Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs
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Title
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs
Authors
Keywords
Lipid nanoparticles, Ionizable lipid, LNP, mRNA vaccine, COVID-19, Patisiran, Tozinameran, Elasomeran, COVID-19 vaccine moderna, SARS-CoV-2
Journal
Drug Metabolism and Pharmacokinetics
Volume 41, Issue -, Pages 100424
Publisher
Elsevier BV
Online
2021-10-12
DOI
10.1016/j.dmpk.2021.100424
References
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Note: Only part of the references are listed.- Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach
- (2021) Takeshi Terada et al. LANGMUIR
- mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach
- (2021) Aleena Banerji et al. Journal of Allergy and Clinical Immunology-In Practice
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- (2021) Michael D. Buschmann et al. Vaccines
- Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
- (2021) Tom T. Shimabukuro et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
- (2021) Linde Schoenmaker et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
- (2021) Ruklanthi de Alwis et al. MOLECULAR THERAPY
- mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents
- (2021) Susanne Rauch et al. npj Vaccines
- CureVac COVID vaccine let-down spotlights mRNA design challenges
- (2021) Elie Dolgin NATURE
- The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA
- (2021) Pratikkumar Patel et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The promise of mRNA vaccines: a biotech and industrial perspective
- (2020) Nicholas A. C. Jackson et al. npj Vaccines
- Lipid nanoparticles for nucleic acid delivery: Current perspectives
- (2020) Eleni Samaridou et al. ADVANCED DRUG DELIVERY REVIEWS
- Lipid nanoparticle technology for therapeutic gene regulation in the liver
- (2020) Dominik Witzigmann et al. ADVANCED DRUG DELIVERY REVIEWS
- Recent advances in siRNA delivery mediated by lipid-based nanoparticles
- (2020) Sei Yonezawa et al. ADVANCED DRUG DELIVERY REVIEWS
- Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals
- (2020) Gergely Tibor Kozma et al. ADVANCED DRUG DELIVERY REVIEWS
- A Thermostable mRNA Vaccine against COVID-19
- (2020) Na-Na Zhang et al. CELL
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
- (2020) Dorottya Laczkó et al. IMMUNITY
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
- (2020) Paul F. McKay et al. Nature Communications
- Impact of mRNA chemistry and manufacturing process on innate immune activation
- (2020) Jennifer Nelson et al. Science Advances
- PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production
- (2020) Takuya Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti-PEG IgE in anaphylaxis associated with polyethylene glycol
- (2020) Zhao-Hua Zhou et al. Journal of Allergy and Clinical Immunology-In Practice
- Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
- (2019) Khalid A. Hajj et al. Small
- Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles
- (2019) Takeshi Kuboyama et al. ACS Medicinal Chemistry Letters
- Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
- (2019) Kimberly J. Hassett et al. Molecular Therapy-Nucleic Acids
- Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure‐Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin‐Mediated (hATTR) Amyloidosis
- (2019) Xiaoping Zhang et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
- (2019) Marco Maugeri et al. Nature Communications
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- Roadmap and strategy for overcoming infusion reactions to nanomedicines
- (2018) Janos Szebeni et al. Nature Nanotechnology
- Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates
- (2017) Yuta Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
- (2017) Frank Liang et al. MOLECULAR THERAPY
- N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
- (2017) Yuri V. Svitkin et al. NUCLEIC ACIDS RESEARCH
- Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
- (2016) Rebecca Ball et al. International Journal of Nanomedicine
- Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid
- (2016) Yuta Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo
- (2015) Y. Suzuki et al. JOURNAL OF CONTROLLED RELEASE
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- (2015) Anders Wittrup et al. NATURE BIOTECHNOLOGY
- Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery
- (2015) Hidetaka Akita et al. ACS Biomaterials-Science & Engineering
- Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery
- (2015) Hidetaka Akita et al. ACS Biomaterials Science & Engineering
- Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
- (2014) Y. Dong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
- (2013) Barbara L Mui et al. Molecular Therapy-Nucleic Acids
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics
- (2012) Marian E Gindy et al. Expert Opinion on Drug Delivery
- The Chemical Synthesis of DNA/RNA: Our Gift to Science
- (2012) Marvin H. Caruthers JOURNAL OF BIOLOGICAL CHEMISTRY
- A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
- (2012) Yusuke Sato et al. JOURNAL OF CONTROLLED RELEASE
- Developing mRNA-vaccine technologies
- (2012) Thomas Schlake et al. RNA Biology
- Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
- (2011) Genc Basha et al. MOLECULAR THERAPY
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Lipid-like materials for low-dose, in vivo gene silencing
- (2010) K. T. Love et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
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