Human embryonic genome activation initiates at the one-cell stage

Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm

(2021) Yu H. Sun et al.   Nature Communications

Naive stem cell blastocyst model captures human embryo lineage segregation

(2021) Ayaka Yanagida et al.   Cell Stem Cell

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

(2021) Xiaodong Liu et al.   NATURE

Blastocyst-like structures generated from human pluripotent stem cells

(2021) Leqian Yu et al.   NATURE

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3

(2021) Laura Santini et al.   Nature Communications

Target gene-independent functions of MYC oncoproteins

(2020) Apoorva Baluapuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility

(2020) Wei Zheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation

(2020) Maria Samata et al.   CELL

Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

(2020) Qian-Qian Sha et al.   Nature Communications

Risk of cancer in infertile women: analysis of US claims data

(2019) Gayathree Murugappan et al.   HUMAN REPRODUCTION

Caput Epididymidal Mouse Sperm Support Full Development

(2019) Dongjie Zhou et al.   DEVELOPMENTAL CELL

Evaluating stably expressed genes in single cells

(2019) Yingxin Lin et al.   GigaScience

Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

(2019) Lizhi Leng et al.   Cell Stem Cell

Advances in genome editing through control of DNA repair pathways

(2019) Charles D. Yeh et al.   NATURE CELL BIOLOGY

Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility

(2018) Qing Sang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution

(2018) Lei Gao et al.   CELL

Nuclear genes involved in mitochondrial diseases caused by instability of mitochondrial DNA

(2018) Joanna Rusecka et al.   JOURNAL OF APPLIED GENETICS

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Chromatin analysis in human early development reveals epigenetic transition during ZGA

(2018) Jingyi Wu et al.   NATURE

Generation of human oogonia from induced pluripotent stem cells in vitro

(2018) Chika Yamashiro et al.   SCIENCE

Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure

(2018) Lun Suo et al.   Scientific Reports

DUX-family transcription factors regulate zygotic genome activation in placental mammals

(2017) Alberto De Iaco et al.   NATURE GENETICS

Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

(2017) Peter G Hendrickson et al.   NATURE GENETICS

Polycomb Responds to Low Levels of Transcription

(2017) Georgina Berrozpe et al.   Cell Reports

Highly efficient and precise base editing in discarded human tripronuclear embryos

(2017) Guanglei Li et al.   Protein & Cell

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

(2016) Xiangjin Kang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Reprogramming the genome to totipotency in mouse embryos

(2015) Li-quan Zhou et al.   TRENDS IN CELL BIOLOGY

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

(2013) Zhigang Xue et al.   NATURE

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm

(2013) Bin Wang et al.   PLoS One

Combining Different mRNA Capture Methods to Analyze the Transcriptome: Analysis of the Xenopus laevis Transcriptome

(2013) Michael D. Blower et al.   PLoS One

MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

(2013) Kaushal Joshi et al.   STEM CELLS

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Nerve Growth Factor-Induced Cell Cycle Reentry in Newborn Neurons Is Triggered by p38MAPK-Dependent E2F4 Phosphorylation

(2012) S. M. Morillo et al.   MOLECULAR AND CELLULAR BIOLOGY

Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development

(2011) R. Vassena et al.   DEVELOPMENT

Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres

(2011) Matthew D VerMilyea et al.   EMBO JOURNAL

The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting

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The Transcriptome of a Human Polar Body Accurately Reflects Its Sibling Oocyte

(2011) Adrian Reich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Detection and quantification of mRNA in single human polar bodies: a minimally invasive test of gene expression during oogenesis

(2010) Peter C. Klatsky et al.   MOLECULAR HUMAN REPRODUCTION

Analysis and design of RNA sequencing experiments for identifying isoform regulation

(2010) Yarden Katz et al.   NATURE METHODS

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

(2009) J. M. Facucho-Oliveira et al.   Stem Cell Reviews and Reports

Second meiotic arrest and exit in frogs and mice

(2008) Anthony C.F. Perry et al.   EMBO REPORTS

ART failure: oocyte contributions to unsuccessful fertilization

(2008) J. E. Swain et al.   HUMAN REPRODUCTION UPDATE

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE