The metabolism of the synthetic cannabinoids ADB‐BUTINACA and ADB‐4en‐PINACA and their detection in forensic toxicology casework and infused papers seized in prisons

A transnational perspective on the evolution of the synthetic cannabinoid receptor agonists market: Comparing prison and general populations

(2021) Caitlyn Norman et al.   Drug Testing and Analysis

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB 1 receptor activation assays—Part II: Structure activity relationship assessment via a β‐arrestin recruitment assay

(2021) Katharina Elisabeth Grafinger et al.   Drug Testing and Analysis

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB 1 receptor activation assays: Part I—Synthesis, analytical characterization, and binding affinity for human CB 1 receptors

(2021) Edward Pike et al.   Drug Testing and Analysis

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA and MMB‐4CN‐BUTINACA using a combination of binding and different CB1 receptor activation assays PART III: The G protein pathway and critical comparison of different assays

(2021) Katharina Elisabeth Grafinger et al.   Drug Testing and Analysis

Modulation of human T-type calcium channels by synthetic cannabinoid receptor agonists in vitro

(2021) Chris Bladen et al.   NEUROPHARMACOLOGY

Urinary Metabolite Biomarkers for the Detection of Synthetic Cannabinoid ADB-BUTINACA Abuse

(2021) Chi Hon Sia et al.   CLINICAL CHEMISTRY

Synthetic cannabinoid receptor agonists profile in infused papers seized in Brazilian prisons

(2021) Taís B. Rodrigues et al.   Forensic Toxicology

Synthesis, characterisation, detection and quantification of a novel hexyl-substituted synthetic cannabinoid receptor agonist: (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA)

(2021) Nicolas Gilbert et al.   Forensic Chemistry

The impact of the 2016 Psychoactive Substances Act on synthetic cannabinoid use within the homeless population: Markets, content and user harms

(2021) Rob Ralphs et al.   INTERNATIONAL JOURNAL OF DRUG POLICY

Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market

(2020) Caitlyn Norman et al.   Drug Testing and Analysis

Metabolism of MMB022 and identification of dihydrodiol formation in vitro using synthesized standards

(2020) Shimpei Watanabe et al.   Drug Testing and Analysis

Large‐scale evaluation of ion mobility spectrometry for the rapid detection of synthetic cannabinoid receptor agonists in infused papers in prisons

(2020) Caitlyn Norman et al.   Drug Testing and Analysis

The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent‐4en and but‐3en analogues including MDMB‐4en‐PINACA

(2020) Alex J. Krotulski et al.   Drug Testing and Analysis

In vitro characterization of new psychoactive substances at the µ-opioid, CB1, 5HT1A, and 5-HT2A receptors—On-target receptor potency and efficacy, and off-target effects

(2020) Anna Åstrand et al.   FORENSIC SCIENCE INTERNATIONAL

Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling

(2020) Kenneth B. Walsh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA

(2020) Annelies Cannaert et al.   ACS Chemical Neuroscience

Shape matters: The application of activity‐based in vitro bioassays and chiral profiling to the pharmacological evaluation of synthetic cannabinoid receptor agonists in drug‐infused papers seized in prisons

(2020) Lysbeth H. Antonides et al.   Drug Testing and Analysis

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites

(2019) Xingxing Diao et al.   Frontiers in Chemistry

CUMYL-4CN-BINACA Is an Efficacious and Potent Pro-Convulsant Synthetic Cannabinoid Receptor Agonist

(2019) Richard C. Kevin et al.   Frontiers in Pharmacology

Enantiospecific Synthesis, Chiral Separation, and Biological Activity of Four Indazole-3-Carboxamide-Type Synthetic Cannabinoid Receptor Agonists and Their Detection in Seized Drug Samples

(2019) Lysbeth H. Antonides et al.   Frontiers in Chemistry

Biotransformation of the New Synthetic Cannabinoid with an Alkene, MDMB-4en-PINACA, by Human Hepatocytes, Human Liver Microsomes, and Human Urine and Blood

(2019) Shimpei Watanabe et al.   AAPS Journal

Evaluation of carboxamide-type synthetic cannabinoids as CB1/CB2 receptor agonists: difference between the enantiomers

(2017) Takahiro Doi et al.   Forensic Toxicology

New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine

(2017) Lilian H.J. Richter et al.   TOXICOLOGY LETTERS

Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites

(2016) X Diao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes

(2015) X. Diao et al.   CLINICAL CHEMISTRY

Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances

(2015) Zhenhua Qian et al.   Forensic Toxicology

Identification of AB-FUBINACA metabolites in human hepatocytes and urine using high-resolution mass spectrometry

(2015) Marisol S. Castaneto et al.   Forensic Toxicology

Liquid chromatography/time-of-flight mass spectrometry analysis of postmortem blood samples for targeted toxicological screening

(2013) Markus Roman et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY