Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates
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Title
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates
Authors
Keywords
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Journal
Cellular & Molecular Immunology
Volume 19, Issue 2, Pages 222-233
Publisher
Springer Science and Business Media LLC
Online
2022-01-05
DOI
10.1038/s41423-021-00809-2
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Note: Only part of the references are listed.- Adaptive immunity to SARS-CoV-2 and COVID-19
- (2021) Alessandro Sette et al. CELL
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- (2021) Alexandra Tauzin et al. Cell Host & Microbe
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- (2020) Markus Hoffmann et al. MOLECULAR CELL
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- (2020) Vincent J. Munster et al. NATURE
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- (2020) Sharon E Fox et al. Lancet Respiratory Medicine
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- (2020) Luca Carsana et al. LANCET INFECTIOUS DISEASES
- Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
- (2020) Noe B. Mercado et al. NATURE
- Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
- (2020) Carolyn Rydyznski Moderbacher et al. CELL
- SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
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- Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
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- Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome
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- Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques
- (2020) Robert V. Blair et al. AMERICAN JOURNAL OF PATHOLOGY
- Safety of AS03-adjuvanted influenza vaccines: A review of the evidence
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- Correlates of adjuvanticity: A review on adjuvants in licensed vaccines
- (2018) Giuseppe Del Giudice et al. SEMINARS IN IMMUNOLOGY
- AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization
- (2018) Surender Khurana et al. npj Vaccines
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- (2017) Wivine Burny et al. Frontiers in Immunology
- Impact of adjuvants on CD4 + T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial
- (2016) Geert Leroux-Roels et al. CLINICAL IMMUNOLOGY
- Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
- (2016) Jincun Zhao et al. IMMUNITY
- Structure, Function, and Evolution of Coronavirus Spike Proteins
- (2016) Fang Li Annual Review of Virology
- T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
- (2015) Jinfang Zhu CYTOKINE
- Cytokine Diversity in the Th1-Dominated Human Anti-Influenza Response Caused by Variable Cytokine Expression by Th1 Cells, and a Minor Population of Uncommitted IL-2+IFNγ- Thpp Cells
- (2014) Nan Deng et al. PLoS One
- Recent progress concerning CpG DNA and its use as a vaccine adjuvant
- (2013) Hidekazu Shirota et al. Expert Review of Vaccines
- Increase in IFNγ−IL-2+ Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza
- (2013) Jason M. Weaver et al. PLoS One
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- (2013) William L. Heyward et al. VACCINE
- Revealing the role of CD4+T cells in viral immunity: Figure 1.
- (2012) Andrea J. Sant et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults
- (2012) Scott A. Halperin et al. VACCINE
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- (2010) Philippe Moris et al. JOURNAL OF CLINICAL IMMUNOLOGY
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- The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza
- (2010) Marc-André D’Aoust et al. PLANT BIOTECHNOLOGY JOURNAL
- Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection
- (2009) J. Chen et al. JOURNAL OF VIROLOGY
- The spike protein of SARS-CoV — a target for vaccine and therapeutic development
- (2009) Lanying Du et al. NATURE REVIEWS MICROBIOLOGY
- Phenotype and function of human T lymphocyte subsets: Consensus and issues
- (2008) Victor Appay et al. CYTOMETRY PART A
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