RIF1 and KAP1 differentially regulate the choice of inactive versus active X chromosomes

Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction

(2021) Stefano Gnan et al.   Nature Communications

SPEN integrates transcriptional and epigenetic control of X-inactivation

(2020) François Dossin et al.   NATURE

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

(2020) Verena Mutzel et al.   BIOESSAYS

Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover

(2020) Eric Aeby et al.   NATURE CELL BIOLOGY

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control

(2019) Sarah A. Peck et al.   Wiley Interdisciplinary Reviews-RNA

A symmetric toggle switch explains the onset of random X inactivation in different mammals

(2019) Verena Mutzel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

(2019) Javier Garzón et al.   Cell Reports

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products

(2018) Giulia Furlan et al.   MOLECULAR CELL

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

(2018) Andrea Coluccio et al.   Epigenetics & Chromatin

Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition

(2018) Charles A. Seller et al.   PLOS BIOLOGY

The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes

(2017) Dong Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

(2017) Maud Borensztein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation

(2017) Pishun Li et al.   NUCLEIC ACIDS RESEARCH

Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast

(2017) Tea Toteva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

(2017) Maud Borensztein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rlim -Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs

(2017) Feng Wang et al.   Cell Reports

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

(2017) Robert C. Alver et al.   Cell Reports

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)

(2017) Rasa Sukackaite et al.   Scientific Reports

Female mice lacking Xist RNA show partial dosage compensation and survive to term

(2016) Lin Yang et al.   GENES & DEVELOPMENT

RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes

(2016) Heeyoun Bunch et al.   GENOMICS

Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3

(2016) Hiromu Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program

(2016) Rossana Foti et al.   MOLECULAR CELL

Taz1-Shelterin Promotes Facultative Heterochromatin Assembly at Chromosome-Internal Sites Containing Late Replication Origins

(2016) Martin Zofall et al.   MOLECULAR CELL

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II

(2016) Ryan P. McNamara et al.   MOLECULAR CELL

Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

(2016) C.-K. Chen et al.   SCIENCE

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Drosophila Rif1 is an essential gene and controls late developmental events by direct interaction with PP1-87B

(2015) Easwaran Sreesankar et al.   Scientific Reports

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

(2014) S.-i. Hiraga et al.   GENES & DEVELOPMENT

RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast

(2014) JongDae Shin et al.   NATURE

Rif1 Regulates Initiation Timing of Late Replication Origins throughout the S. cerevisiae Genome

(2014) Jared M. Peace et al.   PLoS One

A prominent and conserved role for YY1 in Xist transcriptional activation

(2014) Mélanie Makhlouf et al.   Nature Communications

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity

(2014) Anoushka Davé et al.   Cell Reports

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

(2014) Stefano Mattarocci et al.   Cell Reports

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

(2013) Matthew D. Simon et al.   NATURE

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

(2013) Irina A Maksakova et al.   Epigenetics & Chromatin

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells

(2013) Gonçalo Castelo-Branco et al.   GENOME BIOLOGY

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse

(2013) Lucia Daxinger et al.   GENOME BIOLOGY

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

Rif1 regulates the replication timing domains on the human genome

(2012) Satoshi Yamazaki et al.   EMBO JOURNAL

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(2012) M. Hayano et al.   GENES & DEVELOPMENT

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

(2012) Cristina Gontan et al.   NATURE

A transcription factor–based mechanism for mouse heterochromatin formation

(2012) Aydan Bulut-Karslioglu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allele-specific distribution of RNA polymerase II on female X chromosomes

(2011) Katerina S. Kucera et al.   HUMAN MOLECULAR GENETICS

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

(2010) Di Tian et al.   CELL

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

(2010) Corinne Chureau et al.   HUMAN MOLECULAR GENETICS

RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation

(2009) Iris Jonkers et al.   CELL

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

(2009) Sara B.C. Buonomo et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1

(2008) Chiung-Wen Chang et al.   BMC MOLECULAR BIOLOGY

A new model for random X chromosome inactivation

(2008) J. Starmer et al.   DEVELOPMENT

Dynamic interactions between the promoter and terminator regions of the mammalianBRCA1gene

(2008) Sue Mei Tan-Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Coupling of Xist Regulation and Pluripotency

(2008) P. Navarro et al.   SCIENCE

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

(2008) J. Zhao et al.   SCIENCE