Terpyridine copper(ii) complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells

Mustards-Derived Terpyridine–Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination

(2021) Muneebah Adams et al.   INORGANIC CHEMISTRY

Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper(II) complexes containing gluconate

(2021) Dai-Hong Cai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents

(2021) Yuxia Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences

(2021) Ana Zamora et al.   INORGANIC CHEMISTRY

Tracking cell apoptosis based on mitochondria and cell membrane imaging

(2021) Chang Zhao et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

(2021) Hudie Wei et al.   Nature Communications

Xiaokang Liuwei Dihuang decoction ameliorates the immune infertility of male rats induced by lipopolysaccharide through regulating the levels of sex hormones, reactive oxygen species, pro-apoptotic and immune factors

(2021) Xiaoyong Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway

(2021) Anhui Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway

(2021) Weiqi Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Anticancer activity of 4′-phenyl-2,2′:6′,2″-terpyridines – behind the metal complexation

(2020) Katarzyna Malarz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: Unravelling an unexplored pharmacological target

(2020) Mauro Carcelli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

In vitro and in vivo effects of flubendiamide and copper on cyto-genotoxicity, oxidative stress and spleen histology of rats and its modulation by resveratrol, catechin, curcumin and α-tocopherol

(2020) Rajesh Mandil et al.   BMC Pharmacology & Toxicology

Platinum(II) Terpyridine Anticancer Complexes Possessing Multiple Mode of DNA Interaction and EGFR Inhibiting Activity

(2020) Chaoyang Li et al.   Frontiers in Chemistry

Influence of DMβCD on the Interaction of Copper(II) Complex of 6-Hydroxychromone-3-carbaldehyde-3-hydroxybenzoylhydrazine with ctDNA

(2020) Horacio Gómez-Machuca et al.   ACS Omega

Targeting apoptotic caspases in cancer

(2020) Ashley Boice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

(2020) Xing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Targeting of Probes and Therapeutics to the Powerhouse of the Cell

(2020) Cindy Ma et al.   BIOCONJUGATE CHEMISTRY

Dicopper(II) Complexes of p-Cresol-2,6-Bis(dpa) Amide-Tether Ligands: Large Enhancement of Oxidative DNA Cleavage, Cytotoxicity, and Mechanistic Insight by Intracellular Visualization

(2020) Yuki Kadoya et al.   INORGANIC CHEMISTRY

Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases

(2020) Pengfei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action

(2020) Hong Yin et al.   JOURNAL OF NATURAL PRODUCTS

Highly cytotoxic copper(II) terpyridine complexes as anticancer drug candidates

(2020) Johannes Karges et al.   INORGANICA CHIMICA ACTA

Exposure to copper induces mitochondria-mediated apoptosis by inhibiting mitophagy and the PINK1/parkin pathway in chicken (Gallus gallus) livers

(2020) Fan Yang et al.   JOURNAL OF HAZARDOUS MATERIALS

On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway

(2019) Diletta Ciardo et al.   Genes

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death

(2019) Lorena Polloni et al.   BIOMEDICINE & PHARMACOTHERAPY

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

(2019) Johannes Karges et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

(2019) Jiangjuan Shao et al.   Cell Communication and Signaling

Crystal structure, DNA interactions, antioxidant and antitumor activity of thermally stable Cu(II), Ni(II) and Co(III) complexes of an N,O donor Schiff base ligand

(2019) Kadtala Venkateswarlu et al.   POLYHEDRON

Zinc oxide nanoparticles synthesized from Cardiospermum halicacabum and its anticancer activity in human melanoma cells (A375) through the modulation of apoptosis pathway

(2019) Xi Duan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Mitochondria-targeting Anticancer Metal Complexes

(2018) Andrea Erxleben   CURRENT MEDICINAL CHEMISTRY

Mixed-ligand Cu(II) hydrazone complexes designed to enhance anticancer activity

(2018) QingYou Mo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

(2018) Ke-Bin Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

(2018) Nandita Dasgupta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells

(2018) Bing Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis of new sarsasapogenin derivatives with cytotoxicity and apoptosis-inducing activities in human breast cancer MCF-7 cells

(2017) Wenbao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current and upcoming mitochondrial targets for cancer therapy

(2017) Hyoung Kyu Kim et al.   SEMINARS IN CANCER BIOLOGY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Synthesis, crystal structure and magnetic properties of a new copper oxo-antimony sulphate CuSb6O8(SO4)2

(2016) Iwan Zimmermann et al.   DALTON TRANSACTIONS

Preparation of 4-([2,2′:6′,2″-terpyridin]-4′-yl)-N,N-diethylaniline Ni II and Pt II complexes and exploration of their in vitro cytotoxic activities

(2016) Hua-Hong Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Copper(II) Complexes of Phenanthroline and Histidine Containing Ligands: Synthesis, Characterization and Evaluation of their DNA Cleavage and Cytotoxic Activity

(2016) Sílvia M. G. Leite et al.   INORGANIC CHEMISTRY

Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP + -linked-polyhydroxybenzoates

(2016) Cristian Sandoval-Acuña et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

(2015) Creina Slator et al.   ACS Chemical Biology

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury

(2015) L Gomez et al.   CELL DEATH AND DIFFERENTIATION

Intercalation processes of copper complexes in DNA

(2015) R. Galindo-Murillo et al.   NUCLEIC ACIDS RESEARCH

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

New Water-Soluble Ruthenium(II) Terpyridine Complexes for Anticancer Activity: Synthesis, Characterization, Activation Kinetics, and Interaction with Guanine Derivatives

(2014) Ana Rilak et al.   INORGANIC CHEMISTRY

Synthesis, DNA interaction and anticancer activity of copper(II) complexes with 4′-phenyl-2,2′:6′,2″-terpyridine derivatives

(2014) Jie-Wen Liang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery

(2014) Yao-Rong Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action

(2014) Wen Zhou et al.   Chemical Science

Exploration of the medical periodic table: towards new targets

(2013) Nicolas P. E. Barry et al.   CHEMICAL COMMUNICATIONS

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Antitumor trans-N-Heterocyclic Carbene–Amine–Pt(II) Complexes: Synthesis of Dinuclear Species and Exploratory Investigations of DNA Binding and Cytotoxicity Mechanisms

(2013) Mélanie Chtchigrovsky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes

(2012) Isolda Romero-Canelón et al.   Metallomics

A kinetic investigation into the rate of chloride substitution from chloro terpyridine platinum(II) and analogous complexes by a series of azole nucleophiles

(2011) Desigan Reddy et al.   TRANSITION METAL CHEMISTRY

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY