A Paclitaxel Prodrug Activatable by Irradiation in a Hypoxic Microenvironment

A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment

(2020) Jianhua Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of Upconverted Metal–Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors

(2020) Yulei Shao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Hypoxia‐Responsive Molecular Container for Tumor‐Targeted Therapy

(2020) Tian‐Xing Zhang et al.   ADVANCED MATERIALS

GSH and H 2 O 2 Co‐Activatable Mitochondria‐Targeted Photodynamic Therapy under Normoxia and Hypoxia

(2020) Jian Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Perfluorocarbon-Loaded and Redox-Activatable Photosensitizing Agent with Oxygen Supply for Enhancement of Fluorescence/Photoacoustic Imaging Guided Tumor Photodynamic Therapy

(2019) DanRong Hu et al.   ADVANCED FUNCTIONAL MATERIALS

A Semiconducting Polymer Nano-prodrug for Hypoxia-Activated Photodynamic Cancer Therapy

(2019) Dong Cui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors

(2019) Shengcai Yang et al.   ADVANCED MATERIALS

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

(2019) Conghui Liu et al.   ACS Nano

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

(2019) Dongdong Wang et al.   ADVANCED MATERIALS

A Hypoxia‐Responsive Albumin‐Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

(2019) Guangbao Yang et al.   ADVANCED MATERIALS

Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity

(2019) Fang Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self‐Supply of O 2 and H 2 O 2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

(2019) Shutao Gao et al.   Advanced Science

Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

(2019) Abhishek Sahu et al.   BIOMATERIALS

Hypoxia-Triggered Nanoscale Metal–Organic Frameworks for Enhanced Anticancer Activity

(2018) Ming Liu et al.   ACS Applied Materials & Interfaces

Light-Induced Hypoxia-Triggered Living Nanocarriers for Synergistic Cancer Therapy

(2018) Wenliang Wang et al.   ACS Applied Materials & Interfaces

Light-Activatable Red Blood Cell Membrane-Camouflaged Dimeric Prodrug Nanoparticles for Synergistic Photodynamic/Chemotherapy

(2018) Qing Pei et al.   ACS Nano

Nanoparticles of Chlorin Dimer with Enhanced Absorbance for Photoacoustic Imaging and Phototherapy

(2018) Xiaohua Zheng et al.   ADVANCED FUNCTIONAL MATERIALS

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

(2018) Xingshu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma

(2017) Qing Pei et al.   JOURNAL OF CONTROLLED RELEASE

Dual-Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self-Sufficient Nanoplatform

(2017) Li-Han Liu et al.   Small

Manganese Dioxide Coated WS2 @Fe3 O4 /sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy

(2017) Guangbao Yang et al.   Small

Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy

(2016) Liangzhu Feng et al.   ACS Nano

MnO2Gatekeeper: An Intelligent and O2-Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2-Sensitive MRI

(2016) Zhifang Ma et al.   ADVANCED FUNCTIONAL MATERIALS

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

(2016) Chenggen Qian et al.   ADVANCED MATERIALS

Protein-Framed Multi-Porphyrin Micelles for a Hybrid Natural-Artificial Light-Harvesting Nanosystem

(2016) Yannan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy

(2016) Kai Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hypoxia-Sensitive Materials for Biomedical Applications

(2016) Jicheng Yu et al.   ANNALS OF BIOMEDICAL ENGINEERING

Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

(2016) Akhil Patel et al.   BIOTECHNOLOGY ADVANCES

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

(2016) Chieh-Cheng Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors

(2015) Yanyan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

(2015) Huachao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

(2015) Yuhao Cheng et al.   Nature Communications

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

(2014) Edward A. Sykes et al.   ACS Nano

Ablation of Hypoxic Tumors with Dose-Equivalent Photothermal, but Not Photodynamic, Therapy Using a Nanostructured Porphyrin Assembly

(2013) Cheng S. Jin et al.   ACS Nano

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

(2012) Li Tang et al.   ACS Nano

pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride

(2012) Yinfeng Du et al.   BIOMATERIALS

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

(2012) Wenchuan She et al.   BIOMATERIALS

Activatable Photosensitizers for Imaging and Therapy

(2010) Jonathan F. Lovell et al.   CHEMICAL REVIEWS

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

(2010) William A Denny   Future Oncology

Paclitaxel chemotherapy for the treatment of gastric cancer

(2009) Junichi Sakamoto et al.   Gastric Cancer

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology