In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

Genetic and Cellular Contributions to Liver Regeneration

(2021) Roger Liang et al.   Cold Spring Harbor Perspectives in Biology

Two conserved epigenetic regulators prevent healthy ageing

(2020) Jie Yuan et al.   NATURE

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Gene regulatory programmes of tissue regeneration

(2020) Joseph A. Goldman et al.   NATURE REVIEWS GENETICS

BAZ 2A safeguards genome architecture of ground‐state pluripotent stem cells

(2020) Damian Dalcher et al.   EMBO JOURNAL

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice

(2019) Yuhua Tian et al.   GASTROENTEROLOGY

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

(2019) Lara Planas-Paz et al.   Cell Stem Cell

Epigenetic Compensation Promotes Liver Regeneration

(2019) Shuang Wang et al.   DEVELOPMENTAL CELL

High-content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice

(2019) Adam M. Zahm et al.   GASTROENTEROLOGY

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

(2019) Luigi Aloia et al.   NATURE CELL BIOLOGY

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

(2018) Rajiv K. Khajuria et al.   CELL

Vitamin D Switches BAF Complexes to Protect β Cells

(2018) Zong Wei et al.   CELL

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

(2018) Shuyuan Zhang et al.   DEVELOPMENTAL CELL

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration

(2018) Shuyuan Zhang et al.   GASTROENTEROLOGY

Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform

(2018) Kirk J. Wangensteen et al.   HEPATOLOGY

TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury

(2018) Amber W. Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The balancing act of the liver: tissue regeneration versus fibrosis

(2018) Lucía Cordero-Espinoza et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

(2018) Matthew C Canver et al.   Nature Protocols

Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism

(2018) Yasuharu Nagahama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

(2016) Xuxu Sun et al.   Cell Stem Cell

Modulation of tissue repair by regeneration enhancer elements

(2016) Junsu Kang et al.   NATURE

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Liver regeneration — mechanisms and models to clinical application

(2016) Stuart J. Forbes et al.   Nature Reviews Gastroenterology & Hepatology

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

(2015) Peiling Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

(2015) Ludovic Drouin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

lncRNA Maturation to Initiate Heterochromatin Formation in the Nucleolus Is Required for Exit from Pluripotency in ESCs

(2014) Nataša Savić et al.   Cell Stem Cell

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

(2014) Lei Gu et al.   NATURE GENETICS

A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration

(2013) Torsten Wuestefeld et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Large-scale organization of ribosomal DNA chromatin is regulated by Tip5

(2013) Karina Zillner et al.   NUCLEIC ACIDS RESEARCH

The UCSC genome browser and associated tools

(2012) R. M. Kuhn et al.   BRIEFINGS IN BIOINFORMATICS

Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice

(2012) Gui Jie Feng et al.   GASTROENTEROLOGY

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

(2010) P Gaub et al.   CELL DEATH AND DIFFERENTIATION

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

(2009) Yonggang Zhou et al.   NATURE CELL BIOLOGY

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Epigenetic Engineering of Ribosomal RNA Genes Enhances Protein Production

(2009) Raffaella Santoro et al.   PLoS One

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

(2008) Claudia Mitchell et al.   Nature Protocols

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY