Article
Chemistry, Multidisciplinary
Xiaopan Song, Ting Zhang, Lei Wu, Ruijin Hu, Wentao Qian, Zongguang Liu, Junzhuan Wang, Yi Shi, Jun Xu, Kunji Chen, Linwei Yu
Summary: This research demonstrates a fabrication method for large-area stretchable electronics using silicon nanowire field effect transistors (SiNW-FETs). By utilizing the solid-liquid-solid mechanism, SiNW channels can be precisely grown onto elastomers and transferred onto large-area substrates. The SiNW-FETs exhibit high performance and stability, making them promising for future flexible display and wearable electronic applications.
Article
Chemistry, Multidisciplinary
Yan Zhu, Qianhui Wei, Qingxi Jin, Gangrong Li, Qingzhu Zhang, Han Xiao, Tengfei Li, Feng Wei, Yingchun Luo
Summary: In this paper, a simple mixed-catalyzer layer modified silicon nanowire field-effect transistor biosensor was proposed, which enabled direct detection of glucose with low-charge in high ionic strength solutions. The biosensor showed high sensitivity, strong specificity, and fast real-time response.
Article
Electrochemistry
Chi-Chang Wu
Summary: In response to the COVID-19 pandemic, a polycrystalline silicon nanowire field-effect transistor (NWFET) was developed to detect the spike protein of SARS-CoV-2. The biosensor demonstrated high sensitivity and stability, making it a promising tool for rapid screening of the virus.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Review
Chemistry, Analytical
Ruisha Hao, Lei Liu, Jiangyan Yuan, Lingli Wu, Shengbin Lei
Summary: In comparison with traditional clinical diagnosis methods, field-effect transistor (FET)-based biosensors have the advantages of fast response, easy miniaturization and integration for high-throughput screening, which demonstrates their great technical potential in the biomarker detection platform. This mini review mainly summarizes recent advances in FET biosensors, including design strategies for sensitive assay, immunoassay based on a single biosensor, integration into large-area arrays for high-throughput testing, integration into microfluidics for lab-on-chip sensing platforms, and the prospects for commercialization of FET sensing systems.
Article
Chemistry, Analytical
Abhiroop Bhattacharjee, Thanh Chien Nguyen, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu
Summary: Using silicon nanowire field-effect transistors (SiNW-FETs) for impedance sensing shows potential for label-free detection of biomolecules by overcoming the Debye-screening limitation. Employing an electronic circuit model in SPICE, we quantitatively evaluated the influence of various device parameters on the transfer function of the SiNW-FETs and investigated how biomolecule binding affects impedance spectra. Mathematical analysis and simulation results led to proposed methods for improving the impedimetric readout of SiNW-FET biosensors.
Article
Chemistry, Analytical
Jiasheng Yan, Chuang Wang, Yusheng Fu, Jiuchuan Guo, Jinhong Guo
Summary: This article introduces a disposable Coulter counting analysis kit based on 3D microfluidic printing technology, which improves the accuracy of Coulter cell count analysis and solves the problem of clogging. The kit is convenient, hygienic, and can be widely used in POCT detection scenarios.
Article
Biophysics
Cao-An Vu, Hsin-Ying Lai, Chia-Yu Chang, Hardy Wai-Hong Chan, Wen-Yih Chen
Summary: MicroRNA sensing is crucial for diagnosing diseases, especially cancers, and a novel technique using modified silicon nanowire field-effect transistors (SiNWFETs) with two-component mixed self-assembled monolayers (mSAMs) has been developed for miRNA-21 detection, showing high sensitivity and selectivity. The approach has the potential to revolutionize nucleic acid testing for disease diagnosis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Francisco M. Espinosa, Manuel R. Uhlig, Ricardo Garcia
Summary: Silicon nanowire (SiNW) field-effect transistors (FETs) have been developed as highly sensitive label-free biomolecular sensors. This study combines nanolithography, chemical functionalization, electrical measurements, and molecular recognition methods to correlate the current measured by the SiNW transistor with specific molecular recognition events on its surface.
Article
Materials Science, Multidisciplinary
A. Lale, A. Grappin, A. Lecestre, L. Mazenq, J. Launay, Pierre Temple-Boyer
Summary: A technological process was developed to integrate silicon-nanowire-based field-effect nanodevices on a silicon-on-insulator (SOI) substrate. The fabrication of SiNW-FET and SiNW-ISFET devices was achieved through a double reactive ion etching process and a gate process involving SiO2 thermal oxidation growth and Al2O3 atomic layer deposition. The devices exhibited excellent electrical characteristics and demonstrated sensitivity in pH analysis at the submicronic scale.
