurodevelopment, Behavior, and Autism

(2014) Andrea C. Gore et al.   ENDOCRINE REVIEWS

Ligand Binding and Activation of PPAR γ by Firemaster ® 550: Effects on Adipogenesis and Osteogenesis in Vitro

(2014) Hari K. Pillai et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Metabolites of Organophosphate Flame Retardants and 2-Ethylhexyl Tetrabromobenzoate in Urine from Paired Mothers and Toddlers

(2014) Craig M. Butt et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Developmental Exposure to Organophosphate Flame Retardants Elicits Overt Toxicity and Alters Behavior in Early Life Stage Zebrafish (Danio rerio)

(2014) Laura V. Dishaw et al.   TOXICOLOGICAL SCIENCES

Impairment of Glutamate Signaling in Mouse Central Nervous System Neurons In Vitro by Tri-Ortho-Cresyl Phosphate at Noncytotoxic Concentrations

(2014) Vanessa Hausherr et al.   TOXICOLOGICAL SCIENCES

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

(2014) Scott M. Belcher et al.   TOXICOLOGY LETTERS

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Urinary Metabolites of Organophosphate Flame Retardants: Temporal Variability and Correlations with House Dust Concentrations

(2013) John D. Meeker et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Investigating a Novel Flame Retardant Known as V6: Measurements in Baby Products, House Dust, and Car Dust

(2013) Mingliang Fang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

In Ovo Effects of Two Organophosphate Flame Retardants—TCPP and TDCPP—on Pipping Success, Development, mRNA Expression, and Thyroid Hormone Levels in Chicken Embryos

(2013) Amani Farhat et al.   TOXICOLOGICAL SCIENCES

In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors

(2013) Hiroyuki Kojima et al.   TOXICOLOGY

Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish

(2012) Xiaoshan Liu et al.   AQUATIC TOXICOLOGY

Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis

(2012) Ike van der Veen et al.   CHEMOSPHERE

Novel and High Volume Use Flame Retardants in US Couches Reflective of the 2005 PentaBDE Phase Out

(2012) Heather M. Stapleton et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster®550 in Rats: An Exploratory Assessment

(2012) Heather B. Patisaul et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A transient placental source of serotonin for the fetal forebrain

(2011) Alexandre Bonnin et al.   NATURE

Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain

(2011) A. Bonnin et al.   NEUROSCIENCE

Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells

(2011) Laura V. Dishaw et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Detection of Organophosphate Flame Retardants in Furniture Foam and U.S. House Dust

(2009) Heather M. Stapleton et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The prairie vole: an emerging model organism for understanding the social brain

(2009) Lisa A. McGraw et al.   TRENDS IN NEUROSCIENCES