Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface

Carbapenem use is driving the evolution of IMiPenemase (IMP)-1 variants

(2021) Zishuo Cheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Calculating metalation in cells reveals CobW acquires CoII for vitamin B12 biosynthesis while related proteins prefer ZnII

(2021) Tessa R. Young et al.   Nature Communications

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

(2021) Guillermo Bahr et al.   CHEMICAL REVIEWS

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

(2021) David Sychantha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe

(2021) Radhika Mehta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)

(2021) Melina M. B. Martínez et al.   mBio

Identification of Cisplatin and Palladium(II) Complexes as Potent Metallo-β-lactamases Inhibitors for Targeting Carbapenem-resistant Enterobacteriaceae (CRE)

(2020) Cheng Chen et al.   ACS Infectious Diseases

Evaluation of the EDTA-Modified Carbapenem Inactivation Method for Detecting Metallo-β-Lactamase-Producing Pseudomonas aeruginosa

(2020) Christian M. Gill et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Cephalosporin Prochelator Inhibits New Delhi Metallo-β-lactamase 1 without Removing Zinc

(2020) Abigail C. Jackson et al.   ACS Infectious Diseases

EDTA-modified carbapenem inactivation method (eCIM) for detecting IMP Metallo-β-lactamase–producing Pseudomonas aeruginosa: an assessment of increasing EDTA concentrations

(2020) Maxwell J. Lasko et al.   BMC MICROBIOLOGY

Variability in Zinc Concentration among Mueller-Hinton Broth Brands: Impact on Antimicrobial Susceptibility Testing of Metallo-β-lactamase-producing Enterobacteriaceae

(2020) Anastasia Bilinskaya et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Molecular Evolution of Transition Metal Bioavailability at the Host–Pathogen Interface

(2020) Giuliano T. Antelo et al.   TRENDS IN MICROBIOLOGY

Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin

(2020) Hongzhe Sun et al.   Nature Communications

Bacterial sensors define intracellular free energies for correct enzyme metalation

(2019) Deenah Osman et al.   Nature Chemical Biology

Nutrient Zinc at the Host–Pathogen Interface

(2019) Zachery R. Lonergan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rapid Fluorescent-Based Detection of New Delhi Metallo-β-Lactamases by Photo-Cross-Linking Using Conjugates of Azidonaphthalimide and Zinc(II)-Chelating Motifs

(2019) Monisha Singha et al.   ACS Omega

The Acinetobacter baumannii Znu system overcomes host-imposed nutrient zinc limitation

(2019) Laura E. Hesse et al.   INFECTION AND IMMUNITY

Development of carbapenem-based fluorogenic probes for the clinical screening of carbapenemase-producing bacteria

(2019) Juhyeon Kim et al.   BIOORGANIC CHEMISTRY

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

(2019) Zishuo Cheng et al.   mBio

Protein determinants of dissemination and host specificity of metallo-β-lactamases

(2019) Carolina López et al.   Nature Communications

Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods

(2019) Tomefa E Asempa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Transition Metal Sequestration by the Host-Defense Protein Calprotectin

(2018) Emily M. Zygiel et al.   Annual Review of Biochemistry

A Carbapenem-Based Off-On Fluorescent Probe for Specific Detection of Metallo-β-Lactamase Activities

(2018) Wuyu Mao et al.   CHEMBIOCHEM

A protein structure-guided covalent scaffold selectively targets the B1 and B2 subclass metallo-β-lactamases

(2018) Cheng Chen et al.   CHEMICAL COMMUNICATIONS

Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: effects of NDM mutations on stability, zinc affinity, mono-zinc activity

(2018) Zishuo Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceftazidime Is the Key Diversification and Selection Driver of VIM-Type Carbapenemases

(2018) Laura Martínez-García et al.   mBio

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

(2018) Runming Wang et al.   Nature Communications

The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition

(2017) Meiru Si et al.   Cell Reports

Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity

(2017) Alesha C. Stewart et al.   ACS Infectious Diseases

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7

(2017) Alexander Bergstrom et al.   ACS Infectious Diseases

Neisseria gonorrhoeae Evades Calprotectin-Mediated Nutritional Immunity and Survives Neutrophil Extracellular Traps by Production of TdfH

(2016) Sophonie Jean et al.   INFECTION AND IMMUNITY

Membrane anchoring stabilizes and favors secretion of New Delhi metallo-β-lactamase

(2016) Lisandro J González et al.   Nature Chemical Biology

Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation

(2015) Tomasz Kochańczyk et al.   Metallomics

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features

(2015) María-Rocío Meini et al.   MOLECULAR BIOLOGY AND EVOLUTION

Recent developments in copper and zinc homeostasis in bacterial pathogens

(2014) Joseph J Braymer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc

(2013) Andrea Ilari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Zinc Piracy as a Mechanism of Neisseria meningitidis for Evasion of Nutritional Immunity

(2013) Michiel Stork et al.   PLoS Pathogens

Metallo-β-lactamase structure and function

(2012) Timothy Palzkill   Annals of the New York Academy of Sciences

Mutagenesis of Zinc Ligand Residue Cys221 Reveals Plasticity in the IMP-1 Metallo-β-Lactamase Active Site

(2012) Lori B. Horton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metallo-β-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions

(2012) Javier M González et al.   Nature Chemical Biology

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

Efficacy of Calcium-EDTA as an Inhibitor for Metallo- -Lactamase in a Mouse Model of Pseudomonas aeruginosa Pneumonia

(2010) N. Aoki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence of Adaptability in Metal Coordination Geometry and Active-Site Loop Conformation among B1 Metallo-β-lactamases,

(2010) Javier M. González et al.   BIOCHEMISTRY

Secretion of GOB Metallo- -Lactamase in Escherichia coli Depends Strictly on the Cooperation between the Cytoplasmic DnaK Chaperone System and the Sec Machinery: Completion of Folding and Zn(II) Ion Acquisition Occur in the Bacterial Periplasm

(2009) J. Moran-Barrio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY