Influence of Linkers within Stimuli-Responsive Prodrugs on Cancer Therapy: A Case of Five Doxorubicin Dimer-Based Nanoparticles

Bioorthogonal catalytic patch

(2021) Zhaowei Chen et al.   Nature Nanotechnology

The evolution of commercial drug delivery technologies

(2021) Ava M. Vargason et al.   Nature Biomedical Engineering

Recent trends in bioresponsive linker technologies of Prodrug-Based Self-Assembling nanomaterials

(2021) Anne Nguyen et al.   BIOMATERIALS

Regulating the Anticancer Efficacy of Sgc8–Combretastatin A4 Conjugates: A Case of Recognizing the Significance of Linker Chemistry for the Design of Aptamer-Based Targeted Drug Delivery Strategies

(2021) Zhiyong Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors

(2021) Xin Liu et al.   Advanced Science

Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy

(2020) Shiqian Gao et al.   ADVANCED MATERIALS

Fluorogenic Probe Using a Mislow–Evans Rearrangement for Real‐Time Imaging of Hydrogen Peroxide

(2020) Dianne Pham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Paclitaxel Prodrug Activatable by Irradiation in a Hypoxic Microenvironment

(2020) Shiyu Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery

(2020) Huanli Sun et al.   ACS Macro Letters

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors

(2020) Ran Chen et al.   Cancers

Antibody–Drug Conjugates: The Last Decade

(2020) Nicolas Joubert et al.   Pharmaceuticals

Comparison of Redox Responsiveness and Antitumor Capability of Paclitaxel Dimeric Nanoparticles with Different Linkers

(2020) Jian Wang et al.   CHEMISTRY OF MATERIALS

Quantitative self-assembly of photoactivatable small molecular prodrug cocktails for safe and potent cancer chemo-photodynamic therapy

(2020) Lingling Huang et al.   Nano Today

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

A Simple Glutathione-Responsive Turn-On Theranostic Nanoparticle for Dual-Modal Imaging and Chemo-Photothermal Combination Therapy

(2019) Yihui Li et al.   NANO LETTERS

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

(2019) Bingjun Sun et al.   Nature Communications

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics

(2018) Min Hee Lee et al.   CHEMICAL SOCIETY REVIEWS

The effect of linkers on the self-assembling and anti-tumor efficacy of disulfide-linked doxorubicin drug-drug conjugate nanoparticles

(2018) Yaoqi Wang et al.   JOURNAL OF CONTROLLED RELEASE

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas

(2018) Jun Gong et al.   Drug Design Development and Therapy

ROS-responsive drug delivery systems for biomedical applications

(2018) Wenhui Tao et al.   Asian Journal of Pharmaceutical Sciences

Active Targeting of Drugs and Bioactive Molecules via Oral Administration by Ligand-Conjugated Lipidic Nanocarriers: Recent Advances

(2018) A. B. Shreya et al.   AAPS PHARMSCITECH

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment

(2018) Chunlin Zhuang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Leveraging Physiology for Precision Drug Delivery

(2017) Wujin Sun et al.   PHYSIOLOGICAL REVIEWS

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

(2017) Suping Li et al.   Nature Biomedical Engineering

Evolution of macromolecular complexity in drug delivery systems

(2017) Ashok Kakkar et al.   Nature Reviews Chemistry

Redox-Sensitive Hydroxyethyl Starch–Doxorubicin Conjugate for Tumor Targeted Drug Delivery

(2016) Hang Hu et al.   ACS Applied Materials & Interfaces

Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics

(2016) Keitaro Umezawa et al.   Nature Chemistry

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Bridging the gap between qualitative and quantitative colocalization results in fluorescence microscopy studies

(2013) Vadim Zinchuk et al.   Scientific Reports

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

(2008) Ahn Na Koo et al.   CHEMICAL COMMUNICATIONS

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS