Article
Oncology
Piao Li, Lingling Li, Zhou Li, Shennan Wang, Ruichao Li, Weiheng Zhao, Yanqi Feng, Shanshan Huang, Lu Li, Hong Qiu, Shu Xia
Summary: The study found that the high expression of ANXA1 in bladder cancer is closely associated with disease progression and prognosis. Silencing ANXA1 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of bladder cancer cells, and suppresses the growth of xenografted bladder tumors. ANXA1 promotes the proliferation and migration of bladder cancer by activating the EGFR signaling pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Qi Li, Mo Yan, Chunhui Wang, Kaibin Wang, Guochang Bao
Summary: CKAP2L is overexpressed in prostate cancer and is associated with higher Gleason grade and poor clinical outcomes. Silencing CKAP2L inhibits cell proliferation, impairs monolayer formation, and inhibits cell invasion. CKAP2L is a direct target of miR-326, which has a carcinostatic effect by binding to the 3' untranslated regions (3'UTRs) of CKAP2L mRNA. Deletion of CKAP2L reduces the expression of genes involved in the mitotic cell cycle and chromosome segregation.
Article
Pathology
Jinhui Yang, Fuming Qi, Bo Tan, Guangcheng Dai, Rongxin Chen, Wenjie Wan, Bo Cheng, Boxin Xue
Summary: In this study, circSPECC1 was found to be significantly up-regulated in bladder cancer tissues and cell lines. Increased expression of circSPECC1 was associated with poor prognosis in bladder cancer. Knockdown of circSPECC1 was shown to impair the proliferation and migration of bladder cancer cells. Mechanistically, circSPECC1 was found to sponge miR-136-5p and promote the expression of GNAS, which reversed the effects of circSPECC1 suppression on cell proliferation and migration. This study suggested that circSPECC1 contributes to the growth and metastasis of bladder cancer and has potential as a non-invasive biomarker for diagnosis and therapeutic target for treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Na Luo, Shiqin Liu, Xin Li, Yu Hu, Kejing Zhang
Summary: The study revealed that circHIPK3 promotes breast cancer growth and metastasis by sponging miR-326. Overexpression of circHIPK3 enhanced proliferation, migration, invasion, apoptosis resistance, and tumor growth, while these effects were partially reversed by miR-326 overexpression. This suggests a novel therapeutic target for breast cancer treatment.
Article
Oncology
Zhaocun Zhang, Haifeng Zhao, Guanwen Zhou, Ruoyan Han, Zhuang Sun, Minglei Zhong, Xianzhou Jiang
Summary: This study reveals that circ_0002623 is upregulated in bladder cancer, and it competitively binds with miR-1276 to increase the expression of SMAD2, promoting the proliferation, migration, and cell cycle progression of bladder cancer cells. These findings contribute to a better understanding of the molecular mechanisms underlying the progression of bladder cancer.
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Dan Yang, Yinxian Chen, Zhen Ning Tony He, Yichen Wang, Chenghui Ke, Yi Luo, Sun Wang, Qichao Ma, Mengjie Chen, Qing Yang, Ziming Zhang
Summary: This study found that the immunosuppressive enzyme IDO1 is highly expressed in osteosarcoma tissues and is related to immune tolerance and progression of the tumor. Experimental results showed that IDO1 significantly affects exosome-derived miRNA subsets from osteosarcoma cells. The key miRNA hsa-miR-23a-3p involved in the progression of osteosarcoma was identified. Targeting IDO1-mediated hsa-miR-23a-3p could be a potential therapeutic strategy for osteosarcoma treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Xuanyu Chen, Song Chen
Summary: The study aimed to explore the effects of LINC00649 on the proliferation, migration, and invasion of bladder cancer and identified a potential mechanism involving the regulation of the miR-15a-5p/HMGA1 axis. High expression of LINC00649 was associated with poor overall survival in bladder cancer patients, while upregulation of LINC00649 enhanced the malignant progression of bladder cancer cells in vitro. This suggests that LINC00649 may serve as a biomarker and therapeutic target for bladder cancer.
Article
Oncology
Xiaoting Zhang, Xiaofeng Li, Xian Fu, Mengli Yu, Guicheng Qin, Guihong Chen, Chenchen Huang
Summary: Bladder cancer (BCa) is the most common malignant tumor of the urinary system. Circular RNA TAF4B (circTAF4B) was identified as significantly upregulated in BCa and correlated with poor prognosis. Downregulation of circTAF4B inhibited growth, metastasis, and the EMT process in BCa cells by sponging miR-1298-5p to facilitate the expression of transforming growth factor A (TGFA). CircTAF4B may be a diagnostic and therapeutic target for BCa.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kun Fang, Zheng-Jie Xu, Su-Xiao Jiang, De-Sheng Tang, Chang-Sheng Yan, You-Yuan Deng, Fu-Ying Zhao
Summary: Breast cancer is the second most common cancer in women globally. This study identified lncRNA FGD5-AS1 as a key player in breast cancer progression, affecting cell proliferation, migration, and invasion through the miR-195-5p/NUAK2 axis and impacting glycolysis. The findings suggest that FGD5-AS1 could be a potential target for intervention in breast cancer patients.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Jianzhuang Gong, Chenxu Du, Nai Sun, Xingguo Xiao, Huili Wu
Summary: The study revealed that hsa_circ_0005397 was up-regulated in hepatocellular carcinoma (HCC) tissues and cells, while miR-326 was down-regulated. Silencing of hsa_circ_0005397 inhibited cell proliferation and metastasis, and promoted apoptosis. The findings suggest that hsa_circ_0005397 promotes HCC progression by regulating the miR-326/PDK2 axis, providing a potential circRNA-targeted therapy for HCC.
JOURNAL OF GENE MEDICINE
(2021)
Article
Cell Biology
Ti-Chun Chan, Chung-Hsi Hsing, Yow-Ling Shiue, Steven K. Huang, Kun-Lin Hsieh, Yu-Hsuan Kuo, Chien-Feng Li
Summary: This study uncovers the biological significance of the CEBPD/hsa-miR-429/VEGFA axis in angiogenesis and tumor growth in urothelial carcinoma (UC). By inhibiting hsa-miR-429, CEBPD stabilizes the expression of VEGFA, leading to the progression of UC.
Article
Cell Biology
Ying Liu, Lei Li, Xiang Song
Summary: This study reveals the mechanism by which circPVT1 in lung cancer-derived exosomes promotes proliferation, invasion, and migration of lung cancer cells. It demonstrates that circPVT1 regulates macrophage polarization through the miR-124-3p/EZH2 axis, leading to enhanced biological functions of lung cancer cells.
Article
Oncology
Yingying Huang, Xiaoxiao Du, Xiangliu Chen, Chuanzhi Chen, Haiyong Wang, Yan Yang, Lisong Teng
Summary: The study found that highly expressed miR-301a-5p is associated with the aggressiveness of gastric cancer, promoting malignant phenotype by targeting SCIN. Further investigation revealed that alterations in miR-301a-5p levels could impact the epithelial-mesenchymal transition (EMT) process in gastric cancer cells.
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Oncology
Tangwu Zhong, Chuanke Zhao, Shuntao Wang, Deshuang Tao, Shuxia Ma, Chengchao Shou
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Article
Oncology
Zunxian Wang, Bo Wei, Shuxia Ma
Summary: This study identifies a coherent feed-forward loop involving EGR1, LINC00839/miR-142, and SOX5 that modulates the migration, invasion, and Gemcitabine resistance of bladder cancer.
CANCER BIOLOGY & THERAPY
(2023)