Article
Biophysics
Dujuan Li, Huiyi Chen, Kai Fan, Vladimir Labunov, Serguei Lazarouk, Xiaojie Yue, Chaoran Liu, Xun Yang, Linxi Dong, Gaofeng Wang
Summary: The FET biosensor based on uniform high-response silicon nanowire array studied in this research shows significant superiority in real-time, label-free, super-sensitive detection of PIK3CA E542K ctDNA, achieving ultralow detection limit of 10 aM and high selectivity in recognizing complementary target ctDNA. The biosensor also demonstrated potential for clinical applications by successfully detecting target ctDNA in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Seong-Kun Cho, Won-Ju Cho
Summary: The study developed a highly sensitive and selective sodium ion sensor using a dual-gate structured silicon nanowire field-effect transistor and a sodium-selective membrane extended gate. The sensor showed high sensitivity to sodium ions and excellent selectivity, with low sensitivities to other ions and demonstrated reliability and stability under non-ideal behaviors.
Article
Chemistry, Analytical
Diwakar M. Awate, Cicero C. Pola, Erica Shumaker, Carmen L. Gomes, Jaime J. Juarez
Summary: Despite the limitations of flow cytometers, a 3D-printed imaging platform (3DPIP) has been developed to accurately count particles and conduct fluorescence microscopy efficiently. The 3DPIP utilizes a custom particle counter code and machine vision-based algorithm to identify and count particles, showing comparable accuracy to commercial particle counters. Additionally, the platform can perform static experiments and flow-through experiments effectively, making it a promising tool for use in resource-limited clinical environments.
Article
Chemistry, Analytical
Suh Kuan Yong, Shang-Kai Shen, Chia-Wei Chiang, Ying-Ya Weng, Ming-Pei Lu, Yuh-Shyong Yang
Summary: In this study, silicon nanowire field-effect transistors (pSiNWFETs) were fabricated through commercial process technology and chemically functionalized for sensing hepatitis B virus surface antigen (HBsAg) and hepatitis B virus X protein (HBx) at the femto-molar level. The proteins' opposite net charges could suggest a complementary charge-based sensing mechanism in the pSiNWFET. The consistent correspondence between the threshold voltage shifts of pSiNWFETs and the polarity of the charges on the proteins studied indicates the potential for developing an accessible tool for biomedical applications.
Article
Chemistry, Analytical
Eunwoo Baek, Jaemin Son, Kyoungah Cho, Sangsig Kim
Summary: In this paper, a logic-in-memory (LIM) inverter using a silicon nanowire (SiNW) structure is proposed. Simulation results show that the inverter has high voltage gain and zero static power consumption.
Article
Chemistry, Analytical
Alex C. Tseng, Kensuke Ito, David Lynall, Igor G. Savelyev, Marina Blumin, Shiliang Wang, Harry E. Ruda, Toshiya Sakata
Summary: The trapping of environmental charges in surface states can dominate electrical transport in nanostructured field-effect transistors used as sensors, leading to exceptional sensitivity. However, the time dependencies on experimental timescales can result in hysteresis of FET conductance and signal instability. While hysteresis is usually suppressed by chemical surface treatments, it can also be studied as a source of information for ion sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Yi Lu, Die Jia, Xianbin Ma, Mengyun Liang, Shengxin Hou, Wei Qiu, Yuan Gao, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: A stimuli-responsive prodrug nanogel was developed using a two-in-one cross-linking strategy to deliver a combination of chemotherapeutic drugs for improving the deficiencies of chemotherapy and enhancing cancer therapeutic efficiency. The high drug loading capacity and suitable nanoscale size of the obtained nanogel facilitate cell uptake and tumor penetration, leading to enhanced tumor growth inhibition by the synergistic DNA damage in response to the reductive tumor microenvironment. This unique prodrug nanogel shows promise as a candidate for effective tumor treatment-based chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yong-E Gao, Shengxin Hou, Jiaqi Cheng, Xinyi Li, Yongqiong Wu, Yuran Tang, Yanke Li, Peng Xue, Yuejun Kang, Zhigang Xu, Mingming Guo
Summary: Nanotheranostic systems are expected to enhance the efficacy of photodynamic therapy (PDT) by overcoming the limitations of conventional PDT. In this study, silk sericin-based nanoparticles (SSC NPs) were designed and shown to have improved intracellular uptake efficiency and anticancer effects compared to free Ce6.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Mengyun Liang, Yuan Gao, Wei Qiu, Mengjie Ye, Junfeng Hu, Jiming Xu, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: This study introduces an acid-sensitive supramolecular nanoassembly, which enhances therapeutic efficacy by conquering physiological blockages and achieves deep intratumor infiltration in the tumor microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Shiyan Fu, Ruihao Yang, Junjie Ren, Jiahui Liu, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities are synthesized as bioreactors responsive to TME cues for augmented sonodynamic therapy (SDT) and chemodynamic therapy (CDT), eliciting a strong immune response.
