Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia

Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

(2021) Wei Wang et al.   Frontiers in Cell and Developmental Biology

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport

(2020) Servaas N. van der Burght et al.   CURRENT BIOLOGY

The molecular structure of mammalian primary cilia revealed by cryo-electron tomography

(2020) Petra Kiesel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Three-dimensional architecture of epithelial primary cilia

(2019) Shufeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly

(2019) Shoji Hata et al.   NATURE CELL BIOLOGY

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

(2018) Helen Louise May-Simera et al.   Cell Reports

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

(2018) Maren Mönnich et al.   Cell Reports

The regulation of cilium assembly and disassembly in development and disease

(2018) Lei Wang et al.   DEVELOPMENT

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

(2018) Kai He et al.   Nature Communications

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

(2017) Bram Prevo et al.   FEBS Journal

A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies

(2017) Shalabh Srivastava et al.   HUMAN MOLECULAR GENETICS

Tubulin glycylation controls primary cilia length

(2017) Sudarshan Gadadhar et al.   JOURNAL OF CELL BIOLOGY

Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release

(2017) Raquel Y. Salinas et al.   JOURNAL OF CELL BIOLOGY

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

(2017) Xiaoyu Shi et al.   NATURE CELL BIOLOGY

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis

(2016) Vincent J. Guen et al.   CELL CYCLE

The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

(2016) Lea M. Alford et al.   Cytoskeleton

Cilium assembly and disassembly

(2016) Irma Sánchez et al.   NATURE CELL BIOLOGY

Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused byTTLL5mutations

(2016) Xun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytic Control of Cellular Signaling at the Primary Cilium

(2016) Lotte B. Pedersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Posttranslational Modifications of Tubulin and Cilia

(2016) Dorota Wloga et al.   Cold Spring Harbor Perspectives in Biology

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition

(2016) Francesc R. Garcia-Gonzalo et al.   Cold Spring Harbor Perspectives in Biology

Cellular Mechanisms of Ciliary Length Control

(2016) Jacob Keeling et al.   Cells

Ciliary subcompartments: how are they established and what are their functions?

(2015) Jeongmi Lee et al.   BMB Reports

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

(2015) Gisela G Slaats et al.   JOURNAL OF MEDICAL GENETICS

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome

(2015) S. Paige Taylor et al.   Nature Communications

A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma

(2015) X Shi et al.   Oncogenesis

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Kif7 keeps cilia tips in shape

(2014) Lotte B. Pedersen et al.   NATURE CELL BIOLOGY

How do cilia organize signalling cascades?

(2014) M. V. Nachury   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lack of Dopaminergic Inputs Elongates the Primary Cilia of Striatal Neurons

(2014) Ko Miyoshi et al.   PLoS One

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

The nphp-2 and arl-13 Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in C. elegans

(2014) Simon R. F. Warburton-Pitt et al.   PLoS Genetics

A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

(2014) David B Doroquez et al.   eLife

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

(2013) Amy L. Cherry et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Cilium Secretes Bioactive Ectosomes

(2013) Christopher R. Wood et al.   CURRENT BIOLOGY

Assembling a primary cilium

(2013) Sehyun Kim et al.   CURRENT OPINION IN CELL BIOLOGY

The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity

(2013) Amanda C. Leightner et al.   HUMAN MOLECULAR GENETICS

Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length

(2013) R. Ghossoub et al.   JOURNAL OF CELL SCIENCE

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

(2012) A. K. T. Wann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

(2012) Z. J. Li et al.   DEVELOPMENT

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

Context-Dependent Regulation of Wnt Signaling through the Primary Cilium

(2012) E. C. Oh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Analysis of human samples reveals impaired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome

(2012) A. Aguilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of human septin interactions

(2011) Kirstin Sandrock et al.   BIOLOGICAL CHEMISTRY

The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans

(2011) Robert O'Hagan et al.   CURRENT BIOLOGY

Soluble levels of cytosolic tubulin regulate ciliary length control

(2011) Neeraj Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments

(2011) Limin Hao et al.   NATURE CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

(2010) Tatiana Y. Besschetnova et al.   CURRENT BIOLOGY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution

(2010) Q. Hu et al.   SCIENCE

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3

(2009) Rachaneekorn Tammachote et al.   HUMAN MOLECULAR GENETICS

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development

(2008) Christine Insinna et al.   DEVELOPMENTAL BIOLOGY

Sensory Signaling-Dependent Remodeling of Olfactory Cilia Architecture in C. elegans

(2008) Saikat Mukhopadhyay et al.   DEVELOPMENTAL CELL