Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease

Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals

(2021) Le-Yun Sun et al.   BIOORGANIC CHEMISTRY

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

(2021) Kangsa Amporndanai et al.   Nature Communications

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

(2020) Helmut Sies et al.   FREE RADICAL BIOLOGY AND MEDICINE

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Jonathan Kil et al.   LANCET

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections

(2015) Shankar Thangamani et al.   Scientific Reports

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

(2014) Gajendra Kumar Azad et al.   MOLECULAR BIOLOGY REPORTS

The early research and development of ebselen

(2013) Michael J. Parnham et al.   BIOCHEMICAL PHARMACOLOGY

An efficient copper mediated synthetic methodology for benzo[d]isothiazol-3(2H)-ones and related sulfur–nitrogen heterocycles

(2012) Bhagat Singh Bhakuni et al.   TETRAHEDRON LETTERS