Article
Chemistry, Multidisciplinary
Yinmin Zhao, Jiahui Liu, Mengting He, Qi Dong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The construction of a smart therapeutic nanoplatform consisting of TiO2@Pt/GOx (TPG) allows for efficient sonodynamic therapy (SDT) and starvation therapy (ST), which lead to systemic tumor suppression and hypoxia alleviation in the tumor microenvironment. The optimized energy structure of TPG enables rapid generation of singlet oxygen and hydroxyl radicals. The accumulation of reactive oxygen species and glucose depletion facilitated by TPG result in oxidative damage and energy exhaustion of cancer cells, amplified by Pt-catalyzed oxygen self-supply. The combinatorial therapy also triggers immunogenetic cell death and subsequent suppression of distant tumors and metastasis through antitumor immunity.
Review
Chemistry, Multidisciplinary
Xianbin Ma, Shu-Jin Li, Yuantong Liu, Tian Zhang, Peng Xue, Yuejun Kang, Zhi-Jun Sun, Zhigang Xu
Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Materials Science, Biomaterials
Lei Zhang, Ruihao Yang, Honglian Yu, Zhigang Xu, Yuejun Kang, Hongjuan Cui, Peng Xue
Summary: This study successfully developed a multifunctional SF-derived nanoplatform combining photodynamic therapy and photothermal therapy, which can effectively inhibit tumor growth and provide useful insights for more medical applications in the future.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Ya Gao, Wei Zhang, Yan Fang Cheng, Yang Cao, Zhigang Xu, Li Qun Xu, Yuejun Kang, Peng Xue
Summary: A PEGDA microneedle patch with surface coating of nanosilver encapsulated gelatin/sucrose film was developed for antibacterial applications, enhancing skin permeation and efficient drug delivery. The rapid release of nanosilver from the microneedles under physiological conditions demonstrated good potential for a broad-spectrum antibacterial effect. Furthermore, the film-coated microneedles exhibited good mechanical strength for skin penetration and showed antibacterial activity against both Gram-positive and Gram-negative bacteria in vitro.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Analytical
Xue Zhao, Yusheng Fu, Chunhui Ren, Jinhong Guo, Yuejun Kang
Summary: An up-conversion luminescent system for the quantitative detection of morphine was developed in this study, utilizing infrared light as an excitation source and up-conversion luminescent material as a label. The system achieved high sensitivity by processing image data with an algorithm and calculating the T/C value, with a detection limit of 0.1 ng mg(-1) and a detection time within 0.5 min.
Article
Materials Science, Biomaterials
Ruihao Yang, Ruidong Li, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Qian Li, Junjie Ren, Qiubing Chen, Weiwei Liu, Zhigang Xu, Yang Cao, Yuejun Kang, Peng Xue
Article
Materials Science, Biomaterials
Tian Zhang, Xianbin Ma, Shuang Bai, Yajun Wang, Xiaoli Zhang, Yi Lu, Feiqiu Wen, Peng Xue, Yuejun Kang, Zhigang Xu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Xiaodan Jiao, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Article
Materials Science, Biomaterials
Tian Zhang, Yajun Wang, Xianbin Ma, Cuilan Hou, Shuangyu Lv, Die Jia, Yi Lu, Peng Xue, Yuejun Kang, Zhigang Xu
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Mengmeng Hou, Weiwei Liu, Lei Zhang, Leiyang Zhang, Zhigang Xu, Yang Cao, Yuejun Kang, Peng Xue
BIOMATERIALS SCIENCE
(2020)