The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains

(2020) Brendan T Keenan et al.   SLEEP

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Whole Genome Sequencing and Progress Towards Full Inbreeding of the Mouse Collaborative Cross Population

(2019) John R. Shorter et al.   G3-Genes Genomes Genetics

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

(2019) Hassan S. Dashti et al.   Nature Communications

Newly identified sleep–wake and circadian circuits as potential therapeutic targets

(2019) Anne Venner et al.   SLEEP

A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila

(2019) Hirofumi Toda et al.   SCIENCE

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

(2019) Philip R. Jansen et al.   NATURE GENETICS

Reference Trait Analysis Reveals Correlations Between Gene Expression and Quantitative Traits in Disjoint Samples

(2019) Daniel A. Skelly et al.   GENETICS

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

(2019) Samuel E. Jones et al.   Nature Communications

Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex

(2019) Xiaofeng Guo et al.   AGING CELL

Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

(2018) Shikshya Shrestha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study

(2018) Hirotaka Shoji et al.   Molecular Brain

R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multi-parent Populations

(2018) Karl W. Broman et al.   GENETICS

Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

GWAS identifies 14 loci for device-measured physical activity and sleep duration

(2018) Aiden Doherty et al.   Nature Communications

Pleiotropic genetic effects influencing sleep and neurological disorders

(2017) Olivia J Veatch et al.   LANCET NEUROLOGY

Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep

(2017) Huiyan Huang et al.   G3-Genes Genomes Genetics

The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans

(2017) Michael J Iannacone et al.   eLife

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

(2017) S H Witt et al.   Translational Psychiatry

Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases

(2017) Marta Fumagalli et al.   Frontiers in Pharmacology

A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Regulation of Sleep in Drosophila

(2017) Mark N. Wu et al.   SLEEP

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity – Ready for clinical practice?

(2016) Didier Meulendijks et al.   CANCER TREATMENT REVIEWS

Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells

(2016) Rune Nørgaard Rasmussen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Upfront Genotyping ofDPYD*2Ato Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

(2016) Maarten J. Deenen et al.   JOURNAL OF CLINICAL ONCOLOGY

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Forward-genetics analysis of sleep in randomly mutagenized mice

(2016) Hiromasa Funato et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

(2016) Jacqueline M Lane et al.   NATURE GENETICS

A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States

(2016) Cindy N. Chiu et al.   NEURON

Reduced Prepulse Inhibition as a Biomarker of Schizophrenia

(2016) Auxiliadora Mena et al.   Frontiers in Behavioral Neuroscience

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

(2016) Samuel E. Jones et al.   PLoS Genetics

High-throughput, motility-based sorter for microswimmers such as C. elegans

(2015) Jinzhou Yuan et al.   LAB ON A CHIP

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Mouse Universal Genotyping Array: From Substrains to Subspecies

(2015) Andrew P. Morgan et al.   G3-Genes Genomes Genetics

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(2015) Lisa E. Gralinski et al.   PLoS Genetics

A Rare Functional Noncoding Variant at the GWAS-Implicated MIR137 / MIR2682 Locus Might Confer Risk to Schizophrenia and Bipolar Disorder

(2014) Jubao Duan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene

(2014) Jill M. Recla et al.   MAMMALIAN GENOME

Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells

(2014) Matthew J. Hill et al.   SCHIZOPHRENIA RESEARCH

A Novel BHLHE41 Variant is Associated with Short Sleep and Resistance to Sleep Deprivation in Humans

(2014) Renata Pellegrino et al.   SLEEP

Quantitative Trait Locus Mapping Methods for Diversity Outbred Mice

(2014) D. M. Gatti et al.   G3-Genes Genomes Genetics

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

The Database of Genomic Variants: a curated collection of structural variation in the human genome

(2013) Jeffrey R. MacDonald et al.   NUCLEIC ACIDS RESEARCH

High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population

(2012) Karen L. Svenson et al.   GENETICS

The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population

(2012)   GENETICS

Identification and Characterization of a Sleep-Active Cell Group in the Rostral Medullary Brainstem

(2012) C. Anaclet et al.   JOURNAL OF NEUROSCIENCE

The diversity outbred mouse population

(2012) Gary A. Churchill et al.   MAMMALIAN GENOME

The mammalian gene function resource: the international knockout mouse consortium

(2012) Allan Bradley et al.   MAMMALIAN GENOME

Role of Homer Proteins in the Maintenance of Sleep-Wake States

(2012) Nirinjini Naidoo et al.   PLoS One

Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability

(2011) M. H. Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

(2010) André B.P. van Kuilenburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hemizygous deletions on chromosome 1p21.3 involving the DPYD gene in individuals with autism spectrum disorder

(2010) MT Carter et al.   CLINICAL GENETICS

β-Alanine as a small molecule neurotransmitter

(2010) K.E. Tiedje et al.   NEUROCHEMISTRY INTERNATIONAL

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

(2009) Y. He et al.   SCIENCE

Heritability of Sleep Electroencephalogram

(2008) Urte Ambrosius et al.   BIOLOGICAL PSYCHIATRY

GABA and glycine as neurotransmitters: a brief history

(2006) N G Bowery et al.   BRITISH JOURNAL OF PHARMACOLOGY