Transcriptional and epigenetic control of early life cell fate decisions

H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos

(2021) Hailiang Mei et al.   NATURE GENETICS

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

(2021) Zhiyuan Chen et al.   NATURE GENETICS

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic lineage priming is driven via direct enhancer regulation by ERK

(2019) William B. Hamilton et al.   NATURE

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

(2019) Simone Tamburri et al.   MOLECULAR CELL

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

(2018) Courtney W. Hanna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

(2018) Courtney W. Hanna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development

(2018) Anna Hupalowska et al.   CELL

Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos

(2018) Jiaqiang Wang et al.   CELL

Genomic imprinting ofXistby maternal H3K27me3

(2017) Azusa Inoue et al.   GENES & DEVELOPMENT

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

(2017) Eszter Posfai et al.   eLife

Totipotency segregates between the sister blastomeres of two-cell stage mouse embryos

(2017) E. Casser et al.   Scientific Reports

Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo

(2016) Melanie D. White et al.   CELL

Lineage specification in the mouse preimplantation embryo

(2016) Claire Chazaud et al.   DEVELOPMENT

Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals

(2016) Hui Zheng et al.   MOLECULAR CELL

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

(2016) Xiaoyu Liu et al.   NATURE

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

(2016) Bingjie Zhang et al.   NATURE

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

(2016) John Arne Dahl et al.   NATURE

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

(2016) Rachel Amouroux et al.   NATURE CELL BIOLOGY

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

(2015) Douglas Vernimmen et al.   TRENDS IN GENETICS

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Programming and Inheritance of Parental DNA Methylomes in Mammals

(2014) Lu Wang et al.   CELL

Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes

(2014) Li Shen et al.   Cell Stem Cell

Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network

(2014) S. Bessonnard et al.   DEVELOPMENT

GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst

(2014) Nadine Schrode et al.   DEVELOPMENTAL CELL

Higher chromatin mobility supports totipotency and precedes pluripotency in vivo

(2014) A. Bo kovi  et al.   GENES & DEVELOPMENT

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

Erk Signaling Suppresses Embryonic Stem Cell Self-Renewal to Specify Endoderm

(2014) William B. Hamilton et al.   Cell Reports

HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst

(2014) Eryn Wicklow et al.   PLoS Genetics

FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst

(2013) Dayana Krawchuk et al.   DEVELOPMENTAL BIOLOGY

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

(2013) Yusuke Ohnishi et al.   NATURE CELL BIOLOGY

Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA

(2013) Anas Fadloun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Single-Cell Profiling of Epigenetic Modifiers Identifies PRDM14 as an Inducer of Cell Fate in the Mammalian Embryo

(2013) Adam Burton et al.   Cell Reports

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse

(2012) M. Kang et al.   DEVELOPMENT

Enhancers: emerging roles in cell fate specification

(2012) Chin-Tong Ong et al.   EMBO REPORTS

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

(2012) Toshinobu Nakamura et al.   NATURE

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development

(2011) Azusa Inoue et al.   CELL RESEARCH

Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo

(2011) J. B. Grabarek et al.   DEVELOPMENT

Primitive Endoderm Differentiates via a Three-Step Mechanism Involving Nanog and RTK Signaling

(2011) Stephen Frankenberg et al.   DEVELOPMENTAL CELL

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

(2011) Nicolas Plachta et al.   NATURE CELL BIOLOGY

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

(2011) Khursheed Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

(2011) A. Inoue et al.   SCIENCE

DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

(2010) Morito Sakaue et al.   CURRENT BIOLOGY

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2

(2010) A. Ralston et al.   DEVELOPMENT

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

(2010) O. Alder et al.   DEVELOPMENT

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

(2010) Y. Yamanaka et al.   DEVELOPMENT

Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

(2010) Guoji Guo et al.   DEVELOPMENTAL CELL

Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo

(2010) P. J. Rugg-Gunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

(2010) Claudia V. Andreu-Vieyra et al.   PLOS BIOLOGY

Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo

(2009) J. Nichols et al.   DEVELOPMENT

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Stochastic Processes during Mouse Blastocyst Patterning

(2008) Jens Erik Dietrich et al.   CELLS TISSUES ORGANS

Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst

(2008) B. Plusa et al.   DEVELOPMENT