Adenovirus vector-based vaccine for infectious diseases

Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

(2021) Koji Onomoto et al.   Cellular & Molecular Immunology

A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study of Ad26.ZIKV.001, an Ad26-Vectored Anti–Zika Virus Vaccine

(2021) Nadine C. Salisch et al.   ANNALS OF INTERNAL MEDICINE

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

MAIT cell activation augments adenovirus vector vaccine immunogenicity

(2021) Nicholas M. Provine et al.   SCIENCE

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

(2021) Katherine R W Emary et al.   LANCET

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

(2021) Andreas Greinacher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

(2021) Coraline Chéneau et al.   Frontiers in Immunology

Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines

(2021) Jimin Hwang et al.   JOURNAL OF AUTOIMMUNITY

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

(2021) Traci L. Bricker et al.   Cell Reports

A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

(2021) Anne Louise Tølbøll Sørensen et al.   Blood Advances

Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles

(2021) Yoshihiko Kakiuchi et al.   MOLECULAR THERAPY

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Feng-Cai Zhu et al.   LANCET

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

(2020) Noe B. Mercado et al.   NATURE

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

(2020) Denis Y Logunov et al.   LANCET

The Brighton Collaboration standardized template for collection of key information for risk/benefit assessment of a Modified Vaccinia Ankara (MVA) vaccine platform

(2020) Ariane Volkmann et al.   VACCINE

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study

(2020) Lindsey R Baden et al.   Lancet HIV

Extracellular Vesicles-Mimetic Encapsulation Improves Oncolytic Viro-Immunotherapy in Tumors With Low Coxsackie and Adenovirus Receptor

(2020) Yonghui Zhang et al.   Frontiers in Bioengineering and Biotechnology

A rapid strategy for constructing novel simian adenovirus vectors with high viral titer and expressing highly antigenic proteins applicable for vaccine development

(2019) Shengxue Luo et al.   VIRUS RESEARCH

Human adenovirus type 26 uses sialic acid–bearing glycans as a primary cell entry receptor

(2019) Alexander T. Baker et al.   Science Advances

Innate immunity to adenovirus: lessons from mice

(2019) Svetlana Atasheva et al.   FEBS LETTERS

Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models

(2018) Qiang Guo et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage

(2018) Kun Xu et al.   JOURNAL OF VIROLOGY

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway

(2018) Aleksandra Anchim et al.   Frontiers in Immunology

Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults

(2018) L. Coughlan et al.   EBioMedicine

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor

(2017) Fengliang Liu et al.   JOURNAL OF IMMUNOLOGY

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

(2017) Masahisa Hemmi et al.   Frontiers in Immunology

Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy

(2016) Li Ran et al.   BIOMATERIALS

Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity

(2016) Daniela Anghelina et al.   JOURNAL OF VIROLOGY

Anticipating the international spread of Zika virus from Brazil

(2016) Isaac I Bogoch et al.   LANCET

Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling

(2015) Kylie M. Quinn et al.   JOURNAL OF CLINICAL INVESTIGATION

Human mastadenovirus type 70: a novel, multiple recombinant species D mastadenovirus isolated from diarrhoeal faeces of a haematopoietic stem cell transplantation recipient

(2015) Elias Hage et al.   JOURNAL OF GENERAL VIROLOGY

Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial

(2015) Feng-Cai Zhu et al.   LANCET

Ebola from emergence to epidemic: the virus and the disease, global preparedness and perspectives

(2015) Kuldeep Dhama et al.   Journal of Infection in Developing Countries

Trafficking of Antigen-Specific CD8+ T Lymphocytes to Mucosal Surfaces following Intramuscular Vaccination

(2014) D. R. Kaufman et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo

(2014) D. M. Appledorn et al.   JOURNAL OF IMMUNOLOGY

Induction of HIV-1–Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans

(2014) Lindsey R. Baden et al.   JOURNAL OF INFECTIOUS DISEASES

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

(2014) Daphne A Stanley et al.   NATURE MEDICINE

Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial

(2014) Emma-Jo Hayton et al.   PLoS One

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

(2012) Masaki Shoji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X

(2012) Hayato Matsui et al.   BIOMATERIALS

Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route

(2012) L. Jean Patterson et al.   Clinical and Vaccine Immunology

A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity

(2012) Matthew D. J. Dicks et al.   PLoS One

Adenovirus Virus-Associated RNAs Induce Type I Interferon Expression through a RIG-I-Mediated Pathway

(2011) T. Minamitani et al.   JOURNAL OF VIROLOGY

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction

(2010) Emi Suzuki-Kouyama et al.   BIOMATERIALS

Creation of a panel of vectors based on ape adenovirus isolates

(2010) Soumitra Roy et al.   JOURNAL OF GENE MEDICINE

Multiple Innate Immune Pathways Contribute to the Immunogenicity of Recombinant Adenovirus Vaccine Vectors

(2010) E. G. Rhee et al.   JOURNAL OF VIROLOGY

Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8+ T Lymphocytes

(2010) D. R. Kaufman et al.   JOURNAL OF VIROLOGY

Adenovirus-Based Vaccines: Comparison of Vectors from Three Species ofAdenoviridae

(2010) H. Chen et al.   JOURNAL OF VIROLOGY

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of type I interferon by adenovirus-encoded small RNAs

(2010) T. Yamaguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

(2010) Glenda Gray et al.   Current Opinion in HIV and AIDS

Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization

(2009) C. Cheng et al.   JOURNAL OF VIROLOGY

Protective Efficacy of a Single Immunization of a Chimeric Adenovirus Vector-Based Vaccine against Simian Immunodeficiency Virus Challenge in Rhesus Monkeys

(2009) D. H. Barouch et al.   JOURNAL OF VIROLOGY

Anionic Liposomes Increase the Efficiency of Adenovirus-Mediated Gene Transfer to Coxsackie-Adenovirus Receptor Deficient Cells

(2009) Zhirong Zhong et al.   MOLECULAR PHARMACEUTICS

Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge

(2009) Ki Seok Park et al.   VIROLOGY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Downregulation of CD46 During Muscle Differentiation: Implications for Gene Transfer to Human Skeletal Muscle Using Group B Adenoviruses

(2007) Nancy Larochelle et al.   HUMAN GENE THERAPY