LRRC8A is essential for volume‐regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension

SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway

(2021) Bao-Yi Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology

(2020) Toshiki Yamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation

(2019) Canzhao Liu et al.   CIRCULATION

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

(2019) Can-zhao Liu et al.   ACTA PHARMACOLOGICA SINICA

Smooth muscle-specific TMEM16A expression protects against angiotensin II-induced cerebrovascular remodeling via suppressing extracellular matrix deposition

(2019) Xue-Lin Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of a volume-regulated anion channel of the LRRC8 family

(2018) Dawid Deneka et al.   NATURE

Cryo-EM structures of the human volume-regulated anion channel LRRC8

(2018) Go Kasuya et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the human volume regulated anion channel

(2018) Jennifer M Kefauver et al.   eLife

TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase–Derived Reactive Oxygen Species Generation in HypertensionNovelty and Significance

(2017) Ming-Ming Ma et al.   HYPERTENSION

Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl − current and migration in cultured vascular smooth muscle cells

(2016) Ming-Ming Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells

(2016) Can-Zhao Liu et al.   CIRCULATION JOURNAL

Non-essential contribution of LRRC8A to volume regulation

(2016) Lalida Sirianant et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

(2015) Andrea Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells

(2013) Lei Jiang et al.   APOPTOSIS

Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension

(2013) Ling-Yun Zheng et al.   CARDIOVASCULAR RESEARCH

Cell volume regulation in epithelial physiology and cancer

(2013) Stine F. Pedersen et al.   Frontiers in Physiology

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

(2012) Mi Wang et al.   CIRCULATION

Vascular Remodeling in Hypertension

(2011) Ernesto L. Schiffrin   HYPERTENSION

Simvastatin Ameliorates Rat Cerebrovascular Remodeling During Hypertension via Inhibition of Volume-Regulated Chloride Channel

(2010) Yu-Jie Liu et al.   HYPERTENSION

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Silence of ClC-3 chloride channel inhibits cell proliferation and the cell cycle via G1/S phase arrest in rat basilar arterial smooth muscle cells

(2008) Y.-B. Tang et al.   CELL PROLIFERATION