Order through disorder: The role of intrinsically disordered regions in transcription factor binding specificity

Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics

(2021) Liang Ma et al.   MOLECULAR CELL

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

(2021) David A. Garcia et al.   MOLECULAR CELL

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

(2021) Prashant Rawat et al.   MOLECULAR CELL

Unblending of Transcriptional Condensates in Human Repeat Expansion Disease

(2020) Shaon Basu et al.   CELL

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

(2020) Sagie Brodsky et al.   MOLECULAR CELL

De novo engineering of intracellular condensates using artificial disordered proteins

(2020) Michael Dzuricky et al.   Nature Chemistry

Nucleated transcriptional condensates amplify gene expression

(2020) Ming-Tzo Wei et al.   NATURE CELL BIOLOGY

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin

(2020) Yuanting Wang et al.   IMMUNITY

Mechanisms of Interplay between Transcription Factors and the 3D Genome

(2019) Seungsoo Kim et al.   MOLECULAR CELL

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

(2019) Yang Eric Guo et al.   NATURE

Switching Condensates: The CTD Code Goes Liquid

(2019) Bede Portz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites

(2018) Tim Zeiske et al.   Cell Reports

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

(2017) Richard B. Tunnicliffe et al.   NUCLEIC ACIDS RESEARCH

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Proteomic and bioinformatic analysis of a nuclear intrinsically disordered proteome

(2016) Bozena Skupien-Rabian et al.   Journal of Proteomics

Disordered nucleiome: Abundance of intrinsic disorder in the DNA- and RNA-binding proteins in 1121 species from Eukaryota, Bacteria and Archaea

(2016) Chen Wang et al.   PROTEOMICS

To Be Specific or Not: The Critical Relationship Between Hox And TALE Proteins

(2016) Samir Merabet et al.   TRENDS IN GENETICS

Deconvolving the Recognition of DNA Shape from Sequence

(2015) Namiko Abe et al.   CELL

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Genome-scale prediction of proteins with long intrinsically disordered regions

(2013) Zhenling Peng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

DNA Minor Groove Sensing and Widening by the CCAAT-Binding Complex

(2012) Eva M. Huber et al.   STRUCTURE

Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins

(2011) Matthew Slattery et al.   CELL

Origins of Specificity in Protein-DNA Recognition

(2010) Remo Rohs et al.   Annual Review of Biochemistry

The role of DNA shape in protein–DNA recognition

(2009) Remo Rohs et al.   NATURE