Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

5‑Nitro‑2‑(3‑phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway

(2021) Lingzhi Niu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Therapeutic effect of secretome from TNF-α stimulated mesenchymal stem cells in an experimental model of corneal limbal stem cell deficiency

(2021) Guo-Hu Di et al.   International Journal of Ophthalmology

Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

(2021) Yuanyuan Tu et al.   BIOMEDICINE & PHARMACOTHERAPY

A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation, characterization, ex-vivo permeation, in-vitro ocular toxicity, and stability study

(2021) Nikita Mehra et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye

(2021) Bowen Wang et al.   EXPERIMENTAL EYE RESEARCH

AQP5 regulates vimentin expression via miR-124–3p.1 to protect lens transparency

(2021) Suzhen Tang et al.   EXPERIMENTAL EYE RESEARCH

Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure

(2020) Fan Hong et al.   Cells

Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc

(2020) Fan Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy

(2020) Changjiang Gu et al.   Oxidative Medicine and Cellular Longevity

Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery

(2020) Xuefei Li et al.   Drug Delivery and Translational Research

New resveratrol micelle formulation for ocular delivery: characterization and in vitro/in vivo evaluation

(2020) Mengshuang Li et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye

(2020) Chaoqun Yu et al.   Scientific Reports

Expression Profiles of CircRNA and mRNA in Lacrimal Glands of AQP5–/– Mice With Primary Dry Eye

(2020) Yaning Liu et al.   Frontiers in Physiology

Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro

(2020) Zhao Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

(2020) Víctor Farré-Alins et al.   Antioxidants

Effect of melatonin and its analogues in the tear secretion.

(2019) FRANCISCO JAVIER NAVARRO GIL et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Patient-reported outcomes of autologous serum tears for the treatment of dry eye disease in a large cohort

(2019) M. Kreimei et al.   Ocular Surface

Potential Albumin-Based Antioxidant Nanoformulations for Ocular Protection against Oxidative Stress

(2019) Kim et al.   Pharmaceutics

Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice

(2019) Jianhua Luo et al.   LIFE SCIENCES

Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability

(2018) Angela Varela-Garcia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye

(2017) Wei Chi et al.   JOURNAL OF AUTOIMMUNITY

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Keratitis in Dry Eye Disease and Topical Ciclosporin A

(2017) Andrea Leonardi et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

TFOS DEWS II pathophysiology report

(2017) Anthony J. Bron et al.   Ocular Surface

TFOS DEWS II pain and sensation report

(2017) Carlos Belmonte et al.   Ocular Surface

TFOS DEWS II Epidemiology Report

(2017) Fiona Stapleton et al.   Ocular Surface

TFOS DEWS II Definition and Classification Report

(2017) Jennifer P. Craig et al.   Ocular Surface

Nano-sized Soluplus® polymeric micelles enhance the induction of tetanus toxin neutralising antibody response following transcutaneous immunisation with tetanus toxoid

(2017) Manolya Saydam et al.   VACCINE

Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients

(2015) Qinxiang Zheng et al.   EXPERIMENTAL EYE RESEARCH

Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation

(2014) P H Sande et al.   BRITISH JOURNAL OF PHARMACOLOGY

A New Mouse Model of Dry Eye Disease

(2012) Yuichi Uchino et al.   CORNEA

Melatonin protects against oxidative stress in granular corneal dystrophy type 2 corneal fibroblasts by mechanisms that involve membrane melatonin receptors

(2011) Seung-Il Choi et al.   JOURNAL OF PINEAL RESEARCH

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH