STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3

(2021) Peng Tang et al.   CELL DEATH AND DIFFERENTIATION

STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion

(2021) Changfeng Li et al.   Frontiers in Cell and Developmental Biology

SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

(2021) Toshio Kanno et al.   Communications Biology

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

(2020) Melissa M. Walker et al.   Frontiers in Immunology

Structural cells are key regulators of organ-specific immune responses

(2020) Thomas Krausgruber et al.   NATURE

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

(2020) Line S. Reinert et al.   JOURNAL OF CLINICAL INVESTIGATION

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Omega-3 fatty acids as regulators of brown/beige adipose tissue: from mechanisms to therapeutic potential

(2019) Marta Fernández-Galilea et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy

(2019) Jun‐Jun Wu et al.   MEDICINAL RESEARCH REVIEWS

Adaptive thermogenesis by dietary n-3 polyunsaturated fatty acids: Emerging evidence and mechanisms

(2018) Rong Fan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

(2018) Rayane A. Ghandour et al.   JOURNAL OF LIPID RESEARCH

Omega-6 fatty acids and inflammation

(2018) Jacqueline K. Innes et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

(2017) Silvia Cerboni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

(2017) Maroof Hasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clock-dependent and system-driven oscillators interact in the suprachiasmatic nuclei to pace mammalian circadian rhythms

(2017) Karine Abitbol et al.   PLoS One

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

IRF3 promotes adipose inflammation and insulin resistance and represses browning

(2016) Manju Kumari et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of PUFAs in a Mouse Model of HSV-1 Chorioretinitis

(2016) Alejandro Berra et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

(2015) Hui Gyu Park et al.   FASEB JOURNAL

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

(2015) Philip J. Kranzusch et al.   MOLECULAR CELL

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

(2015) Thiago Belchior et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function

(2015) Jessica C. Ralston et al.   Obesity

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

STING-Associated Vasculopathy with Onset in Infancy — A New Interferonopathy

(2014) Yanick J. Crow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

STING/MPYS Mediates Host Defense against Listeria monocytogenes Infection by Regulating Ly6Chi Monocyte Migration

(2013) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Introducing Drugster: a comprehensive and fully integrated drug design, lead and structure optimization toolkit

(2012) D. Vlachakis et al.   BIOINFORMATICS

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Identification and characterization of a loss-of-function human MPYS variant

(2011) L Jin et al.   GENES AND IMMUNITY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Diet and Inflammation

(2010) Leo Galland   NUTRITION IN CLINICAL PRACTICE

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery

(2008) Santiago Vilar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE